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Where Are Insulin And Glucagon Synthesized

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How Is Glucagon An Antagonist Of Insulin?

Insulin and glucagon work together to balance your blood sugar levels, keeping them in the narrow range that your body requires. These hormones are like the yin and yang of blood glucose maintenance. Read on to learn more about how they function and what can happen when they dont work well. Insulin and glucagon work in whats called a negative feedback loop. During this process, one event triggers another, which triggers another, and so on, to keep your blood sugar levels balanced. During digestion, foods that contain carbohydrates are converted into glucose. Most of this glucose is sent into your bloodstream, causing a rise in blood glucose levels. This increase in blood glucose signals your pancreas to produce insulin. The insulin tells cells throughout your body to take in glucose from your bloodstream. As the glucose moves into your cells, your blood glucose levels go down. Some cells use the glucose as energy. Other cells, such as in your liver and muscles, store any excess glucose as a substance called glycogen. Your body uses glycogen for fuel between meals. About four to six hours after you eat, the glucose levels in your blood decrease, triggering your pancreas to produce g Continue reading >>

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Popular Questions

  1. aashkab

    Two very intertwining hormones that can be confusing at times, and I think the NBME likes to exploit it, so lets straighten this out because I've seen tons of inconsistencies from the sources I've used.
    Glucagon -
    1. promotes gluconeogenesis (via fructose 2, 6 bisphosphatase)
    2. promotes glycogenolysis (via phosphorylation of glycogen phosphorylase kinase)
    3. inhibits glycogen synthase
    4. promotes insulin secretion (IS THIS RIGHT? I saw it somewhere and wrote it down)
    Insulin -
    From FA -
    1. increases glucose transport
    2. increases glycogen synthesis/storage
    3. increases triglyceride synthesis/storage
    4. increases cellular uptake of K+
    5. increase protein synthesis
    6. increases sodium retention (don't really know how this happens)
    Not in FA -
    7. Inhibits Glucagon
    I'm really disappointed at the lack of glucagon emphasis in FA. It deserves its own half page at least. Anyways, if you guys can please see what is right /wrong and add your own idea of what the heck is going, it'd help out. I'm mainly very unsure of the INTERACTION between the two. I thought for a while they both inhibited each other, now it seems like only insulin inhibits.
    Thanks!

  2. vr123

    aashkab said: ↑
    Two very intertwining hormones that can be confusing at times, and I think the NBME likes to exploit it, so lets straighten this out because I've seen tons of inconsistencies from the sources I've used.
    Glucagon -
    1. promotes gluconeogenesis (via fructose 2, 6 bisphosphatase)
    2. promotes glycogenolysis (via phosphorylation of glycogen phosphorylase kinase)
    3. inhibits glycogen synthase
    4. promotes insulin secretion (IS THIS RIGHT? I saw it somewhere and wrote it down)
    Insulin -
    From FA -
    1. increases glucose transport
    2. increases glycogen synthesis/storage
    3. increases triglyceride synthesis/storage
    4. increases cellular uptake of K+
    5. increase protein synthesis
    6. increases sodium retention (don't really know how this happens)
    Not in FA -
    7. Inhibits Glucagon
    I'm really disappointed at the lack of glucagon emphasis in FA. It deserves its own half page at least. Anyways, if you guys can please see what is right /wrong and add your own idea of what the heck is going, it'd help out. I'm mainly very unsure of the INTERACTION between the two. I thought for a while they both inhibited each other, now it seems like only insulin inhibits.
    Thanks!
    Click to expand... Yes, glucagon stimulates a little insulin release because insulin-dependent tissues need it to take up glucose. If glucagon makes a whole lot of glucose via glycogenolysis, gluconeogeneis, etc but there isn't any insulin around, then the glucose won't be able to get into the cells. So that's why this seemingly contradictory effect occurs.

  3. XRanger

    yea i believed glucagon promotes insulin release to prevent wide fluctuation or glucose level getting too high.
    insulin also promotes acetyl-coa carboxylase which leads to increased malonyl coa

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