Xultophy® Reported A Better Option Than Basal-Bolus Insulin Therapy To Manage Type 2 Diabetes By Participants In The DUAL VII Clinical Trial

Xultophy® Reported a Better Option than Basal-Bolus Insulin Therapy to Manage Type 2 Diabetes by Participants in the DUAL VII Clinical Trial

Abu Dhabi, Uae (ots/PRNewswire) - Once-daily Xultophy® (insulin degludec/liraglutide) was a better option to manage diabetes compared to multiple daily injections of insulin (basal-bolus regimen). This was reported by people with type 2 diabetes whose blood sugar was not controlled on insulin glargine U100 with metformin, and who completed quality-of-life questionnaires as part of the DUAL VII clinical trial.[1] In addition, more people preferred to stay on Xultophy® compared with basal-bolus therapy (84.5% versus 68.1%).[1] These results were presented today at the 2017 International Diabetes Federation Congress in Abu Dhabi, UAE.
"Adding insulin injections at mealtime is an effective option to achieve desired blood glucose levels when basal insulin is not enough, but this raises the level of complexity in the patients' daily management of their diabetes. It can also lead to an increased risk of hypoglycaemia (low blood sugar) or weight gain", said Professor Esteban Jódar, University Hospital Quirón Salud, Madrid, Spain. "In the main analysis of the DUAL VII trial, Xultophy® delivered similar glucose reductions to a basal-bolus regimen alongside weight loss, as opposed to weight gain, and fewer episodes of hypoglycaemia. We now see that it also reduces treatment burden."
In the patient-reported outcomes (PRO) analysis from the DUAL VII clinical trial, 506 adults living with type 2 diabetes assessed their physical health, mental health and a number of diabetes-specific factors. These scores were measured using the validated Treatment-Related Impact Measure-Diabetes (TR Continue reading

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15 Tips on Diabetic Dog Food and How to Feed Dogs with Diabetes

Having a dog diagnosed with diabetes can be daunting. Fortunately, however, canine nutrition has come a long way in recent years. We now have a much better understanding of canine diabetes and the part that proper nutrition can play in it. Diabetic dog food can help you regulate your pet’s condition without a lot of medications.
Although a canine diabetes diagnosis can be scary, know that it is not the end of the world. Canine diabetes can be easily and effectively managed so long as you have the right tools and the plenty of knowledge on your side.
For this reason, it’s imperative that you work with your veterinarian, a canine nutritionist and any other member of your pet health team. Planning the right treatment for a diabetic dog is not something that you can do on your own.
Your veterinarian will be able to guide you in selecting the treatment plan that will meet your dog’s needs and your budget. This plan may include diabetic dog food, medication and a change in activity level. While it will require more effort on your part, caring for a diabetic dog is not as difficult as you may originally think.
ALSO READ: Dog Food for Dogs with Diabetes – What You Need to Know
15 Tips on Diabetic Dog Food
and how to feed dogs with diabetes
1. Talk to your vet about your diabetic dog’s diet
When your dog is first diagnosed with diabetes, the first thing you should do is talk to your vet about your dog’s diet. Depending on your dog’s current state of health, you may or may not need to make adjustments to the quantity or type of food that your dog eats.
Not all dogs with Continue reading

New measure of insulin-making cells could gauge diabetes progression, treatment

Researchers at the University of Wisconsin–Madison have developed a new measurement for the volume and activity of beta cells, the source of the sugar-regulating hormone insulin.
In a study published in the August edition of the journal Diabetes, Weibo Cai, Matthew J. Merrins and colleagues used a PET scanner to detect minute levels of a radioactive chemical in the mouse pancreas. Cai, the senior author of the study and an associate professor of radiology, says that unlike previous methods for measuring the quantity of beta cells, the new test also measures how actively these cells are making insulin.
PET scanning, or positron emission tomography, is used to detect minute quantities of tracers, commonly for finding cancer and metastases. This area is a specialty of Cai. Cai says the test may be used to evaluate treatments or cell transplants intended to slow or reverse diabetes.
With a provisional patent filed through the Wisconsin Alumni Research Foundation, Cai has begun planning a series of human trials that could lead to Food and Drug Administration clearance for a new method to determine the quantity and condition of the beta cells. The first step in these trials would look at the distribution and potential toxicity of the radioactive manganese chloride used as a tracer.
A shortage of insulin, due to the death or inactivity of the beta cells, causes type I (formerly “juvenile“) diabetes. The same problem can also cause type II diabetes. But this condition, once called “adult onset” diabetes, can also result from insufficient response to insulin. “In some co Continue reading

Whey protein could help control type 2 diabetes

Eating whey protein before breakfast could help prevent or control type 2 diabetes, two separate studies by Newcastle University have shown.
The findings, which were unveiled at the Diabetes UK Professional Conference, found obese men and males with type 2 diabetes had better blood sugar levels after eating the protein first thing. One of the studies also showed it helped stifle appetite.
The first study looked at how 20 grams of the whey protein affected 12 obese men, before they took part in 30 minutes of light walking and then ate a carbohydrate heavy breakfast. The researchers said the combination of the protein and exercise helped control blood sugars.
A total of 11 men with type 2 diabetes participated in the second study. They were given 15 grams of whey protein before breakfast and again, their blood sugars remained stable.
Lead researcher Dr Daniel West from Newcastle University said: “We know that high blood glucose levels after eating can contribute to poor blood glucose management and can also be detrimental to cardiovascular health.
“We’ve shown that consuming small amount of whey protein before a meal could help people avoid those high blood glucose levels and may help them to feel more satisfied after mealtimes.”
Diabetes UK’s director of research Dr Elizabeth Robertson said: “Finding ways to keep blood glucose levels as stable as possible after eating is an important area of scientific research, to help people manage their diabetes well. This new research adds to other small scale studies that have promising results.
“However, larger scale stud Continue reading

Throwdown: plant vs. animal protein for type 2 diabetes

Comparison of the effects of diets high in animal or plant protein on metabolic and cardiovascular markers in type 2 diabetes: A randomized clinical trial
The optimal diet for treating metabolic diseases like obesity and type 2 diabetes remains controversial, with evidence suggesting a variety of nutritional strategies that can be effective so long as people adhere to them. However, some interventions may be more effective than others. One strategy that’s gaining steam involves eating more protein.
Even though the term “high-protein diet” varies in definition from study to study, evidence to date supports the idea that eating more protein than the recommended daily allowance of 0.8 grams per kilogram bodyweight results in less hunger and a reduced appetite, increased energy expenditure, and a preservation or increase of lean body mass. A recent meta-analysis of 74 randomized controlled trials showed that eating a higher protein diet (27% vs. 18% of calories on average) significantly reduced several cardiometabolic risk factors, including body weight, BMI, waist circumference, blood pressure, triglycerides, and fasting insulin, while also significantly increasing HDL-cholesterol and satiety. A strong body of evidence supports the claim that a high-protein diet can facilitate dietary adherence, health improvement, and long-term fat loss.
But it’s possible that not all protein is the same when it comes to health. A meta-analysis of observational research totaling over half a million people suggests that animal protein is associated with an increased risk of developing Continue reading