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Untargeted Metabolomic Analysis In Naturally Occurring Canine Diabetes Mellitus Identifies Similarities To Human Type 1 Diabetes

Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes

Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes


Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes
Scientific Reports volume7, Articlenumber:9467 (2017) Cite this article
While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed serum metabolomic profiles of breed- and body weight-matched, diabetic (n = 6) and healthy (n = 6) dogs by liquid chromatography-mass spectrometry (LC-MS) profiling. We report distinct clustering of diabetic and control groups based on heat map analysis of known and unknown metabolites. Random forest classification identified 5/6 dogs per group correctly with overall out of bag error rate = 16.7%. Diabetic dogs demonstrated significant upregulation of glycolysis/gluconeogenesis intermediates (e.g., glucose/fructose, C6H12O6, keto-hexose, deoxy-hexose, (P < 0.01)), with significant downregulation of tryptophan metabolism metabolites (e.g., picolinic acid, indoxyl sulfate, anthranilate, (P < 0.01)). Multiple amino acids (AA), AA metabolites, and bile acids were also significantly lower in diabetic versus healthy dogs (P < 0.05) with the exception of the branched chain AA valine, which was elevated in diabetic animals (P < 0.05). Metabolomic profiles in diabetic versus healthy dogs shared similarities with those reported in human T1D (e.g., alterations in glycolysis/gluconeogensis metabolites, bile acids, and elevated branched chain AA). Fur Continue reading

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Quitting Smoking With Diabetes

Quitting Smoking With Diabetes


Pretty much anyone who smokes knows that its important to quit. Smoking affects so many aspects of your health, and it definitely has an impact on your diabetes management. But, according to the website Smokefree.gov , Many ex-smokers say quitting was the hardest thing they ever did. However, millions of Americans have quit smoking, so it can be done. Read on to learn the whys and hows of quitting smoking, and find out whats worked for others.
Think back to when you started smoking. Maybe you were a teenager or a young adult. Maybe you had friends or parents who smoked. You might have seen ads, TV shows, or movies that glamorized smoking. But once you start to smoke, its all too easy to get hooked, thanks to nicotine, an addictive substance found in tobacco. Nicotine can make you feel good, and it promotes relaxation and stress relief. It acts on the nervous system and the brain to boost levels of dopamine, a feel-good chemical.
The effects of nicotine wear off quickly, though, which is why someone who smokes feels the urge to light up frequently. Over time, the body starts to build up a tolerance, and more nicotine is needed to prevent feeling irritable or edgy, setting in motion a vicious cycle of dependency. If you smoke, chances are you reach for a cigarette when youre stressed out, anxious, or upset. Smoking provides quick relief and helps you calm down.
According to the American Cancer Society, two out of three smokers want to quit, and half try to quit every year, but most wont succeed without help. Nicotine causes a physical and emotional dependence thats tough Continue reading

Using Diet and Exercise to Control Diabetes | The Bridges at Warwick

Using Diet and Exercise to Control Diabetes | The Bridges at Warwick


Controlling Diabetes with Diet & Exercise
Diabetes is a widespread problem in America with 1.4 million Americans diagnosed with diabetes each year and even more left undiagnosed. According to the Center for Disease Control (CDC) , out of 29.1 million Americans with diabetes in 2012, only 21 million were diagnosed. Out of those who were ages 45 to 64, 13.4 million had diabetes and 11.2 million of those 65 and older were also affected by it, showing that as we age, the more the risk of diabetes increases. Fortunately, with education, and good diet and exercise habits, seniors can control and manage their diabetes.
According to Sue Sunderland, Executive Director at The Bridges at Warwick, a senior living community in Jamison, PA, those with type 2 diabetes can do quite a few things to help control their disease. Seniors who live with diabetes know that its more than possible to live a great life even with the disease. It just takes more self-care, she states. By following a meal plan that is healthy and by exercising regularly, seniors are able to control their blood sugar and reduce their risks for further complications that can possibly occur, such as heart disease or stroke.
As one of the most serious diseases, it is important to take action to put the control back in your own hands.
A common misconception about diabetes is that a special diet is needed in order to best control the disease. According to an article titled Diabetes Myths " from the American Diabetes Association, those with diabetes do not need to adhere to a specific and special diet, but simply need t Continue reading

Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy


Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
Nature Communicationsvolume8, Articlenumber:1777 (2017)
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.
Diabetes mellitus is one of the most challenging health problems of the twentieth century, affecting more than 285 million people in 2010, with an expected rise to 439 million by 2030 1 , 2 . A typical clinical pathological feature of diabetes is a disorder of glucose regulation, which results in sever Continue reading

How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies

How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies


How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies
When a person thinking about a disease, it creates a clear picture of what it is, and what it isnt. Lots of people suffers from many diseases and that affects their lifestyle. Diabetes is one of the most common problem that affects millions of people worldwide, one would expect the definition and classification of diabetes to be fairly straightforward. There are various questions come into the mind of diabetic patients. How to get rid of this problem and how to manage the blood sugar level naturally. There are various Natural Herbal Remedies to manage sugar level. Here we are discussing different diabetes herbal remedies
Before switch to the treatment of diabetes we will discuss about diabetes, its causes and management in Ayurveda.
Diabetes is chronic condition that causes a persons blood sugar level to become too high. It refers to a group of diseases that affect your body and how uses blood sugar (glucose). Glucose is vital source of energy for the cells that make up your muscles and tissues in body. Diabetes has serious effect on multiple organs like kidneys, heart, brain, blindness, nervous system. Therein are various complication s associated with diabetes.
Different factors responsible for diabetes like genetic and environment which influence development of its main types of diabetes called tupe1 and type 2 diabetes.
1. Type 1 diabetes In type one diabetes there is destruction of the insulin producing cells (Beta cells) of pancreas by immune system. It is mostly common in people under the age Continue reading

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