Type 1 Diabetes Risk May Come Down to Gut Bacteria Counts
Read Stomach Bacteria Could be an Early Type 1 Detector.
Some scientists decided to test whether the environmental conditions at the differing labs affected the rate of non-obese diabetes in the mice, according to Dr. Aleksander Kostic, an assistant investigator at Joslin Diabetes Center in Boston. They raised the mice in a completely sterile, germ-free environment, and found that the rate of non-obese diabetes quickly climbed upwards. They then transferred stool from mice raised in a non-sterile environment to mice raised in a sterile environment, and noticed that the rate of diabetes for the mice who received the transplanted stool went down.
This seemed to indicate that a lack of exposure to microbes was somehow having a severely detrimental effect on the immune system and preventing protection from Type 1 diabetes to mice that were genetically prone, Dr. Kostic said in a phone interview with Insulin Nation.
Read Why People with Type 1 Have Stomach Problems.
Findings like these have given rise to the hygiene hypothesis. This theory supposes that our immune systems are genetically designed to handle a certain load of exposure to microbes. As societys hygiene has improved, it has left the immune system with not enough to do, the theory goes, and it becomes more prone to attacking the body. This could have led to a rise in autoimmune diseases like Type 1 diabetes.
With this theory in mind, Dr. Kostic and others have observed that gut bacteria becomes less diverse in people with Type 1 a year before diagnosis. The guts of people with Type 1 become dominated by several Continue reading