Type 1 Diabetes Patients Retain Some Ability To Produce Insulin

Type 1 diabetes patients retain some ability to produce insulin

Type 1 diabetes patients retain some ability to produce insulin

GAINESVILLE - As an autoimmune disease, Type 1 diabetes has long been thought to result from a complete immune system killing of the insulin-producing beta cells within the pancreas. Now, University of Florida Health researchers have made a striking discovery: some of the pancreas’ ability to produce insulin may remain for decades in people with Type 1 diabetes.
After studying the pancreata of those with Type 1 diabetes, researchers found insulin levels were low to undetectable among most — an expected finding given the absolute need for insulin therapy for all such patients. However, researchers found the amount of proinsulin, a protein precursor to insulin, were at near-normal levels and comparable to people without diabetes. The researchers also noted a small number of insulin-positive cells remain in pancreata of long-term Type 1 diabetes patients. That observation raised the question of how these cells avoided destruction by the immune system.
These findings, published Sept. 5 in the journal Cell Metabolism, have important implications for questions ranging from why Type 1 diabetes develops to how the disease might be reversed or cured, said Mark Atkinson, Ph.D., director of the UF Diabetes Institute and a professor in the UF College of Medicine’s departments of pathology and pediatrics.
In Type 1 diabetes, the body’s immune system attacks insulin-producing islet cells in the pancreas. The pancreas produces insulin to control the level of sugar in the blood. Elevated and uncontrolled blood sugar levels can lead to a variety of complications and, if left untreat Continue reading

Rate this article
Total 1 ratings
The High-Tech Business of Diabetes

The High-Tech Business of Diabetes

Diabetes is big business. If you don't believe me, just Google the term "diabetes is big business" to see the headlines that agree. As of 2012, $245 billion was spent in the United States alone per year, and that has some people believing there will never be a cure—there is too much money in it. Maybe that's true, maybe not. But there are plenty of companies out there making products intended to help those afflicted.
What Is Diabetes?
Here's the quick, highly over-simplified primer on the disease if you're not up to speed. Diabetes mellitus, more often called just diabetes, maybe even DM, or "the diabeetus" if you're a fan of Wilford Brimley, comes in a few forms.
The first is called Type 1 (aka T1), a chronic autoimmune disorder where the pancreas can no longer effectively produce the insulin hormone needed to manage the glucose (sugar) a person eats, mainly from carbohydrates. If you can't make insulin, your body gets hyperglycemia—that's too much sugar (high blood glucose). On the converse, diabetics are also easily prone to hypoglycemia—not enough sugar—caused by taking too much insulin (thus the term "insulin shock"), or even missing a meal or getting too much activity. Type 1 used to be called juvenile diabetes because you can get it as a kid and then you have it the rest of your life. T1s are entirely dependent on insulin from an outside source; and taking the right dosage means constantly monitoring blood glucose level. There is no known cause of T1, but it's likely a mix of genetics and environment.
Type 2 (T2) diabetes was once considered "adult-onset diab Continue reading

Effortless Weight Loss With Diabetes Can Be Yours

Effortless Weight Loss With Diabetes Can Be Yours

Dropping 5 to 7% of your body weight can lower your blood sugar, blood pressure and cholesterol, but who says you have to go on a diet?
Here are eight simple changes to make that will help you drop weight without really trying:
Stop the Pop
Soda consumption can add pounds in a hurry. A majority of sodas and fruit-flavored drinks are sweetened with high-fructose corn syrup, which has been shown to cause weight gain and ultimately insulin resistance that can lead to metabolic syndrome and type 2 diabetes.
Soda is also high in calories. Substitute water instead, which is what your body is really craving anyway.
Walk Away From Bad Snacks
Snack foods, such as packaged cookies and cakes, crackers, chips, and doughnuts, are tempting, easy to eat and even easier to eat too much of. There's not a lot of nutrition in these snacks, and they are usually loaded with sugar and fat. If it's in a crinkly cellophane bag or brightly colored box, chances are it's a bad snack.
Eat a Green Thing
Or a red thing ... or an orange thing. Fruits and vegetables are nature's best snacks. They are low in calories, full of fiber, a great source of antioxidants and (with a few exceptions) virtually fat-free. What's not to like?
Don't Eat Anything Creamy
Creamy equals fatty. Cream soups, sauces, salad dressings, gravies, anything that shimmers, undulates or oozes is a waistline buster.
If it tops or coats another food source, it falls into the same category. Just step away.
Say No to Fried Foods
Grilling, baking or roasting food is much lower in calories than frying it in hot grease. Sure, fried food is c Continue reading

Saturated Fats, Diabetes and Carb/Sugar Consumption

Saturated Fats, Diabetes and Carb/Sugar Consumption

I received this detailed response to a recent video on my YouTube Channel about the documentary, What The Health. My response follows as a helpful guide, just in case you face a similar crisis with a friend or loved one down the road too. The YouTube video in question in this case is also at the bottom of the post if you’d like to watch it.
The Argument
TheAltruismActivist: Hello Paul. Addressing your concern about the recommendations and research on diabetes, I believe that you are not looking deep enough into the issue.
Just because eating a sugary meal raises one’s blood sugar does not mean that sugar is the cause and main culprit of diabetes. Looking into it a step deeper, you must consider why the body is insulin-resistant (which causes the high, uncontrolled blood sugar).
There is much proof that dietary saturated fat is a significant inducer of insulin resistance. Pouring sugar into an insulin-resistant person’s body will surely exacerbate the diabetic issues, but the sugar intake is not the cause. Dietary saturated fat is.
That is how Dr. Walter Kempner, many decades ago, cured type 2 diabetics with a diet composed of white rice, white sugar, fruit, and fruit juice. That is not a healthy diet, but it proves that sugar is not the issue while dietary saturated fat is.
Switching anyone from a standard Western diet to a cleaner diet like yours will improve their diabetes, but that doesn’t mean further benefits can’t be obtained from digging deeper into the root cause of insulin resistance. Let me know your thoughts and response!
Study various diets
Hello! Afte Continue reading

The Hidden Culprit behind Diabetes

The Hidden Culprit behind Diabetes

“Refined sugar” is a phrase that strikes fear in our hearts. As consumers, we’re all too familiar with America’s war on sugar. Deemed a “silent killer,” sugar is identified as a major cause of obesity, heart disease, and diabetes. The past decade has seen a cascade of sugar substitutes, including Splenda and a slew of other trendy packets that cheerfully promise “sugar free.” Is this really the entire story, though? For diabetics, and for those of us who want to maintain our health, there is yet another line on the nutrition label that is far too often overlooked.
Most people in America are aware of the dangers of type II diabetes. After all, almost one in every ten people in the country is diabetic. One in every five health care dollars is spent caring for people with diabetes. There’s no question about it — this disease is a national problem.
Type II diabetes is characterized by the body’s impaired ability to respond to insulin and subsequently metabolize sugar, or glucose. Ideally, whenever we eat, our bodies break food down into glucose, which is absorbed into the blood and taken up by muscle cells to be stored or burned for energy. There’s a catch, though. Glucose in the blood needs a key to get into our cells, and that key is insulin. Cells in the pancreas, called beta cells, are responsible for the secretion of insulin that regulates our blood sugar levels.
When blood sugar levels are always elevated from eating refined sugar, over time, the body stops responding to insulin — a condition called insulin resistance. Insulin resistance is the s Continue reading

No more pages to load

Popular Articles

  • Relative contribution of type 1 and type 2 diabetes loci to the genetic etiology of adult-onset, non-insulin-requiring autoimmune diabetes

    Abstract In adulthood, autoimmune diabetes can present as non-insulin-requiring diabetes, termed as ‘latent autoimmune diabetes in adults’ (LADA). In this study, we investigated established type 1 diabetes (T1D) and type 2 diabetes (T2D) genetic loci in a large cohort of LADA cases to assess where LADA is situated relative to these two well-characterized, classic forms of diabetes. We tested t ...

  • No More Finger Pricks for Some With Diabetes

    If you have type 2 diabetes, chances are you prick your finger once a day or so to check your blood sugar. But a growing body of evidence shows that for most type 2 diabetes patients, routinely tracking your blood sugar, or glucose, doesn’t make any difference for your health. The exception is patients taking insulin or a sulfonylurea drug such as glipizide (which goes by the brand name Glucotro ...

  • Add Some Flavor to Your Diabetes Meal Plan

    1 / 11 Use Portion Control Enhancing your food's flavors through condiments and spices is key to enjoying a healthy type 2 diabetes diet. But before you reach for the ketchup and mayo, know that some choices are a lot better for you than others. You'll also benefit from learning how to read nutrition labels and measuring servings carefully. "Most important is portion control," says Constance Brown ...

  • Some statins 'raise diabetes risk'

    Some drugs taken to protect the heart may increase the risk of developing type-2 diabetes, according to researchers in Canada. Their study of 1.5 million people, in the British Medical Journal, suggested powerful statins could increase the risk by 22% compared with weaker drugs. Atorvastatin was linked to one extra case of diabetes for every 160 patients treated. Experts said the benefits of stati ...

  • Broccoli extract may lower blood sugar among some with diabetes, study finds

    Nearly 30 million people in the United States have type 2 diabetes. Being overweight or obese increases the chances of developing diabetes. Both obesity and diabetes are linked to cancer . Findings from a new study published in the journal Science Translational Medicine suggest that sulforaphane, a phytochemical that has shown strong cancer-preventive actions in lab and clinical studies, might ...

  • Test may miss diabetes in some African-Americans

    More than 200 scientists from around the world teamed up to study the genetics of hemoglobin A1c (HbA1c), or "glycated hemoglobin", a measurement used by clinicians to diagnose and monitor diabetes. The authors report that they have identified 60 genetic variants that influence HbA1c measurements, as well as the ability of this test to diagnose diabetes. The gene variants, including one that could ...

  • Some Idahoans find lifestyle changes hard despite diabetes | Idaho Statesman

    That visit six years ago confirmed his suspicions with a diagnosis of Type 2 diabetes. His blood sugar level was in the 300s far above the 80-130 that the American Diabetes Association advises before meals, and the 180 recommended for an hour or two after. Mine was super, super high, said Kluchesky, a Twin Falls chaplain. Since then things have changed quite a bit, but I still have a hard time ...

  • Insulin price spike leaves diabetes patients in crisis

    A massive spike in insulin prices is causing a health crisis for millions of diabetes patients who depend on the lifesaving drug, doctors say. Now, after years of rapid increases having nothing to do with available supply and not matched elsewhere in the world, those in the U.S. insulin supply chain are blaming one another. Tens of thousands of medical professionals are engaged in an intricate the ...

  • A New Clinical Trial Just Made Diabetes Patients Insulin Independent

    New research involving pancreatic islet cell implants show promise in treating Type 1 Diabetes, a potentially debilitating form of the disease that affects more than a million people in the U.S. This new treatment might just spell the end for T1D. With Promising Potential No matter how modern the world has become, there are certain ailments that continue to persist. One of these is diabetes, and a ...

Related Articles