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The Dangers Of Yo-Yo Dieting

The Dangers of Yo-Yo Dieting

The Dangers of Yo-Yo Dieting


Weight cycling means losing weight, then regaining it, then repeating the cycle. When this weight loss is the result of dieting, the process is often called yo-yo dieting. New studies show that weight cycling contributes to heart disease and earlier death.
The doctors who preach lose weight to people with diabetes need to learn the dangers of weight cycling. Their prescriptions for weight loss may be doing more harm than good.
A new study in The New England Journal of Medicine found that, in patients with coronary heart disease (CHD), weight cycling was strongly associated with heart attacks, strokes, and death. Lead author Dr. Sripal Bangalore of New York University reported that the more weight subjects had lost and regained, the greater the risk.
The study reviewed records of roughly 9,500 people with heart disease. The data collection started in 2005. After a year of the study, participants continued to report their weight, among other factors, every six months.
Those whose weight had swung by an average of 8.5 pounds had a 124% increased risk of death, 117% increased risk of heart attack, and 136% increased risk of stroke compared to people whose weight had changed by 2 pounds or less. People with the greatest swings in weight also had a 78% increased risk of diabetes, even after correcting for all traditional risk factors.
The risk of weight cycling has been found before. In the Framingham Heart Study, which has been going on nearly 70 years, people whose weight swung up and down over the years were more likely to die of heart disease and strokes than people wi Continue reading

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The Philippines is a diabetes hotspot

The Philippines is a diabetes hotspot


Philippine Daily Inquirer / 05:10 AM January 09, 2018
The Philippines is considered one of the diabetes hot spots in the Western Pacific region, where the disease is already reaching epidemic proportions. Our government knows this too well, and the increased taxes on sugary drinks is just one of the steps being taken to stem the tide.
Sufficient public education is needed to make everyone aware of the lifestyle changes needed to prevent diabetes, or to detect it earlier, so it can be controlled before there is serious damage to vital organs like the heart, kidneys, brain, eyes, nerves, liversince practically all organs and tissues of the body are affected.
Were happy to learn that the Philippine Center for Diabetes Education Foundation, Inc. (PCDEF), founded and currently headed by Dr. Augusto Litonjua, was recognized as a Centre of Education by the International Diabetes Federation (IDF) and its School of Diabetes during its recent congress held in Abu Dhabi.
Dr. Litonjua is considered the Father of Philippine Endocrinology for having pioneered in treating patients with diabetes and other endocrine or hormone-related problems in the country.
The PCDEF, also known as the Diabetes Center Philippines, has been at the forefront of raising public awareness for diabetes in the Philippines for the past 25 years through its four major programsDiabetes Awareness Week, Camp Cope (for Type 1 diabetic children), Intensive Training Course for Diabetes Teams, and the National Assembly of Diabetes Educators. To date, it has established more than 200 training teams, based in major Continue reading

Diabetes, space-saving DNA, and a very important gene

Diabetes, space-saving DNA, and a very important gene

Last week, you might recall that we looked at a gene called PDX1, a critical DNA sequence that plays a role in the development of a certain type of diabetes—and the actual development of the pancreas in human embryos. Now, as Diabetes Awareness Month continues, let’s take a look at another gene with major implications for sugar regulation. This week we’re focusing on KLF11, an important player in histone modifications (more on that shortly) that can play a role in a rare form of diabetes known as Maturity Onset Diabetes of the Young (MODY).
Every cell in the body has a nearly identical set of genes, but when and where these genes are read helps determine the identity and function of any given cell. For example, a neuron in the brain uses genes that instruct it on how to be a neuron. It is equally important that this neuron ignore other genes that carry instructions that are unrelated to neuron function. To do this, our body has developed ways of controlling when a gene is read.
Histone modifications relate to one method of controlling access to genes. DNA is stored within our cells as a combination of both DNA and a class of proteins known as histones. Histones are like genetic “hair curlers,” in that DNA can be wound tightly around them. This allows large amounts of DNA (around 6 feet of DNA in a single cell!) to be stored in microscopic structures known as chromatin. This can be problematic, though, because tight winding of the DNA can leave genes inaccessible—they can’t be used if they’re too tightly wound up.
This is where histone modification comes into Continue reading

Is Celery Good or Bad for Diabetics?

Is Celery Good or Bad for Diabetics?


As diabetes is a complicated disease, diabetic patients have to be wary about what should they eat and what should they not eat. Devising an adequate meal plan is the most important way in which you can manage diabetes in an effective manner. As such, you have to be well-versed with what a food contains and what it does not contain in order to ensure that it does not affect your health in an adverse manner, particularly if you are a diabetic. In this article, we shall study and analyze more about eating celery and how celery might affect the meal plan of a person who happens to suffer from diabetes. So, come and join in for the article Is Celery Good or Bad for Diabetics?
Guideline for Including Celery in Your Diet
To begin with, let us first see the various essential nutrients and vitamins present in this green, leafy vegetable:
Essential nutrients present in celery include folate, manganese, iron, magnesium, phosphorous, calcium, etc.
It is a rich source of vitamins such as vitamin K, vitamin C, vitamin A, riboflavin, as well as vitamin B6.
It has very fewer calories, saturated fat, and cholesterol
The vegetable may be high in its total sodium content when compared to the other vegetables
Let us now delve into the advantages and disadvantages of including celery in the diet of a diabetic patient.
Benefits of Including Celery in a Diabetic Diet
The following are the advantages of including celery in your diet if you are someone who suffers from a condition like diabetes:
Celery is a rich source of several antioxidants. These, along with several above-mentioned Continue reading

Novo Nordisk: survival of the fittest applies in diabetes and obesity market

Novo Nordisk: survival of the fittest applies in diabetes and obesity market


Novo Nordisk: survival of the fittest applies in diabetes and obesity market
Diabetes specialist Novo Nordisk is feeling the heat from increasingly price conscious US payers. It needs next generation innovation and growth in emerging markets to keep ahead of competitors and meet demands of outcomes-focused payers.
For many years, Denmarks Novo Nordisk was the pharmaceutical company that could do no wrong by shareholders under the 16-year tenure of chief executive Lars Srensen, it achieved an unbroken run of nearly 50 quarters of double digit sales growth.
This great success was founded on successive innovation in insulin products and user-friendly insulin pen devices. The company also expanded into haemophilia and growth disorder treatments, all of which saw revenues rise year on year, its share price growing twelvefold between 2000 and 2016.
But this golden period came to an abrupt halt last year when newly-empowered pharmacy benefit managers (PBMs) began to demand major price cuts in the US market, which accounts for around 40% of global diabetes sales, and 51% of Novos revenues. Novo and competitors such as Sanofi and Eli Lilly were forced to give steep discounts or otherwise see their products delisted from reimbursed lists entirely.
This led to Novo cutting its longer-term forecast for sales growth twice: slashed from 15% to 5%, the move sparked an investor crisis of confidence which led to Lars Srensen stepping down from the CEO role two years early.
Novo isnt out of the woods yet in the US: there are continuing battles with PBMs, threats of new price transpa Continue reading

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