Study Suggests Link Between A1 Beta-casein And Type 1diabetes

Study suggests link between A1 beta-casein and type 1diabetes

Posted on October 31, 2017 by Keith Woodford
[The article below was intended to be published some weeks back at The Conversation. The Conversation is the online portal, funded by Universities in Australia, New Zealand and the UK, where academics are encouraged to communicate and converse with non-academics. However, this particular article was blocked at the last minute by the Senior Editor(s) at The Conversation, having previously been approved within their editorial system. The Senior Editor(s) felt that the interests of associated commercial parties, who might benefit from dissemination of the article, were too great. A fuller story of that publishing saga will be posted shortly.
The content, formatting and supporting links are shown as originally agreed with The Conversation and reflect the prior input of one of their editors. This article can be freely republished, with or withut this foreword, but retaining the title as posted here, and with acknowledgements as to source [https://keithwoodford.wordpress.com].
Type 1 diabetes, an autoimmune disease in which the body attacks its own insulin-producing cells, is on the rise globally.
Early evidence of an association between type 1 diabetes and a protein in cow milk, known as A1 beta-casein, was published in 2003 . However, the notion that the statistically strong association could be causal has remained controversial.
As part of a seven-person team, we have reviewed the overall evidence that links A1 beta-casein to type 1 diabetes. Our research brings forward new ways of looking at that evidence.
Type 1 diabetes i Continue reading

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Cancer and Diabetes: More Connections Than You Think

Cancer and Diabetes: More Connections Than You Think
Many people struggle with both diabetes and cancer at the same time.
As youve probably heard by now, City of Hope recently announced its goal to cure type 1 diabetes within six years, made possible in part through a generous gift from the Wanek family.
Theannouncement raises a natural question:
Why should City of Hope, a renowned cancer center, devote so much time, effort and resources to the study and treatment of diabetes? Aren't they very different diseases?
To begin with, a great many people struggle with both diabetes and cancer at the same time.
People with type 2 diabetes (the most common form) are twice as likely to develop liver or pancreatic cancer. They also run a higher-than-normal risk of developing colon, bladder and breast cancer. Diabetic women with breast cancer have a higher mortality rate than women with breast cancer alone. (Oddly, diabetic men run a lower risk of developing prostate cancer.)
Ever-growing research strongly suggests that none of this is random or coincidental. Rather, it's clear that, from biology to risk factors to treatment options, cancer and diabetes are intimately related in many ways.
Cancer and diabetes are two sides of the same coin, asserted DebbieThurmond,Ph.D. , Chair of the Department of Molecular and Cellular Endocrinology at CityofHope'sDiabetes&MetabolismResearchInstitute . They are disruptions of the body's normal metabolism.
That may help explain why obesity is a major risk factor for both diseases. Excess fat may begin that disruption process, as well as inc Continue reading

World Diabetes Day 2017: Mindfulness Musings for Daily Practice

This year’s theme for World Diabetes Day is Women and Diabetes, so I figured as one of the 11 million American women with diabetes , and a counselor who specializes in mindful approaches to living well with diabetes, I’d share a few concerns and ideas with the blogosphere, in hopes of touching a few of you with something of value….
Here’s the headline from the Non-Communicable Disease Alliance (NCDA), one of the organizations promoting awareness of our disease this year:
"Diabetes is the ninth leading cause of death in women globally, causing 2.1 million deaths each year. As a result of socioeconomic conditions, girls and women with diabetes experience barriers in accessing cost-effective diabetes prevention, early detection, diagnosis, treatment and care, particularly in developing countries."
When I read statements like this, my mind and heart sink into sad thoughts and dejected emotions. “What can I do to help such an enormous problem?” Recent outpouring of tangible assistance for those in the wake of our many natural disasters this year, give hope – and they give us something to DO, like send extra supplies or money for the valuable humanitarian efforts to keep our fellow diabetes tribe members alive.
What about the feelings that still linger? Feelings and thoughts of fear (what if I’m affected by the next disaster? Am I adequately prepared?), guilt (why not me? Could I do more?), anger (at institutions, governments, global warming, people who drive Hummers, etc), despair and/or indignation (this problem is all just too big, too much; life is hard enough Continue reading

Study advances efforts to screen all children for Type 1 diabetes

Study advances efforts to screen all children for Type 1 diabetes
Novel way to present pancreatic proteins increases the sensitivity of Type 1 Diabetes Tests
IMAGE:This is an illustration of the ZnT8 protein embedded in a fatty membrane and attached to the P-Gold Assay. view more
Researchers from the Johns Hopkins University School of Medicine, Stanford University and the University of Florida report the development of a novel antibody detection technology that holds promise for improving the accuracy of diagnostic tests for type 1 diabetes in young children and making populationwide screening practical.
In a report on the work , published in the Proceedings of the National Academy of Sciences on Sept. 5, the scientists say the technology enables screening for more autoimmune antibodies implicated in type 1 diabetes than current tests by incorporating a full-length pancreatic protein, called the pancreatic zinc transport 8 (ZnT8), that is targeted for autoimmune attack in people with the disease. By improving the accuracy of this test, researchers hope to catch the disease earlier and extend testing to all people. Type I diabetes, once known as juvenile diabetes, is a relatively rare form of the disorder in which the pancreas produces no insulin. It accounts for about 5 percent of all cases of diabetes in the United States.
"Although current tests are about 94 percent accurate in detecting the antibodies years before children and young adults lose all blood sugar control, they are not accurate enough to rely upon for populationwide screening, so current antibody test Continue reading

Osteoporosis and Diabetes: Pros and Cons to Antidiabetic Regimens

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Osteoporosis and Diabetes: Pros and Cons to Antidiabetic Regimens
Study aims to distinguish different antidiabetic drugs and their effect on osteoporosis in people with diabetes.
Osteoporosis and type 2 diabetes have recently been the focus of study in recent years. Osteoporosis is a bone condition defined by low bone mass, increased fragility, decreased bone quality, and an increased fracture risk. Research has shown that people with tyope 2 diabetes are at risk for developing osteoporosis and fractures. The incidence of fractures increases with age and therefore osteoporosis is most likely seen in individuals 50 years or older. The increase in fractures poses an increased mortality rate among patients with osteoporosis. This mortality rate is increased when people with type 2 diabetes develop osteoporosis.
There are many risk factors of osteoporosis and bone fractures. According to the World Health Organization, individuals with low bone mass and increased fragility are most susceptible to fractures and osteoporosis. The Nord-Trondelag Health Survey from Norway showed a dramatic increase in hip fractures among type 1 females. As such, the longer an individual is diagnosed with diabetes, the lower his or her bone mineral density (BMD) becomes. In addition, it has been reported that women with type 1 diabetes are more prone to developing fractures and ultimately osteoporosis when compared to females without diabetes. It is suggested that insulin plays a role in diabet Continue reading