Statins Related To Diabetes Progression For Obese Patients

Statins Related to Diabetes Progression for Obese Patients

Statin therapy may be elevating risk of type 2 diabetes in high-risk adults.
Statins or HMG-CoA reductase inhibitors provide several cardiovascular benefits in addition to lowering cholesterol. This could lead individuals to believe that statins may potentially aid in reducing diabetes risk. However, in numerous cardiovascular disease (CV) prevention studies, it has been consistently found that diabetes risk is increased with statin therapy. Because diabetes is not usually a direct measure in these CV disease studies, participants are often low-risk.
The following study aimed to evaluate the effect of statin therapy on diabetes patients who are considered high-risk. Population data was analyzed from a 3-year study called the Diabetes Prevention Program (DPP), and an extension of this study called the DPP Outcomes Study (DPPOS). The DPP is a randomized, controlled trial that studied the effect of lifestyle changes, metformin use, and placebo on high-risk patients with obesity or overweight. There were 3,234 participants randomized to receive 1 of the 3 interventions. Participants were included if they were older than 25 years of age, had obesity or were overweight, had high fasting blood sugar levels, and had impaired glucose tolerance. Following the DPP, participants were given the option to join the DPPOS extension study.
In both the DPP and DPPOS, use of statins and other medications was obtained through patient self-report at baseline and twice yearly at follow-up visits. Statin therapy along with hypertensive therapy was determined by the participants primary physi Continue reading

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HempWorx CBD Oil and Diabetes

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Almost HALF of the U.S population either has diabetes or have experienced pre-diabetes signs. This disease poses its own day-to-day health problems that are hard to deal with. However it likewise puts you at much-greater risk for heart disease, kidney failure, nerve damage, and numerous other disorders.
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Colorado Springs family adapts to reality of Type 1 diabetes as, one after one, children are diagnosed

Colorado Springs family adapts to reality of Type 1 diabetes as, one after one, children are diagnosed
March 19, 2017 Updated: March 21, 2017 at 11:40 pm
Siblings Melanie, McGuire, Emily and Ashley, all of whom have type 1 diabetes, goof off as parents Julie and Bubba Hayes watch at their home on Wednesday, February 1, 2017. Julie and Bubba Hayes have four out of five children with type 1 diabetes. Photo by Stacie Scott, The Gazette
It was a cold, wet California winter and Julie Hayes, her husband, Bubba, and their five kids all were laid low by a nasty stomach virus. When a week went by and 3-year-old Ashley hadn't rallied like her twin sister and the rest of the family, Hayes started to worry. The toddler was wetting the bed, which she hadn't done in at least a year, and though she ate nonstop, never seemed to get full. She'd sleep half the day and wake exhausted.
Hayes explained the examples of uncharacteristic behavior to the emergency room doctor, who peered into Ashley's eyes, had her stick out her tongue, and asked if diabetes ran in the family.
"I looked at him and said, 'I don't even know what diabetes is," Hayes said.
That, and life as she knew it, was about to change.
In one life-changing year, Colorado Springs native drops 100 pounds
Over the following eight years, three more of her children would be diagnosed with Type 1 diabetes, a scenario that - even among families with a history of the disease - defies medical odds and, in many ways, illustrates the mysteries at the heart of genetic dynamics.
"I can tell you that the great majority of families ha Continue reading

Swapping for Fructose: Effects of a Sugar Replacement on Diabetes

Researchers determine the effects of replacing glucose or sucrose with fructose on glucose, insulin, and triglyceride concentrations.
When you think about eating healthier, what do you think about limiting in your diet? Sugar? Carbohydrates? Both?
Over the years, sugar has gained a bad reputation. The bad sugar that usually comes to mind is sucrose, commonly known as table sugar. However, there are two other types of sugars: glucose and fructose. Glucose and fructose are referred to as simple sugars because they are made up of single sugar molecules. Joined together, glucose and fructose form sucrose.
Our bodies break down sucrose into the simple sugars glucose and fructose.
Glucose, our bodys preferred energy source, is often referred to as blood sugar because it circulates in our blood. When we eat, our body breaks down sugar and carbohydrates into glucose for energy. Our bodies can either use glucose immediately, or store it muscle or liver cells in the form of glycogen for later use.
Fructose is a sugar naturally found in fruits and vegetables. It differs from the other sugars because our bodies process it differently. Fructose is not our bodys preferred energy source and unlike glucose, it does not cause insulin to be released.
Our bodies need the hormone insulin so that glucose can be taken up into our cells for energy.
Individuals with diabetes either dont make enough insulin, or their bodies do not respond properly to the insulin that is produced. In some cases, it is a combination of both. In type 1 diabetes, which usually begins in childhood, the body att Continue reading

Diabetes Dyslipidemia

Faculty of Medical and Human Sciences, Institute of Human Development, University of Manchester, Manchester, UK
University Department of Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
University Department of Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Find articles by Prasanna Rao-Balakrishna
Faculty of Medical and Human Sciences, Institute of Human Development, University of Manchester, Manchester, UK
Weill Cornell Medicine-Qatar, Doha, Qatar
University Department of Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Author information Article notes Copyright and License information Disclaimer
Faculty of Medical and Human Sciences, Institute of Human Development, University of Manchester, Manchester, UK
University Department of Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK
Weill Cornell Medicine-Qatar, Doha, Qatar
Jonathan D. Schofield, Email: [email protected] .
This article has been cited by other articles in PMC.
Diabetes mellitus is associated with a considerably increased risk of premature atherosclerotic cardiovascular disease. Intensive glycemic control has essentially failed to significantly improve cardiovascular outcomes in clinical trials. Dyslipidemia is common in diabetes and there is strong evidence that chole Continue reading