Statin induced diabetes and its clinical implications
“Then comes the question, how do drugs, hygiene and animal magnetism heal? It may be affirmed that they do not heal, but only relieve suffering temporarily, exchanging one disease for another”.
Statins are one of the most widely prescribed groups of drugs in the world. Although statins have been shown to be beneficial in primary and secondary prevention of cardiovascular disease (CVD) in a number of trials, current reports of increased risk of type 2 diabetes with statin use are of concern. As a result of these reports, on February 28, 2012, the Food and Drug Administration added new safety label changes for the statin class of cholesterol-lowering drugs regarding the potential for increased hemoglobin A1c (HbA1c) and fasting plasma glucose. The present review discusses the evidence available from clinical trials and meta-analyses regarding possible diabetogenic effect of statins, probable mechanisms of this association and how these new observations might change clinical approach to statin use. Continue reading