Screening For Neonatal Diabetes At Day 5 Of Life Using Dried Blood Spot Glucose Measurement

Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement

, Volume 60, Issue11 , pp 21682173 | Cite as
Screening for neonatal diabetes at day 5 of life using dried blood spot glucose measurement
The majority of infants with neonatal diabetes mellitus present with severe ketoacidosis at a median of 6weeks. The treatment is very challenging and can result in severe neurological sequelae or death. The genetic defects that cause neonatal diabetes are present from birth. We aimed to assess if neonatal diabetes could be diagnosed earlier by measuring glucose in a dried blood spot collected on day 5 of life.
In this retrospective casecontrol study we retrieved blood spot cards from 11 infants with genetically confirmed neonatal diabetes (median age of diagnosis 6 [range 2112] days). For each case we also obtained one (n=5) or two (n=6) control blood spot cards collected on the same day. Glucose was measured on case and control blood spot cards. We established a normal range for random glucose at day 5 of life in 687 non-diabetic neonates.
All 11 neonates with diabetes had hyperglycaemia present on day 5 of life, with blood glucose levels ranging from 10.2mmol/l to >30mmol/l (normal range 3.26.0mmol/l). In six of these neonates the diagnosis of diabetes was made after screening at day 5, with the latest diagnosis made at 16weeks.
Neonatal diabetes can be detected on day 5 of life, preceding conventional diagnosis in most cases. Earlier diagnosis by systematic screening could lead to prompt genetic diagnosis and targeted treatment, thereby avoiding the most severe sequelae of hyperglycaemia in neonates.
Blood spotsGlucoseNeonatal d Continue reading

Rate this article

Total 1 ratings

Role of Medical Nutrition Therapy in the Management of Gestational Diabetes Mellitus

#Springer Science+Business Media New York 2016
Abstract Medical nutrition therapy (MNT) plays an impor-
tant role in the management of gestational diabetes mellitus
(GDM), and accordingly, it has a significant impact on women
and newborns. The primary objective of MNT is to ensure
adequate pregnancy weight gain and fetus growth while main-
taining euglycemia and avoiding ketones. However, the opti-
mal diet (energy content, macronutrient distribution, its qual-
ity and amount, among others) remains an outstanding ques-
tion. Overall, the nutritional requirements of GDM are similar
for all pregnancies, but special attention is paid to carbohy-
drates. Despite the classical intervention of restricting carbo-
hydrates, the latest evidence, although limited, seems to favor
a low-glycemic index diet. There is general agreement in the
literature about caloric restrictions in the case of being over-
weight or obese. Randomized controlled trials are necessary to
investigate the optimal MNT for GDM; this knowledge could
Keywords Carbohydrates .Diet .Gestational diabetes .
Gestational diabetes mellitus .Medical nutrition therapy .
Gestational diabetes mellitus (GDM) is a frequent metabolic
condition associated with pregnancy that leads to substantial
maternal and perinatal complications. Medical nutrition ther-
apy (MNT) remains the main strategy for the treatment of
gestational diabetes [1]. However, there is still insufficient
evidence as to which is the optimal type of dietary advice.
This paper revises the available evidence from studies on this
matter Continue reading

Today is World Diabetes Day

The journey to positive living with diabetes.
World Diabetes Day is celebrated annually on November 14.
It was created in 1991 in response to growing concerns about the escalating health threat posed by diabetes.
Hearing the diagnosis for the first time that you have diabetes can be overwhelming and may leave you with mixed emotions its stressful, it requires an entirely new approach to aspects such as lifestyle and diet, and its tough to manage.
But its perfectly possible to lead a healthy, fulfilling and active life with the right healthcare and family support, medication and personal attitude, explained Dr Ntsiki Molefe-Osman, Diabetes Medical Advisor at Lilly South Africa.
Diabetes comes in two types Type 1 and Type 2.
If you have Type 1 diabetes, your body is unable to produce sufficient insulin of its own in order to maintain healthy blood sugar levels in the body.
It usually begins in childhood or adolescence and is caused by a faulty autoimmune response that causes the body to destroy the pancreatic cells that produce insulin, which in turn leads to an insulin deficiency.
People with type 1 diabetes must take insulin as it is vital to staying healthy and achieving the most consistently normal sugar levels, and quality of life.
Theres no cure for type 1 diabetes although researchers are working on preventing the disease as well as the further destructive progression of the disease in people who are newly diagnosed.
Type 2 diabetes is far more common and according to the International Diabetes Federation (IDF), there were 2.28 million diagnosed cases of Continue reading

Diabetes Advocacy...Diabetes Terms

This site does not supply clinical treatment information or medical advice. Any advice or information you may receive through this website or our mailing lists is not guaranteed and should always be discussed with your health care provider . All links are provided for your convenience and further do not signify any endorsement on our behalf.
Addison's Disease is an autoimmune disease in which the adrenal glands (small glands located above the kidneys) do not work properly or stop working altogether. The adrenal glands produce many hormones, including cortisol, which helps the body maintain heart function, blood pressure control, and blood glucose control. Addisons disease sometimes occurs with type 1 diabetes.
Albuminuriais a conditions in which high levels of protein called albumin are found in the urine. Too much can often be a sign of early kidney disease.
Alternate Site Testing (AST) refers to using parts of the body other than the fingertips to obtain blood for blood glucose testing
Alpha Cells are found in the Islets of Langerhans within your pancreas. They are responsible for producing glucagon, a hormone which causes an increase in the blood sugar level.
Animal Insulin is the original form of insulin that was obtained from the pancreases of pigs and cows.
Autoimmune Disease is a disorder in which a person's own antibodies destroy body tissues, such as the beta cells in the pancreas
Basal. Your body usually needs a small amount of insulin to hold everything steady, even if you've not eaten food. On injections Continue reading

Linking Readmission, Reimbursement Exposes Complex Needs of Diabetes Patients

Linking Readmission, Reimbursement Exposes Complex Needs of Diabetes Patients
Coverage from the 2017 meeting of the American Association of Diabetes Educators.
Few elements of the Affordable Care Act (ACA) have forced health systems to rethink their role in patients lives like the penalties Medicare charges if they fare poorly on 30-day readmission rates.
While the Hospital Readmission Reduction Program has sparked debate since it started in 2012, it has forced healthcare staff to reach into the community, to ask why some patients land back in the hospital and others dont. With the earliest 30-day measures measuring how many returned after heart attacks, heart failure, and pneumonia, patients with diabetes quickly captured health systems attention since they were likely candidates for readmission.
What hospitals are learning, according to a speaker at the American Association of Diabetes Educators annual meeting in Indianapolis, Indiana, is that a patients diabetes may not be first on the list of health problems. That makes successful interventions complicated, and it often means that solutions must be customized to a patients unique needs.
Virginia Peragallo-Dittko, RN, CDE, BC-ADM, FAADE, executive director of the Diabetes and Obesity Institute of NYU Winthrop Hospital and professor of Medicine at Stony Brook School of Medicine, told educators gathered Saturday that the right model for reducing readmissions doesnt have the hospital at the topit has the community at the top.
Transitions are going to look different, she said. While the ACA has forced changes and thi Continue reading