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'Reverse Vaccine' For Type 1 Diabetes Seems To Pass Human Test

'Reverse vaccine' for Type 1 diabetes seems to pass human test

'Reverse vaccine' for Type 1 diabetes seems to pass human test

Attempts at new treatments and cures have focused on suppressing large portions of the immune system — sometimes using powerful drugs developed for other conditions, such as the blood cancer lymphoma. Steinman called this the "big hammer" approach.
"We're trying to do something different," he said. "We want to eliminate just the immune cells that attack the insulin-producing cells in the pancreas."
Steinman and his team designed a molecule that contained the gene for making proinsulin, the precursor to insulin. The molecule also included instructions for triggering the killer cells' response and then shutting it down.
If everything went as planned, the DNA molecule would suppress the killer cells and allow the pancreatic cells to function properly, producing insulin.
After successful trials with diabetic mice, the team prepared to test its vaccine on humans. They selected 80 volunteers ages 18 to 40 who had been diagnosed with Type 1 diabetes within the last five years. After that time, many Type 1 sufferers have already lost all of their insulin-producing cells, Steinman said. (Although many people with Type 1 diabetes are diagnosed as children, the researchers avoided testing their reverse vaccine on kids because of safety concerns.)
Two-thirds of the study volunteers received the reverse vaccine in one of four doses ranging from 0.3 to 6.0 milligrams. The rest of the volunteers got a placebo. Injections were made once a week for 12 weeks.
Throughout the study, both the experimental and placebo groups also received insulin replacement therapy. All subjects were monitore Continue reading

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Call to 'suspend' diabetes drug

Call to 'suspend' diabetes drug

A widely-used diabetes drug should be pulled from the market, European regulators say.
Avandia is used to control blood sugar levels in type 2 diabetes patients.
It was licensed 10 years ago and more than 100,000 patients in the UK use it despite on-going concerns linking it to heart problems.
After reviewing safety data, the European Medicines Agency said the benefits no longer outweighed the risks and it should be suspended.
The drug - generic name rosiglitazone - is also used in combination with other drugs under the names Avandamet and Avaglim.
Contrast
A spokeswoman for the regulator said: "Patients who are currently taking these medicines should make an appointment with their doctor to discuss suitable alternative treatments.
"Patients are advised not to stop their treatment without speaking to their doctor."
It should not take this long to come to a decision when there is evidence that people's lives may be at riskPeter Walsh, Action Against Medical Accidents
But the recommendation in Europe contrasts with the US where regulators have decided only to introduce tougher restrictions over its use - a verdict which they confirmed at the same time as the EMA announcement.
Avandia was originally licensed with warnings about the risks for patients with heart failure.
These were later expanded to include other heart problems after further research into its use.
The advice by an expert panel of advisers, who looked at the issue amid mounting concerns, will now be passed to the European Commission.
It may be several months before they make a final ruling, although it is unusua Continue reading

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