Relationship Between Risk Factors, Age, and Mortality in Type 1 Diabetes Patients
Management of non-glycemic cardiovascular disease risk factors may have increasing benefits in an aging type 1 diabetes patient population with long-term hyperglycemia.
The duration of diabetes and how well it is controlled are important factors for preventing type 1 diabetes complications and mortality. Evidence-based therapy and improvement in technology has led to a significantly higher life expectancy among T1D patients. As these patients live longer, risk for cardiovascular disease complications has increased. CVD is the major cause of death in patients with type 1 diabetes and accounts for approximately half of all deaths while the other half is as a result of non-CVD and other causes. Risk factors that lead to insulin resistance, such as high triglyceride, high LDL-cholesterol, low HDL cholesterol, high waist-to-hip ratio (WHR), and albuminuria are strong indicators of CVD in type 1 diabetes patients.
In the EURODIAB Prospective Cohort Study, 2,787 type 1 diabetes patients were studied over a 7-year period. Mortality causes were categorized as CVD, non-CVD and unknown. The analyses were adjusted for age and the length of time since diabetes was diagnosed and the most important risk factors were determined using a simultaneous and stepwise approach. Non-CVD causes had a higher annual mortality rate at 1.9 per 1,000 person-years [1.4–2.6], while mortality rate due to CVD causes was 1.4 per 1,000 person-years [1.01–2.08], and 1.7 [1.3–2.4] per 1,000 person-years for unknown causes. The results of the study showed that for younger diabetes age, non-CVD risk factors Continue reading