Predictors of Chronic Kidney Disease In Type 1 Diabetes
CKD risk not necessarily tied to albuminuria in patients with type 1 diabetes.
The International Diabetes Federation Diabetes Atlas estimated that by 2040 approximately 642 million people worldwide will be afflicted with diabetes. The incidence of type 1 diabetes, especially in children, continues to grow at a rate of 3% annually worldwide. Type 1 diabetes accounts for 7-12% of all diabetes cases globally.
One of the leading causes of morbidity and mortality in patients with diabetes is related to kidney disease. Chronic kidney disease is the major precipitating factor to end-stage renal disease and is associated with an increased risk for cardiovascular events, which remains the leading cause of death in patients with type 1 diabetes.
Retaining renal function in the diabetes patient population is a major goal for healthcare practitioners and regular evaluations of kidney function helps mitigate the risk of disease progression and gives practitioners the opportunity to intervene early. Increases in urinary albumin excretion rate (AER) is an early indicator of renal damage and may promote progression to macroalbuminuria and eventual decrease in glomerular filtration rate. However, recent studies have shown that a significant number of patients with type 1 diabetes are progressing to end-stage renal disease in the absence of albuminuria.
Researchers retrospectively analyzed over 2,600 patients with type 1 diabetes and normal renal function at baseline to evaluate predictors for the development of depressed renal function with or without albuminuria, or its single components, Continue reading