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Peptide Immunotherapy For Type 1 Diabetes: A Promising New Treatment

Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment

Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment


Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment
Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment
Peptide immunotherapy offers a more nuanced approach that may reduce the risk for adverse effects in persons with type 1 diabetes.
Type 1 diabetes is characterized by the autoimmune destruction of pancreatic beta cells, leading to progressively decreasing insulin secretion. As beta cells die, hyperglycemia becomes more persistent, and most persons with type 1 diabetes have chronic hyperglycemia and often suffer from complications such as nephropathy and retinopathy. At present, treatment for type 1 diabetes targets hyperglycemia, but does not affect the underlying autoimmune processes.1
Immunomodulatory treatment, or immunotherapy, seeks to influence the immunological pathways that mediate beta cell destruction.1 "In the field of type 1 diabetes, we've been actively searching for ways to induce disease remission so that we can limit beta cell death, preserve endogenous insulin secretion, and limit the need for insulin injections," Carmella Evans-Molina, MD, PhD, from the Center for Diabetes and Metabolic Diseases at Indiana University in Indianapolis, told Endocrinology Advisor.
Although more than 25 years has been spent investigating immunotherapy for type 1 diabetes, no agent has proven to be effective at inducing remission in type 1 diabetes with an acceptable safety profile. Advances in the understanding of autoimmune conditions have led to the development of antigen-specific immunotherapy (ASI) and a subset of ASI known as pep Continue reading

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GMOs Have Helped Fight Diabetes and Other Interesting Facts

GMOs Have Helped Fight Diabetes and Other Interesting Facts


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A place to share knowledge and better understand the world.
GMOs Have Helped Fight Diabetes and Other Interesting Facts
What are some interesting examples of GMOs (Genetically Modified Organisms)? originally appeared on Quora : the place to gain and share knowledge, empowering people to learn from others and better understand the world.
Answer by Janice Person , worked with & eaten GMO crops since 1996, currently works at Monsanto, on Quora :
With the buzz around genetically modified organisms over the past few years, it seems that not everyone knows about the most interesting GMOs. I have quite a few that I enjoy talking about and I frequently hear people ask why they havent heard of them before. So, Im going to walk through some of my favorites that are the type of genetically engineered products that most people mean when they say GMO.
INSULIN Few folks think about GMOs in the full set that science does, but insulin is considered the first GMO, before that it was sourced from taking the pancreas from animals [1] .Having had a diabetic or two in my extended family, the ability to produce insulin faster and easier, is something really rewarding and I frequently wonder how awesome it would feel to have been on that breakthrough team to develop something that proves to be lifesaving for others.
IN A NUTSHELL My favorite GMO is probably the American chestnut tree that the State University of New York College of Environmental Science and Forrestry has been working on. I grewup in a part Continue reading

New research links outdoor air temperature and risk of developing gestational diabetes

New research links outdoor air temperature and risk of developing gestational diabetes

TORONTO, May 15, 2017 - Women who were exposed to colder temperatures during pregnancy had a lower rate of gestational diabetes than those exposed to hotter temperatures, according to a study published online today in the Canadian Medical Association Journal.
The prevalence of gestational diabetes was 4.6 per cent among women exposed to extremely cold average temperatures (equal to or below -10 C) in the 30-day period prior to being screened for gestational diabetes, and increased to 7.7 per cent among those exposed to hot average temperatures (above 24 C). The study also found that for every 10-degree Celsius rise in temperature, women were six to nine per cent more likely to develop gestational diabetes.
The study examined 555,911 births among 396,828 women over a 12-year period. All the women studied lived in the Greater Toronto Area, but some were pregnant when the average temperature was warmer, and some when it was cooler.
Researchers looked at the relationship between the average 30-day air temperature prior to the time of gestational diabetes screening in the second trimester, and the likelihood of gestational diabetes diagnosis.
Dr. Gillian Booth, a researcher at St. Michael's and the Institute for Clinical Evaluative Sciences (ICES) and lead author of the study, said the finding might seem counterintuitive, but can be explained by emerging science about how humans make different kinds of fat.
"Many would think that in warmer temperatures, women are outside and more active, which would help limit the weight gain in pregnancy that predisposes a woman to gestational Continue reading

Diabetes in Hot Weather

Diabetes in Hot Weather


Diabetes Ireland > Diabetes in Hot Weather
In the current hot weather, it is possible to become dehydrated as we sweat more. Even a small fluid decrease of 2% can reduce the bodys ability to perform by affecting concentration and capacity to remember. Other affects of dehydration include fatigue, constipation and circulatory problems.
The groups most affected by a fluid decrease are the very young and the elderly.
Dehydration can be a problem in both of these groups because childrens feeling of thirst is not developed enough and with older people the thirst mechanism is declining.
Water is an essential part of life. The amount we need depends on our age, weight, diet, activity levels and climate.
It will vary from person to person but on average most adults need at least 1.5 to 2 litres of fluid daily (approx 3 pints)
Water makes up a very large part of the body for men about 60-70% of their body weight and women about 55-65% of their body weight.
Blood is 83% water, muscles are 75% water, the brain is 74% water and bone is 22% water.
The types of fluids to be discussed in the article are
Fruit juices, vegetable juices and smoothies
Diabetes Ireland recommend water as the best source of hydration.
A lot of the other fluids listed will contain carbohydrates.Carbohydrates (CHO) are made up of sugars and starches and when carbohydrates are digested they are all broken down to sugars (glucose)
It is important to remember it is the total amount of CHO that the person with Diabetes eats or drinks at one time that will have the biggest affect on the glucose level in Continue reading

Diabetes And Your Diet

Diabetes And Your Diet


More than 100 million people today have diabetes or pre-diabetes
More than 100 million people today have diabetes or pre-diabetes. A recent study conducted by a team of American and Japanese researchers shows that people who have diabetes can vastly improve their health by eating an entirely plant-based diet.1
During my work with people who have diabetes, I have found they show remarkable improvement in their health and well-being from consuming a plant-based and almost completely raw-food diet.
Diabetics who would like to reduce their medications can now understand that the type of food they eat has a direct impact on their health. In 2014, Cardiovascular Diagnosis and Therapy published a study in which researchers performed a meta-analysis of six significant prior research studies. Researchers found that a plant-based diet significantly improved blood sugar control in Type 2 diabetes.
The results were that plant-based diets improved a key indicator of blood sugar control, an indicator called Hemoglobin A1c. The results improved as much as 1.2 points, which is much greater than the effect of typical oral diabetes medicines.2 The benefits of excluding meat, cheese, and eggs from the diet was as much as 0.7 points in some of the studies, and averaged 0.4 points overall.
Dr. James Anderson studied 25 Type 1 and 25 Type 2 diabetics. This study involved placing the patients on a high-fiber, high- carbohydrate, low-fat diet in a hospital setting. Dr. Anderson initially put the patients on the American Diabetes Association recommended diet plan for one week. Then he switch Continue reading

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