New Stem Cell-based Implant Offers A ‘functional Cure’ For Type 1 Diabetes

New stem cell-based implant offers a ‘functional cure’ for Type 1 diabetes

New stem cell-based implant offers a ‘functional cure’ for Type 1 diabetes

We barely recovered from the excitement of editing human embryos in the U.S. but now the miracle of science has given us another reason to gape. Last week, two individuals with Type 1 diabetes received implants derived from embryonic stem cells in order to treat their chronic condition. This marks the first time that such an approach has been taken to curing diabetes.
The new implants, known as PEC-Direct from Viacyte, are expected to release inulin when patients’ blood sugar levels rise, thereby returning them to normal levels. The immune systems of Type 1 diabetes patients attack insulin-producing cells in the pancreas, resulting in abnormally low levels of the crucial hormone. While doctors and scientists have long searched for a way to replenish insulin in the human body (often with stem cells), they have been unsuccessful so far.
An implant, however, could be the answer. Scientists designed the new device to automatically release the hormone when it is needed, which allows stem cells to otherwise mature in the body while they are unneeded.
“If successful, this strategy could really change the way we treat Type 1 diabetes in the future,” Emily Burns of the charity Diabetes U.K said. This is actually comparable to another treatment method, in which pancreas cells from organ donors are introduced into patients’ bodies. However, given the lack of donors available, this is often not the most dependable of solutions.
Stem cells address this problem, as they can be produced in essentially infinite amounts.
“A limitless source of human insulin-producing cells would b Continue reading

Rate this article
Total 1 ratings
'I feel the pressure': Sanford presses on in attempt to cure Type 1 diabetes

'I feel the pressure': Sanford presses on in attempt to cure Type 1 diabetes

Dr. Kurt Griffin knows why he's pushing forward with Sanford Health's moonshot goal to cure Type 1 diabetes. He sees them every time they visit Sanford in Sioux Falls.
They are the handful of diabetic children serving as test subjects for an experimental therapy, eager to make a difference in the fight against their disease.
"I feel the pressure from seeing these kids in clinic," Griffin said. There's nothing I would like better than to put myself out of work."
Griffin is the director of clinical trials for The Sanford Project, the type 1 diabetes cure effort. The Project is amid a clinical trial known as the T-Rex Study. The trial has hit its halfway point, and Sanford is seeking more candidates to participate.
The clinical trial is dubbed the T-Rex Study because it tests the efficacy of using a patient's own regulatory T cells, called Tregs, to help fight type 1 diabetes.
Those who suffer from Type 1 diabetes have immune systems that mistakingly target cells that produce insulin, a hormone crucial to allowing blood sugar to feed a body's cells.
Did you know? Wochit
The disease steals peace, forcing sufferers into a lifetime of vigilance, closely monitoring blood sugar levels and responding with doses of insulin. It's a matter of life and death.
"That's not a cure, and that's really what we're after some day," said Griffin. "So that means we have to address the underlying problem, and the underlying problem is the immune system is out of balance."
The big question: Could diabetics fight off the disease by getting a boost of key cells, rebalancing their immune systems and p Continue reading

Biopharma Steps Up as Diabetes Epidemic Goes Global

Biopharma Steps Up as Diabetes Epidemic Goes Global

This May, the World Health Organization (WHO) named its new Director-General Dr. Tedros Adhanom Chebreyesus, the first African to ever lead the WHO. During his candidacy, he spoke powerfully about the challenges of people trying to survive with diabetes in low- and middle-income countries, including his native Ethiopia, where the Ethiopian Diabetes Association became the nation’s first patient-based association.
Today is World Diabetes Day, and the era when the disease was primarily a “wealthy nation” problem are over. In the developing world, we are witnessing a shift, where communicable diseases such as malaria are on the decline while chronic diseases like cancer and diabetes are on the rise. An estimated 422 million adults worldwide were living with diabetes in 2014, according to the WHO. Global prevalence has nearly doubled since 1980. Shockingly, nearly nine percent of the world’s adult population is now diabetic.
Rates are rising faster in low- and middle-income countries than in high-income countries. The greatest global increases are in Pacific island nations, followed by the Middle East and North Africa in countries like Egypt, Jordan and Saudi Arabia, according to a 2016 study. American Samoa had the highest diabetes rate in the world, with more than 30 percent of the population afflicted.
Globally, more than 11 percent of all adults with the disease live in China. Meanwhile, Pakistan, Mexico and Indonesia – where age-adjusted diabetes rates have doubled – are all now in the top 10 countries with the highest percentage of cases.
Here in the United Sta Continue reading

Study: Countries That Use More High Fructose Corn Syrup Have More Diabetes

Study: Countries That Use More High Fructose Corn Syrup Have More Diabetes

The 20 percent increase in type 2 diabetes is independent of total sugar consumption and obesity.
PROBLEM: Is high fructose corn syrup the harbinger of the health apocalypse? A review of the debate in the American Journal of Clinical Nutrition rejects HFCS as a causative factor of obesity, arguing that the processed stuff, though scary-sounding, "is not meaningfully different in composition or metabolism from other fructose-glucose sweeteners like sucrose, honey, and fruit juice concentrates." But those in the anti-HFCS camp aren't convinced, and would insist there's still plenty to be wary of -- they point to diabetes as another public health concern whose rise parallels the increased prevalence of HFCS in foods and beverages.
METHODOLOGY: "It's very hard to study the effects of high fructose corn syrup on overall health," explained lead author Michael Goran, Professor of Preventive Medicine, Physiology and Biophysics, and Pediatrics at USC, "Because we simply don't know how much we're consuming, even in the U.S." So he and fellow researchers at USC and Oxford took a broader, population-based approach, looking at estimates for the prevalence of type 2 diabetes -- culled from two independent sources -- as related to the availability of HFCS in 43 countries. They also looked at the total availability of sugar and calories, along with estimated rates of obesity and impaired glucose tolerance, and each country's GDP.
RESULTS: "All indicators of diabetes were higher in countries that use HFCS as compared to those that do not," with type 2 diabetes occurring in 8 percent of the Continue reading

Diabetes’ JDRF Tries Shock Ad to Push the FDA

Diabetes’ JDRF Tries Shock Ad to Push the FDA

This is not a story about statistics, yet I have to start there. It is not a story about a shocking ad that ran in the New York Times and Washington Post, yet the uproar started there.
This is the story of how approximately 150,000 people with type 1 diabetes will die, and one among them, a vibrant, healthy and lovely 17-year-old girl who did die, due to a side effect of insulin.
Insulin, which many think is a cure for type 1 diabetes, is not a cure but a medicine that lowers blood sugar. Sometimes so much, that you die. Did you know that?
This ad ran on Nov. 2 and touched off seismic aftershocks among diabetes bloggers and online advocates.
Most who read the ad were stunned. Parents who have a child with diabetes were terrified or angered. The emotional-hit prompted many to question such an unbelievable figure: 1 in 20 people (an estimated 2-4 percent and 6 percent in patients younger than 40 years old) will perish from severe hypoglycemia.
Of the estimated 3 million people in the U.S. with type 1 diabetes, that’s approximately 150,000 people. That’s like wiping out Chattanooga, Tenn. or Rockford, Ill. — wiping them right off the map.
Aaron Kowalski, Juvenile Diabetes Research Foundation (JDRF) vice president, who’s been in charge of hypoglycemia research funding and helped launch, and still oversees, the Artificial Pancreas Project immediately responded to the uproar online.
He said JDRF ran the ad because they want the FDA to understand that tools and technologies, such as artificial pancreas technologies, exist to minimize dangerous low blood sugar; that researc Continue reading

No more pages to load

Popular Articles

  • Pouch of stem cells implanted in trial to cure type 1 diabetes

    Viacyte, privately-held, leading regenerative medicine company, announced today that the first patients have been implanted with the PEC-Direct™ product candidate, a novel islet cell replacement therapy in development as a functional cure for patients with type 1 diabetes who are at high risk for acute life-threatening complications. The first implant procedures of the clinical trial took place ...

  • A Quest: Insulin-Releasing Implant For Type-1 Diabetes

    Scientists in California think they may have found a way to transplant insulin-producing cells into diabetic patients who lack those cells — and protect the little insulin-producers from immune rejection. Their system, one of several promising approaches under development, hasn't yet been tested in people. But if it works, it could make living with diabetes much less of a burden. For now, patien ...

  • Removable implant may control type 1 diabetes

    For the more than 1 million Americans who live with type 1 diabetes, daily insulin injections are literally a matter of life and death. And while there is no cure, a Cornell-led research team has developed a device that could revolutionize management of the disease. In Type 1 diabetes, insulin-producing pancreatic cell clusters (islets) are destroyed by the body’s immune system. The research gro ...

  • Hope of cure for arthritis, MS and diabetes as Stanford makes stem cell transplants safe

    Hundreds of thousands of people could be cured of autoimmune diseases like arthritis, multiple sclerosis, diabetes and lupus after scientists discovered how to make stem cell transplants safe. Autoimmune diseases trigger the body into attacking itself but transplants of bone marrow stem cells from healthy donors have been shown to reset the immune system and reverse fatal conditions. However docto ...

  • Stem cells from our own bodies could cure MS and diabetes | Daily Mail Online

    Zoe Derrick was 'cured' of MS after getting stem cell treatment in Mexico But when Gregg Burgess-Salisbury, from Berkshire, had stem cell treatment two years ago it didn't work, and he is still confined to a wheelchair Steve Storey, from Sheffield, was paralysed with MS but had successful therapy Experts warn the risky and invasive treatment is a lottery for patients Stem cells could cure di ...

  • Stem Cells Of Type 1 Diabetes Patients Transformed Into Insulin-Secreting Beta Cells; Research May Lead To New Therapy

    For those living with Type 1 diabetes, the condition is a part of daily life. Insulin shots, blood sugar monitoring, and carb counting become routine, and patients expect them to stay so for the rest of their lives. This form of diabetes currently has no cure, something researchers have been diligently trying to change. The most recent attempt to take down diabetes comes from researchers at Washin ...

  • New Stem Cell Treatment "Switches Off" Type 1 Diabetes

    For those with type 1 diabetes, regularly injecting themselves with insulin is part and parcel of their daily lives. This form of treatment hasn’t advanced much for nearly a century, so it will come as good news that researchers at the Massachusetts Institute of Technology (MIT) are on the verge of a breakthrough. As a study in Nature Medicine reveals, insulin-producing beta cells made from huma ...

  • Fighting diabetes with new rice strains to help China stem growing scourge

    Fighting diabetes with new rice strains to help China stem growing scourge Samples of rice developed by Li Jianyue, professor of life and environment sciences at Shanghai Normal University, sit in bags in an arranged photograph in Shanghai, China, on May 10, 2017.PHOTO: BLOOMBERG BEIJING (BLOOMBERG) - With a stack of small, brown envelopes in hand, Li Jianyue trudges through a rice field in so ...

  • Diabetes Type 2 - Stem cells treatment clinic

    Diabetes Type 2 Stem Cell Treatment Diabetes type 2 is a metabolic disorder that is characterized by high blood sugar and lack of insulin, a hormone produced in the pancreas that regulates the metabolism of carbohydrates. It is typically a chronic disease with a ten-year shortened life expectancy and symptoms such as: increased thirst, frequent urination, and constant hunger. There are a number of ...

Related Articles