
New alginate skin patch for type 2 diabetes
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New alginate skin patch for type 2 diabetes
Concept illustration of microneedle device for type 2 diabetes treatment. Chen lab, NIBIB.
or millions of people with type 2 diabetes, ongoing vigilance over the amount of sugar, or glucose, in their blood is the key to health. A finger prick before mealtimes and maybe an insulin injection is an uncomfortable but necessary routine.
Researchers with NIHs National Institute of Biomedical Imaging and Bioengineering (NIBIB) have devised an innovative biochemical formula of mineralized compounds that interacts in the bloodstream to regulate blood sugar for days at a time. In a proof-of-concept study performed with mice, the researchers showed that the biochemically formulated patch of dissolvable microneedles can respond to blood chemistry to manage glucose automatically.
This experimental approach could be a way to take advantage of the fact that persons with type 2 diabetes can still produce some insulin, said Richard Leapman, Ph.D., NIBIB scientific director. A weekly microneedle patch application would also be less complicated and painful than routines that require frequent blood testing.
Global incidence of all types of diabetes is about 285 million people, of which 90 percent have type 2 diabetes. Many require insulin therapy thatis usually given by injection just under the skin in amounts that are calculated according to the deficit in naturally generated insulin in the blood. Insulin therapy is not managed well in half of all cases.
NIBIB researchers led
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