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Microneedle-array Patches Loaded With Dual Mineralized Protein/peptide Particles For Type 2 Diabetes Therapy

Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy

Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy


Microneedle-array patches loaded with dual mineralized protein/peptide particles for type 2 diabetes therapy
Nature Communicationsvolume8, Articlenumber:1777 (2017)
The delivery of therapeutic peptides for diabetes therapy is compromised by short half-lives of drugs with the consequent need for multiple daily injections that reduce patient compliance and increase treatment cost. In this study, we demonstrate a smart exendin-4 (Ex4) delivery device based on microneedle (MN)-array patches integrated with dual mineralized particles separately containing Ex4 and glucose oxidase (GOx). The dual mineralized particle-based system can specifically release Ex4 while immobilizing GOx as a result of the differential response to the microenvironment induced by biological stimuli. In this manner, the system enables glucose-responsive and closed-loop release to significantly improve Ex4 therapeutic performance. Moreover, integration of mineralized particles can enhance the mechanical strength of alginate-based MN by crosslinking to facilitate skin penetration, thus supporting painless and non-invasive transdermal administration. We believe this smart glucose-responsive Ex4 delivery holds great promise for type 2 diabetes therapy by providing safe, long-term, and on-demand Ex4 therapy.
Diabetes mellitus is one of the most challenging health problems of the twentieth century, affecting more than 285 million people in 2010, with an expected rise to 439 million by 2030 1 , 2 . A typical clinical pathological feature of diabetes is a disorder of glucose regulation, which results in sever Continue reading

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How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies

How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies


How to Manage Blood Sugar Level In Ayurveda-Diabetes herbal Remedies
When a person thinking about a disease, it creates a clear picture of what it is, and what it isnt. Lots of people suffers from many diseases and that affects their lifestyle. Diabetes is one of the most common problem that affects millions of people worldwide, one would expect the definition and classification of diabetes to be fairly straightforward. There are various questions come into the mind of diabetic patients. How to get rid of this problem and how to manage the blood sugar level naturally. There are various Natural Herbal Remedies to manage sugar level. Here we are discussing different diabetes herbal remedies
Before switch to the treatment of diabetes we will discuss about diabetes, its causes and management in Ayurveda.
Diabetes is chronic condition that causes a persons blood sugar level to become too high. It refers to a group of diseases that affect your body and how uses blood sugar (glucose). Glucose is vital source of energy for the cells that make up your muscles and tissues in body. Diabetes has serious effect on multiple organs like kidneys, heart, brain, blindness, nervous system. Therein are various complication s associated with diabetes.
Different factors responsible for diabetes like genetic and environment which influence development of its main types of diabetes called tupe1 and type 2 diabetes.
1. Type 1 diabetes In type one diabetes there is destruction of the insulin producing cells (Beta cells) of pancreas by immune system. It is mostly common in people under the age Continue reading

Asians With Type 2 Diabetes At Greater Risk Of Cancer

Asians With Type 2 Diabetes At Greater Risk Of Cancer

AsianScientist (Mar. 20, 2017) – Type 2 diabetes (T2D) is associated with a 26 percent increase in the risk of death from cancer in Asians, as well as increases in the risk of death from site-specific cancers that can be even greater. These findings have been published in Diabetologia.
There is increasing evidence of an association between T2D and an individual’s risk of developing cancer or dying from the disease. Most of the studies into this relationship have looked only at Western populations, but with diabetes becoming increasingly prevalent throughout Asia, it is important to understand whether the risk of developing cancer in Asians with T2D is similar to that seen in the West, or whether they face different, and possibly greater risks than white western populations.
Earlier research had suggested that at any given body mass index (BMI), Asians are more susceptible to developing insulin resistance, and go on to have a higher prevalence of T2D in comparison with people of European extraction.
Although there have been previous studies of diabetes and site-specific cancer risk in East Asian populations, the majority only considered one or a few cancer types, included only a small number of patients with diabetes, or didn’t control for other important risk factors such as obesity.
Data for this new study were drawn from the Asia Cohort Consortium, an international effort which combines 29 cohorts to examine the relationship between genetics, environment, and disease in a population of more than one million people. From that, 19 cohorts were chosen and further refin Continue reading

What Is Your Biggest Diabetes Fear?

What Is Your Biggest Diabetes Fear?


What would be or what is your biggest fear in dealing with diabetes?
This was the question I posed to the diabetes community to find out what their biggest fears were. I also shared with them my biggest fear and the fears that already occurred.
My Fear: Weve experienced a lot throughout these short almost 7 years since my sons diagnosis . In his first year of being diagnosed he was put on a sliding scale (which I learned I HATE ) and passed out from a low blood sugar , his sister (who was 4 at the time) found him unconscious in his room. This was only 2 months into diagnosis and I had to give glucagon.
After that scare, fast forward two months later (4 months into DX) he was acting strange so I tested, he was 143. My husband thought he was misbehaving but to me it felt like something was just off or not right about him so I made him come downstairs with me so I could monitor him closer. I tested him again 15 mins later and he was 99, I thought geez thats a big drop so we gave him a juice box. Not but 5-7 minutes later he suffered a seizure.
Diabetes Experts Share Ways To Lower Your A1C Levels
My husband called 911 and an ambulance was on the way but I tested during this time and he was 43, just like that. After this hospital stay they realized his sliding scale was too high (ya think??) I asked this the first time but they looked at me like I didnt know what I was talking about, you know we were only 2 months in. Since that day, weve had our fair share of crappy days with T1D (Highs, and lows, and a second diagnosis of my daughter), but nothing (thank god) as frighte Continue reading

Managing diabetes to live a longer, healthier life

Managing diabetes to live a longer, healthier life

November is National Diabetes Month. Learn to manage your diabetes for a longer, healthier life. Diabetes has no cure, but a healthy lifestyle can reduce its impact on your life. Make a difference with what you do every day: eat healthy diet, get physically active, take medications as prescribed, and keep health care appointments to stay on track.
The basics of diabetes
According to the Centers for Disease Control, more than 30 million people in the United States have diabetes and one out of four of them don’t even know they have it. There are three types of diabetes: type 1, type 2, and gestational diabetes (diabetes during pregnancy).
With type 1 diabetes, your body is unable to make insulin. If you are a type 1 diabetic, you will have to take insulin every day. Insulin is a hormone that acts like a key to let blood sugar into cells to be used for energy. Type 1 diabetes is less common than type 2 (less than 5 percent of those with diabetes have type 1). There is no known prevention for type 1 diabetes.
Nine out of 10 people with diabetes have type 2. At least one out of three people will develop diabetes in their lifetime. With type 2 diabetes, your body doesn’t use insulin well and is unable to keep blood sugar at normal levels. Knowing you have diabetes and making healthy changes will benefit you now and in the future. Risk of death for adults with diabetes is 50 percent higher than for adults without diabetes.
Risk Factors for Diabetes
Risk factors for type 2 diabetes include:
· Having prediabetes (blood sugar levels higher than normal, but not high enough to be Continue reading

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