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Mass. General Hospital Launches Phase II Trial Of BCG Vaccine To Reverse Type 1 Diabetes

Mass. General Hospital launches phase II trial of BCG vaccine to reverse type 1 diabetes

Mass. General Hospital launches phase II trial of BCG vaccine to reverse type 1 diabetes


Mass. General Hospital launches phase II trial of BCG vaccine to reverse type 1 diabetes
FDA approval of trial testing generic vaccine announced at ADA Scientific Sessions
A phase II clinical trial testing the ability of the generic vaccine bacillus Calmette-Gurin (BCG) to reverse advanced type 1 diabetes has received approval from the U.S. Food and Drug Administration (FDA). The approval of this trial, which will shortly begin enrolling qualified patients, was announced today at the 75th Scientific Sessions of the American Diabetes Association (ADA) by Denise Faustman, MD, PhD, director of the Massachusetts General Hospital (MGH) Immunobiology Laboratory and principal investigator of the study.
The five-year trial will investigate whether repeat BCG vaccination can clinically improve type 1 diabetes in adults between 18 and 60 years of age who have small but still detectable levels of insulin secretion from the pancreas. Faustmans research team was the first group to document reversal of advanced type 1 diabetes in mice and subsequently completed a successful phase I human clinical trial of BCG vaccination. She announced the FDA approval to launch the phase II trial during her ADA presentation, Low Levels of C-Peptide Have Clinical Significance for Established Type 1 Diabetes.
We have learned a lot since the early studies in mice not just about how BCG works but also about its potential therapeutic benefits, similar to what are being seen in trials against other autoimmune diseases, says Faustman. We are so grateful to all of the donors, large and small, who have ma Continue reading

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Cocoa compound could 'delay or prevent' type 2 diabetes

Cocoa compound could 'delay or prevent' type 2 diabetes


Cocoa compound could 'delay or prevent' type 2 diabetes
Cocoa powder antioxidants may help slow diabetes' progression.
With diabetes reaching epidemic proportions, the search is on for innovative ways to reduce the burden. Breaking research finds hope in the most surprising of places- chocolate.
Today, there are an estimated 29 million Americans living with diabetes , with the vast majority of cases beingtype 2 diabetes. Globally, by 2035, there could be 592 million people with diabetes. This is no small problem.
Beyond those Americans who already have a diabetes diagnosis, a further 86 million adults - more than 1 in 3 Americans - have prediabetes, a precursor to the disease. Without intervention (diet and exercise), diabetes is likely to be the next step for these individuals, often within 5 years.
Diabetes is costly in human terms, of course, but it is also a huge financial drain; in 2012, diabetes and itscomplications accounted for $245 billion in total medical costs and lost work and wages, up from $174 billion just 5 years earlier.The statistics are overwhelming.
Although type 2 diabetes is largely preventablethrough lifestyle choices, at this point in time, more needs to be done to stemthe flow and turn the tide.
Finding potential medical interventions for people at risk of developing type 2 diabetes is more pressing than ever. Research, recently published in The Journal of Nutritional Biochemistry , investigates whether a compound found in cocoa could be useful in the fight.
At the root of diabetes is the hormone insulin , which is produced, stored, and re Continue reading

My Diabetes Coach - A Holistic Care Management Solution - Macadamian

My Diabetes Coach - A Holistic Care Management Solution - Macadamian


My Diabetes Coach A Holistic Care Management Solution
The My Diabetes Coach solution is designed to improve and strengthen the teamwork between parent and child in diabetes management. Establishing and encouraging good practices and patient compliance at an early stage will provide significant benefits to the patients over the years by mitigating the complications that can result from non-compliance.
Most diabetes management solutions on the market today function as logbooks for keeping track of blood glucose levels and some connect to Bluetooth enabled glucometers to make the collection of this data quite simple. However, as anyone with diabetes knows, the measurement of blood glucose levels alone do not paint the entire picture of your condition or your progress towards meeting goals set by your clinician. Diet, exercise, sleep, stress, body weight, and medication compliance all play an important role in mitigating the impacts of the disease but these can be daunting to manage for anyone suffering from diabetes, let alone a youth or young adult recently diagnosed.
Along with contributions from the Childrens Hospital of Eastern Ontario, Healthwise, & the University of Ottawa, weve developed a diabetes care management solution that builds upon the features of many logbook applications as part of a larger, more holistic solution that gains context from multiple devices and patient data to help youth with type 2 diabetes better manage their care.
At its core, My Diabetes Coach is a cloud application that leverages a companion mobile app to collect data from a variety o Continue reading

Nursing Care Plan for Diabetes

Nursing Care Plan for Diabetes


Grab Free Cheat Sheet Quick! Is this aPTT Count Dangerous? Hesitant? Never Feel Anxious About Lab Values Again...
Diabetes Mellitus is when blood glucose (sugar in the blood) is unable to move into the cells and help in the making of ATPAKA energy. The body makes insulin to assist with this process. Insulin is a hormone that allows the sugar in the blood to move across the cell wall so the body can use to to produce ATP. There are two types of diabetes. Type I and Type II.
Type I is an autoimmune disorder where the cells attack the insulin producing cells in the pancreas. Thus the body is producing very little or no insulin leaving the sugar in the blood and the cells starve.
Type II is when the cells dont respond to the insulin trying to get sugar into them, called insulin resistance. Thus the sugar stays in the blood and the cells starve.
The cause for Type I diabetes is unknown, but hypothesized to be potentially genetic or triggered by a virus. The cause for Type II diabetes is caused by a storm of events culminating such as weight gain, lack of activity, genetics, and stress levels.
Blood sugar control with minimal side effects.
Diabetes Mellitus (Type I and Type II) Nursing Care Plan
Blood sugar monitoring: Normal range 70-180 mg/dL *patient may have a different target blood sugar level, make sure to know what each patients target is.
The physician will make a target blood glucose level. Teach the patient that they need to monitor their blood glucose.They need to call their primary care physician if they have blood glucose levels higher than their target fo Continue reading

Fresh fish oil lowers diabetes risk in rat offspring

Fresh fish oil lowers diabetes risk in rat offspring


Fresh fish oil lowers diabetes risk in rat offspring
July 19, 2017 by Pete Barnao, University of Auckland
Fresh fish oil given to overweight pregnant rats prevented their offspring from developing a major diabetes risk factor, Auckland researchers have found.
The pregnant rats were fed either a high-fat diet to make them overweight, or a standard diet, and half from each group were also given fresh fish oil. In the offspring of the high-fat group, the fish oil treatment improved the way insulin works, which is protective against diabetes.
"This is exciting because it raises the question: if overweight women take fresh fish oil in pregnancy, will it lower the risk of their children later developing diabetes?" says Dr Ben Albert, who led the research with Professor Wayne Cutfield, both at the University of Auckland-based Liggins Institute.
But he cautions against pregnant women taking fish oil on the basis of this finding - yet.
"The same benefit has not yet been shown in humans, and our earlier study shows New Zealanders cannot be sure that the fish oil they buy is fresh."
The current findings, published in high-ranking journal Scientific Reports, are part of a series of studies by the same team into the potential of omega 3 in fish oil to reduce the risk of diabetes and other obesity-related illnesses.
"Studies by other researchers using adult rats have shown that omega 3 fatty acids in fresh fish oil improve the way insulin works, which protects against diabetes and related diseases," says Dr Albert. "We wondered if it could also be protective during pregnancy, p Continue reading

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