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Long-Acting Insulins Useful Tools In Type 1 And Type 2 Diabetes

Long-Acting Insulins Useful Tools in Type 1 and Type 2 Diabetes

Long-Acting Insulins Useful Tools in Type 1 and Type 2 Diabetes

Researchers have augmented insulin's effectiveness with several rapid and long-acting analogues and new delivery systems such as insulin pens and insulin pumps. Biosynthetic preparations with various pharmacokinetic profiles somewhat mimic the steady insulin release from a normal pancreas. Long-acting insulins create unprecedented prescribing flexibility, as prescribers can tailor patients' regimens to their individual activity levels, eating habits, and responses to insulin.
Insulin is a necessity for patients who have type 1 diabetes (T1D). For many people who have type 2 diabetes (T2D), insulin can improve glycemic control significantly. Still, many clinicians are reluctant to initiate injectable glucose-lowering therapies in T2D. They often perceive, rationally or irrationally, that patients will have difficulty understanding complex regimens. Many clinicians also report that they are less proficient than they would like with insulin, creating discomfort with diabetes management.1 And they perceive that multidose insulin regimens may be associated with increased episodes of hypoglycemia, though they are not.2 However, today's long-acting insulins such as insulin detemir, insulin glargine (IGlar), and insulin degludec (IDeg) offer convenience that increases adherence significantly (Table 13-7). They also tend to have fewer adverse effects, which can simplify patients' regimens and improve control.3-7
Designing a Regimen
For most patients, designing an optimal insulin regimen is a continuing process that may require formulation changes, dose-related fine tuning, and intro Continue reading

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Cholesterol Drugs (Statins) Linked To Diabetes, Brain Damage & Much More

Cholesterol Drugs (Statins) Linked To Diabetes, Brain Damage & Much More

What’s the deal with Cholesterol? Good, bad, both, myth? Perhaps it is a myth, something that’s been made into a problem so pharmaceutical companies can keep raking in the cash? Statins alone generate billions of dollars a year. The important point to take note of is the fact that Statins, drugs designed to lower ones cholesterol, are one of the biggest drugs prescribed to patients, and one of the biggest earners for pharmaceutical companies, which is concerning.
Why is it concerning? Because over the years, it’s become more and more difficult for people to trust pharmaceutical companies for several different reasons. Whether it’s about studies that continue to expose the harmful effects of various drugs, or the chief editors of Major Medical journals like Dr. Richard Horton (editor in chief of the Lancet )”blowing the whistle,” so to speak, there is large . (1)(2)(3)(4)
Now, a new study recently published in the American Journal of Physiology, states that statins the adverse effects of statins advance the process of aging, and points out that long term use of stats have been associated with several serious adverse health effects including myopathy (skeletal muscle weakness), neurological side effects and an increased risk of diabetes.”
The study outlines the negative effect statins have on mesenchymal stem cells (MSCs), and how they also impaired the expression of DNA repair genes which, the authors believe, proved a “novel explanation for their adverse clinical effects.”
We know that that the ability of these cells to differentiate isn’t good, and stat Continue reading

Do You Know Your Insulin Level?

Do You Know Your Insulin Level?

People often keep close watch on their glucose numbers. But how many of us know our insulin level? Dr. Joseph Mercola says fasting insulin is “the number that may best predict your sudden death.” Sounds important. But what does it mean?
Our bodies need some circulating insulin at all times, even when we don’t eat. Otherwise, our livers keep making glucose and dumping it into the blood. Livers do this to prevent blood glucose from going too low.
So a fasting insulin level should never be 0, which it might be in a person with untreated Type 1. It shouldn’t go below 3. But a high insulin level is just as problematic. A high insulin level is a sign of insulin resistance or prediabetes. It can also signify early-stage Type 2.
According to Dr. Mercola, too much insulin promotes weight gain by storing fat. It promotes insulin resistance, lowers magnesium levels, and increases inflammation. It also tends to lower HDL (“good”) cholesterol and raise levels of LDL (“bad”) cholesterol.
All of these increase the risk of diabetes and heart disease. It may be that high insulin levels come before insulin resistance and help cause it.
If you already have diabetes, why should you know your insulin level? Mainly, it helps diagnose what is happening with you. Your blood glucose may be high, but how much of the problem is too little insulin? How much is insulin resistance?
A fasting insulin level test is valuable in several situations:
• Diagnosing prediabetes and metabolic syndrome. “Prediabetes” is one result of insulin resistance. Insulin resistance causes high choleste Continue reading

Diabetes-Friendly Drink Recommendations

Diabetes-Friendly Drink Recommendations

Food and eating can be a stressful thing when you have diabetes. If you're living with type 1, type 2 or gestational diabetes, meal times can be a cause of stress; but another source of worry is what to drink when you have diabetes. If you're controlling your diabetes and blood sugar by diet and exercise or with medications and insulin, you still need to be cautious of the food and drinks that enter your body.
Living with type 1 diabetes myself, I know first hand how much one wrong drink choice can affect my blood sugar levels. A type 1 diabetic does not produce insulin themselves so they must inject insulin with each meal. Making sure what you consume including drinks in between meals is important. In fact, drinking just one sweetened drink a day can raise your risk of type 2 diabetes by 25 percent.
People tend to think that fruit juice is a good choice, but with a high concentration of fructose, diabetics should only consume fruit in its whole form. When fruit is juiced it is stripped of all its fiber, and fiber is what helps to slow down the blood sugar spike. Consuming fruit juice will set you up for a roller coaster of blood sugar levels all day. Fruit juice should be reserved only when you're dealing with hypoglycemia - in this case you are drinking it to increase your already too low blood sugar.
Read more about foods that naturally lower blood sugar levels
Alcohol is another beverage that diabetics should be wary of. Alcohol is a contributing factor to hypoglycemia. You will first experience an increase in your blood sugar levels due to the sugar content, then a rea Continue reading

32 Home Remedies for Diabetes

32 Home Remedies for Diabetes

Even though it looks much the same as any other foot, the diabetic foot requires special attention. Why? Nerve damage is common with diabetes, especially in the lower extremities. Blood vessels are damaged as a result of the disease and circulation is decreased. When this happens, feet and legs tend to be cold and sores heal slowly, in some cases taking years to heal. This can easily lead to infection. Nerve damage can also decrease your ability to feel sensations in your feet, such as pain, heat, and cold. That means you may not notice a foot injury until you have a major infection.
A common complaint from many people is, "My feet are killing me!" For a person with diabetes, that statement could be all too true. Loss of nerve function, especially on the soles of the feet, can reduce feeling and mask a sore or injury on the foot that, if left unattended, can turn into an ulcer or gangrene.
Neuropathy, damage to the nerves, is a common problem for people with diabetes. It occurs most often in the feet and legs, and its signs include recurring burning, pain, or numbness. In addition to being painful, neuropathy can be harmful because if it causes a loss of feeling in the foot, even a minor foot injury may go undiscovered. In extreme cases, this can lead to serious infection, gangrene, or even amputation of the limb. Because of this, people with diabetes must be meticulous in caring for their feet.
Moderate exercise, such as walking, cycling, or swimming, are best for people with diabetes. Because people with diabetes have to take some extra precautions while exercising, you w Continue reading

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