JDRF Invests In TetraGenetics’ Innovative Approach To Type 1 Diabetes Prevention

JDRF Invests in TetraGenetics’ Innovative Approach to Type 1 Diabetes Prevention

JDRF Invests in TetraGenetics’ Innovative Approach to Type 1 Diabetes Prevention

A unique scientific approach to preventing, treating and, perhaps one day, curing type 1 diabetes is being coupled with JDRF’s equally innovative approach to funding such studies in a new partnership that might move the promise of a preventive therapy and improved treatment for the condition closer to reality.
“This is a very targeted therapeutic approach to addressing type 1 diabetes,” says Dr. Ted Clark, the Chief Scientific Officer for TetraGenetics, a company that has been working for the past several years on developing drugs to prevent and treat diabetes. “Our technology has the potential to effectively block the specific autoimmunity response that is responsible for causing the disease.”
JDRF believes in TetraGenetics’ innovations to the point they are putting their money and support behind the company and its approach to addressing a potential type 1 diabetes preventive therapy. It announced that one of the organization’s first investments from their new T1D Fund—a fund that specifically supports “high-impact early-stage investments to accelerate commercial development of life-changing therapies for people living with T1D”—will be made in TetraGenetics.
“We think the work they are doing could have a real impact,” says Dr. Jonathan Behr, the Managing Director of the T1D Fund. “Our belief is that this is a partnership that could show real results and change lives for the better.”
To fully understand the mechanizations of TetraGenetics’ technology and how it applies to type 1 diabetics you need to lean back to take a macro view of what c Continue reading

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An early signpost for type 1 diabetes?

An early signpost for type 1 diabetes?

Type 1 diabetes is one of the most common serious diseases to strike young children, but how does it start? It’s a question that has bedeviled scientists for years. Now, a new study pinpoints a warning sign in healthy babies as young as 6 months old. The work could advance prevention efforts and might help explain the genesis of the autoimmune disease.
Type 1 diabetes hits when the body destroys insulin-producing cells in the pancreas. By the time people—many of them children—are diagnosed, most of those cells are gone. Forty thousand new type 1 diabetes cases are recorded each year in the United States, and the disease is on the rise for reasons not well understood. A dream for diabetes researchers is to treat kids earlier, when they are headed down the diabetes road but aren’t yet there.
About 3 decades ago, scientists discovered a collection of signposts: antibodies directed at certain proteins in the body, including insulin. As they studied these children more intensively, they learned that those with two or more different kinds of these autoantibodies will eventually develop diabetes, though sometimes not for many years. Many clinical trials have since focused on trying to slow disease onset in these individuals.
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But what happens before these autoantibodies arise? Ezio Bonifacio, a biologist at the Technische Universität Dresden in Germany, had the means to tackle t Continue reading

Traveling through airport security with diabetes devices (with or without #OpenAPS)

Traveling through airport security with diabetes devices (with or without #OpenAPS)

tl;dr: Put your #OpenAPS or other artificial pancreas rigs through the x-ray machine; it’s a small computer and a battery.

I travel quite a bit these days, so it’s pretty routine for me to pack up my diabetes gear and backup supplies and whisk away to the airport and the next adventure. In fact, in 2016 I think I went through airport security 44+ times, in several countries. I have never had any issues with my #OpenAPS (DIY hybrid closed loop artificial pancreas) rigs – even when I carry multiples. Here are some tips on what gear should be put where, who should be told what during the security process, and how to further simplify (as much as is possible with diabetes!) the airport security experience when traveling with diabetes.
6 little pancreases went to the airport & had no problems in security, as usual. #OpenAPS #emergencybackuppancreases pic.twitter.com/eFfYru2Ivt
— Dana #hcsm #OpenAPS (@danamlewis) February 14, 2017
A list of diabetes gear you’re probably packing for your trip:
BG meter
Test strips
Pump sites
CGM sensors
CGM receiver
Tape for sites/sensors
Syringes as back up
Anti-nausea meds
Depending on the length of your trip, backup pump/transmitter/meter/receiver/etc.
Extra batteries to power your phone for uploading BGs
(Uploader phone if you’re still using an uploader to Nightscout)
Artificial pancreas rig (i.e. #OpenAPS rig, whether that’s a Raspberry Pi or Explorer Board setup, or a Rileylink)
Extra insulin
Juice for lows
Out of that list? Here are the only things I would pull out of your bag.
Insulin/ex Continue reading

How hibernating animals are helping doctors treat diabetes and Alzheimer's

How hibernating animals are helping doctors treat diabetes and Alzheimer's

People go to sleep, their bodies cool down, and their skin turns blue, as electronic monitors show the heart rate and respiration plummeting almost to nothing. That’s the kind of dramatic image of human hibernation we see in science fiction. Usually, the premise is that characters must spend long time periods travelling through outer space without dying of old age, or writers and futurists have imagined such a capability applied to patients with terminal diseases, so they can be revived when cures have been developed centuries later.
Real-life research into human hibernation, often called suspended animation, may eventually transform those sci-fi images into science fact, but in the near-term, hibernation is poised to transform medicine.
Physicians today already employ mild therapeutic hypothermia - they lower core body temperature of patients by a few degrees - to slow metabolism, routinely after cardiac arrest. It’s also routine to cool patients to facilitate certain operations, such as open-heart procedures, including valve replacement and coronary artery bypass surgery (CABG). Less frequently, doctors lower body temperature by more than a few degrees and clinical trials are underway to stall death for a couple of hours by lowering body temperature to just a few degrees above freezing in victims of severe blood loss trauma.
The latter scenario amounts to short-term, but real-life, suspended animation. While therapeutic hypothermia is standard in hospitals, scientists are trying to steal tricks from hibernating animals, such as ground squirrels.
“Thermoregulatory re Continue reading


County-Level "Diabetes Belt" Carves a Swath through U.S. South

More than 18 million people in the U.S. have been diagnosed with diabetes, which costs an estimated $174 billion annually. Typically, local public health agencies carry out the initiatives to manage and prevent this chronic disease, but because prevalence figures are generally given on national and state levels, local workers cannot gain the traction—and funding—to rein in rates in their areas.
A new study drills down to the county level, revealing wide disparities within states and striking national patterns. "We're extremely excited about the county level," says Lawrence Barker, associate director for science at the U.S. Centers for Disease Control and Prevention (CDC) Division of Diabetes Translation.
Many of the counties with the highest rates of diagnosed diabetes—higher than 11.2 percent of the population compared with the national average of 8.5 percent—are concentrated in 15 states and form an area the study's authors have labeled the "diabetes belt" (after the so-called "stroke belt" that described U.S. Southeast in the 1960s).
"We've known for many years that there was a lot of diabetes in the Southeast," Barker says. But the new analysis, based on data from the self-reported national phone survey called the Behavioral Risk Factor Surveillance System (BRFSS), confirmed that the disease has a distinctive geographical distribution. The map and findings will be published in the April 2011 issue of the American Journal of Preventive Medicine.
The pattern of disease distribution is not a simple slice—nor does it follow the stroke belt. The diabetes belt touch Continue reading

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