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Improving Drugs For Type 2 Diabetes

Improving drugs for type 2 diabetes

Improving drugs for type 2 diabetes


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Scientists are exploring a central component in glucose regulation. Their findings shed new light on the structure of the glucagon receptor, a highly promising target for diabetes drug development.
Beam me up: The new Nature study reports the crystal structure of the full-length human glucagon receptor (GCGR) that plays a key role in glucose homeostasis and serves as an important drug target for Type 2 diabetes. X-ray crystallography yields the complete, detailed, architecture of this class B membrane protein receptor for the first time, dramatically improving the prospects for a new generation of highly specific drugs for treating Type 2 diabetes with greater effectiveness and fewer side effects.
Credit: Graphic by Jason Drees for the Biodesign Institute
Beam me up: The new Nature study reports the crystal structure of the full-length human glucagon receptor (GCGR) that plays a key role in glucose homeostasis and serves as an important drug target for Type 2 diabetes. X-ray crystallography yields the complete, detailed, architecture of this class B membrane protein receptor for the first time, dramatically improving the prospects for a new generation of highly specific drugs for treating Type 2 diabetes with greater effectiveness and fewer side effects.
Credit: Graphic by Jason Drees for the Biodesign Institute
Type 2 diabetes, a prolific killer, is on a steep ascent. According to the World Health Organization, the incidence of the condition has grown dramatically from 108 million cases i Continue reading

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Jennifer Stone And 6 Other Celebrities Who Have Type 1 Diabetes

Jennifer Stone And 6 Other Celebrities Who Have Type 1 Diabetes


Jennifer Stone And 6 Other Celebrities Who Have Type 1 Diabetes
The start of November also marks the start of National Diabetes Awareness Month and stars living with the condition are usingthis as the perfect time to speak up.
On Wednesday, Disney Channel alum Jennifer Stone revealed that she as diagnosed with Type 1 Diabetes in 2013 and thats taken her a while, but shes finally ready to talk about it with the world.
It has been a long road to get to a place where I was comfortable telling you guys about my Type 1, Stone captioned her Instagram post revealing the diagnosis. Today I am finally ready to fill you in on my journey and help others with diabetes feel less alone in this. I want to make the world a better place for those with diabetes and I cant do that by staying quiet!
A post shared by Jennifer Stone (@jenniferstone) on
By sharing her story, Stone joins a list of other celebrities with Type 1 Diabetes who are using their voices to raise awareness.
Here are six other stars living with the condition:
The singer was diagnosed with Type 1 in 2005, but it wasnt until 2007 until he shared the information with his fans. After the news was out, Jonas began to speak openly about the condition and his journey with it.
In 2008, he released a song as part of the Jonas Brothers called A Little Bit Longer, which detailed his feelings about living with Type 1 Diabetes. Hescontinued to be an advocate for the cause in the 10 years since he made his original announcement.
For anyone living with diabetes.. Or any disease that complicates your life in any way.. Just know Continue reading

Type 1 Diabetes  Naturopathic Doctor News and Review

Type 1 Diabetes Naturopathic Doctor News and Review


The worldwide statistics regarding diabetes are frightening. In 2011, 366 million people around the world were diagnosed with diabetes, and it is projected that, by 2030, up to 552 million people will have itnearly 10% of the worlds adult population. In the US, there are 29 million people with diabetes, and approximately 1.25 million have type 1 diabetes mellitus (T1DM), including 1 out of every 300 children. In fact, the most recent US data indicates the occurrence of T1DM increased by 21% between 2001 and 2009.
Worldwide, there are 70,000 new cases annually, and T1DM occurrence is rising by an estimated 3% each year. Around 24% of T1DM pediatric patients live in European countries; 23% are in Southeast Asia, and 19% are in North America and the Caribbean. Unfortunately, in Sub-Saharan countries where insulin may be difficult to get and use, there is a high mortality rate of 42.6 deaths per 100,000, while in the US, there are only 0.63 deaths per 100,000.1
Aside from pediatric-onset T1DM, adult-onset T1DM is also growing. Known as latent autoimmune diabetes of the adult, or LADA, this type of T1DM is still commonly mistaken for type 2 diabetes. Occurring in patients generally over 35 years old, around 4-14% of patients diagnosed with T2DM have diabetes-associated antibodies or LADA.2
What is driving the increasing incidence of T1DM? There are many factors that are being studied.
There are multiple HLA genes associated with turning on the auto-immune activity directed against the pancreatic beta cells, leading to the lack of insulin secretion that is the keynote chara Continue reading

Playing for Syracuse, Andrew Armstrong keeps a positive view on type 1 diabetes

Playing for Syracuse, Andrew Armstrong keeps a positive view on type 1 diabetes


Playing for Syracuse, Andrew Armstrong keeps a positive view on type 1 diabetes
As many as 3 million adults in the United States have type 1 diabetes, and about 30,000 more individuals are diagnosed with the disease each year . In 1999, I became part of that statistic at 11 years old, and have dealt with it for the 18 years since. Syracuse Orange linebacker Andrew Armstrong received his own diagnosis a lot more recently in life, as a senior at Cardinal Mooney High School.
Everyone deals with diseases -- type 1 or otherwise -- on their own terms. And for me, its only recently been something I discuss openly. However, Andrew was more than willing to take the time to discuss how he deals with type 1. He and I spoke on the phone after Thursday mornings practice.
I was actually diagnosed my senior year of high school, in November, he said. I played my junior year of football prior to being diagnosed. I felt real sluggish throughout the season, had frequent urination, mood swings, I wasnt eating or drinking a ton -- I just didnt feel right.
So when my parents brought me to the doctor and they ran some tests and my blood sugar was in the 400s. They rushed me to the emergency room, and there they diagnosed me with Type 1.
For people with working pancreas, blood sugar levels typically range from 70 or so up to 120/130. Their body produces insulin to help break down sugar in the bloodstream, regulating that number to stay within a certain range at all times. If a non-diabetic eats a lot of sugar, their body balances that out with insulin. And if theyre very active or havent ea Continue reading

Chiropractors and Diabetes Gimmickry

Chiropractors and Diabetes Gimmickry


Skeptic Authors Steven Salzberg and Joe Nickell to Receive Balles Prize in Critical Thinking
Forbes columnist Steven Salzberg and author-investigator Joe Nickell will each be awarded the 2012 Robert P. Balles Prize in Critical Thinking, to be presented by the Committee for Skeptical Inquiry at the CFI Summit in October.
The more I study the activities of chiropractors, the more I find myself comparing them to striptease dancing as depicted in my favorite humorous musical number from the 1962 movie Gypsy.
The scene is a dressing room in a burlesque theater in Wichita, Kansas. Louise Hovick (who eventually becomes striptease star Gypsy Rose Lee) is a young woman with a booking at the theater to sing and dancebut not strip. She encounters three seasoned strippers. She explains to them that she doesnt have any talent for stripping.
One of the strippers, Miss Mazeppa, assures her: To be a stripper, all you need to have is no talent.
Another stripper, Tessie Tura, counters: Pardon me! But to have no talent is not enough. What you need to have is an idea that makes you strip special!
And so begins a performance of You Gotta Have a Gimmick.
Miss Mazeppas gimmick is to do it with a horn, which she proceeds to blow. Tessie Turas gimmick is to do it with ballet dancing. Miss Electras gimmick is to do it with a costume lit up like a Christmas tree.
Chiropractors also have gimmicks. I see their gimmicks as much more seductive than the gimmicks of strippers in Gypsy.
Chiropractics identity as a profession depends on a gimmick: promoting the implausible notion that chiropractor Continue reading

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