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Impact Of Metformin On Cardiovascular Disease: A Meta-analysis Of Randomised Trials Among People With Type 2 Diabetes

Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes

Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes


, Volume 60, Issue9 , pp 16201629 | Cite as
Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes
Metformin is the most-prescribed oral medication to lower blood glucose worldwide. Yet previous systematic reviews have raised doubts about its effectiveness in reducing risk of cardiovascular disease, the most costly complication of type 2 diabetes. We aimed to systematically identify and pool randomised trials reporting cardiovascular outcomes in which the effect of metformin was isolated through comparison to diet, lifestyle or placebo.
We performed an electronic literature search of MEDLINE, EMBASE and the Cochrane Library. We also manually screened the reference lists of previous meta-analyses of trials of metformin identified through a MEDLINE search. We included randomised controlled trials of adults with type 2 diabetes comparing any dose and preparation of oral metformin with no intervention, placebo or a lifestyle intervention and reporting mortality or a cardiovascular outcome.
We included ten articles reporting 13 trials (including a total of 2079 individuals with type 2 diabetes allocated to metformin and a similar number to comparison groups) of which only four compared metformin with placebo and collected data on cardiovascular outcomes. Participants were mainly white, aged 65years, overweight/obese and with poor glycaemic control. Summary estimates were based on a small number of events: 416 myocardial infarctions/ischaemic heart disease events in seven studies and 111 strokes in four studies. Continue reading

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Homemade Korean Kimchi Recipe – Fights Diabetes and Burns Fat in a Healthy Way

Homemade Korean Kimchi Recipe – Fights Diabetes and Burns Fat in a Healthy Way

What is Kimchi you might ask? Well, it is a traditional Korean dish made from fermented cabbage and various spices, plus salt and vinegar. It has recently gained more popularity and you can easily find it in most healthy food stores nearly everywhere. But like with most healthy alternatives, it is even better to make your own homemade Korean kimchi recipe.
So, here you’ll learn the incredible benefits of kimchi as well as the recipe to prepare it at home.
Homemade Korean Kimchi Benefits!
In order to better explain the Korean Kimchi Recipe, it is the process of fermentation which cultivates this natural source of probiotics. That’s how healthy bacteria is born, which also improves the taste.
The bacteria in question, Lactobacillus, plays a crucial part in a healthy digestive system and intestines. Many already recognize cabbage as a soother for inflammation, as well as its detoxification abilities.
But by fermenting it, we make it even healthier by complementing it with even more nutrients and making it bioavailable. In this way, it can also aid in preventing ulcers, obesity, diabetes and even some types of cancer!
Kimchi is a must-have in the Korean cuisine, and the whole world should take a page from their book in this matter. So here is a whole bunch of information on the health benefits of this particular fermented food.
Once you read through them and get informed, you might also want to try the following recipe in the comfort of your home.
It will Improve your Gut Health
You may know cabbage as the gut’s benefactor, but consuming it in its fermented form can help Continue reading

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial

OBJECTIVE The Diabetes Control and Complications Trial (DCCT) demonstrated the beneficial effects of intensive versus conventional therapy on the development and progression of microvascular complications of type 1 diabetes. These beneficial effects were almost completely explained by the difference between groups in the levels of HbA1c, which in turn were associated with the risk of these complications. We assessed the association of glucose variability within and between quarterly 7-point glucose profiles with the development and progression of retinopathy, nephropathy, and cardiovascular autonomic neuropathy during the DCCT.
RESEARCH DESIGN AND METHODS Measures of variability included the within-day and updated mean (over time) of the SD, mean amplitude of glycemic excursions (MAGE), and M-value, and the longitudinal within-day, between-day, and total variances. Imputation methods filled in the 16.3% of expected glucose values that were missing.
RESULTS Cox proportional hazards models assessed the association of each measure of glycemic variation, as a time-dependent covariate, with the risk of retinopathy and nephropathy, and a longitudinal logistic regression model did likewise for cardiovascular autonomic neuropathy. Adjusted for mean blood glucose, no measure of within-day variability was associated with any outcome. Only the longitudinal mean M-value (over time) was significantly associated with microalbuminuria when adjusted for the longitudinal mean blood glucose and corrected for multiple tests using the Holm procedure.
CONCLUSIONS Overall, within-day glycemic va Continue reading

HEALTH: Managing Diabetes in Pro Wrestling

HEALTH: Managing Diabetes in Pro Wrestling

According to the American Diabetes Association, in 2012, 29.1 million Americans had diabetes. 1.4 million Americans are diagnosed every year.
Also according to the American Diabetes Association, diabetes was the 7th leading cause of death in the U.S. in 2010.
There is a stereotype that everybody in professional wrestling is so jacked-up and healthy that they couldn’t possibly have health issues. This stereotype, like many others, is false.
Those in the professional wrestling industry are not immune to diseases such as diabetes. In fact, in this article we will take a look at three individual cases of personalities in the industry battling diabetes.
Jesse Hernandez, Jacob Tarasso, and myself have all been diagnosed with diabetes. Hernandez is a retired pro wrestler and referee, turned promoter (Empire Wrestling Federation). Jacob Tarasso is an active professional wrestler. I am a play by play commentator.
Hernandez was diagnosed with Type-II Diabetes in 1992 when he went in for a drivers license for a city job. Tarasso’s diagnosis came at age 15 when lab results showed sugar in his urine. My diagnosis was in July 2010 after lab tests.
Symptoms that I was told to look out for were frequent thirst, increased fatigue, and blurred vision.
» CHECK YOUR BLOOD SUGAR
Make sure to check your blood sugar levels so you know how to plan accordingly, and take appropriate steps in either bringing up levels or bringing them down.
Tarasso now has a portable meter to check his blood sugar, at which he checks it before breakfast and dinner.
“I check my levels everyday before breakfast, Continue reading

diabetes mellitus in children

diabetes mellitus in children

1. Duhok Pediatrics Diabetes center
2. Definition • It’s a chronic metabolic disorder characterized by hyperglycemia as a cardinal biochemical feature, caused by deficiency of insulin or its action, manifested by abnormal metabolism of carbohydrates, protein and fat
3. Epidemiology • Peaks of presentation occur in 2 age groups: at 5-7 yr of age (infectious) and at the time of puberty (gonadal steroids ). • Girls and boys are almost equally affected • There is no apparent correlation with socioeconomic status.
4. Incidence rates of type 1 diabetes mellitus by region and country
5. Diagnosis of diabetes is made when: • Symptoms + • random BGL ≥ 11.1 mmol/L (≥200 mg/dl) (or) • Fasting BGL ≥ 7mmol/L (≥ 126 mg/dl)
6. ETIOLOGIC CLASSIFICATIONS OF DIABETES MELLITUS Type I diabetes: (β-cell destruction, usually leading to absolute insulin deficiency) -Immune mediated. -Idiopathic. Type 2 diabetes: (may range from predominantly insulin resistance with relative insulin deficiency to a predominantly secretory defect with insulin resistance). Other specific types : Genetic defects of β-cell function:Chromosome 7, glucokinase (MODY2) Genetic defects in insulin action:Rabson-Mendenhall syndrome Diseases of the exocrine pancreas: Pancreatitis Endocrinopathies: Cushing disease Drug- or chemical-induced : Glucocorticoids Infections:Cytomegalovirus Uncommon forms of immune-mediated diabetes :Stiff-man” syndrome Other genetic syndromes sometimes associated with diabetes :Down syndrome Gestational diabetes mellitus Neonatal diabetes mellitus
7. Physiology • The ma Continue reading

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