Imbalance Of Gut Bacteria Linked To Elevated Risk For Diabetes
New data from researchers at the University of Copenhagen provides stronger evidence linking certain bacteria that populate our intestinal tract with a higher risk for developing insulin resistance, ultimately a precursor to developing diabetes.
The research was published in the journal Nature late last week, suggesting that the gut microbiome might be a potential target for therapeutic intervention in this ravaging disease.
Insulin resistance is a condition whereby the body still produces insulin, but is not able to utilize it effectively. When someone develops insulin resistance, glucose accumulates in the bloodstream rather than being absorbed by the cells in the body, ultimately leading to prediabetes or to type 2 diabetes.
After extensively studying a population’s gut microbial composition to identify specific compounds (branched-chain amino acids, BCAA) that ultimately led to insulin resistance from the action of specific bacteria, the researchers then extracted the causative bacteria and fed them to mice who were devoid of any bacterial flora (sham mice) to prove that the action of the bacteria on the gut flora was truly the cause of insulin resistance.
" We show that specific imbalances in the gut microbiota are essential contributors to insulin resistance , a forerunner state of widespread disorders like type 2 diabetes, hypertension and atherosclerotic cardiovascular diseases, which are in epidemic growth," said Professor Oluf Pedersen, Metabolism Center, University of Copenhagen, and senior lead author of the research.
The researchers from the University of Cop Continue reading