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Identification Of Novel Biomarkers To Monitor β-cell Function And Enable Early Detection Of Type 2 Diabetes Risk

Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk

Identification of novel biomarkers to monitor β-cell function and enable early detection of type 2 diabetes risk

Abstract
A decline in β-cell function is a prerequisite for the development of type 2 diabetes, yet the level of β-cell function in individuals at risk of the condition is rarely measured. This is due, in part, to the fact that current methods for assessing β-cell function are inaccurate, prone to error, labor-intensive, or affected by glucose-lowering therapy. The aim of the current study was to identify novel circulating biomarkers to monitor β-cell function and to identify individuals at high risk of developing β-cell dysfunction. In a nested case-control study from the Relationship between Insulin Sensitivity and Cardiovascular disease (RISC) cohort (n = 1157), proteomics and miRNA profiling were performed on fasting plasma samples from 43 individuals who progressed to impaired glucose tolerance (IGT) and 43 controls who maintained normal glucose tolerance (NGT) over three years. Groups were matched at baseline for age, gender, body mass index (BMI), insulin sensitivity (euglycemic clamp) and β-cell glucose sensitivity (mathematical modeling). Proteomic profiling was performed using the SomaLogic platform (Colorado, USA); miRNA expression was performed using a modified RT-PCR protocol (Regulus Therapeutics, California, USA). Results showed differentially expressed proteins and miRNAs including some with known links to type 2 diabetes, such as adiponectin, but also novel biomarkers and pathways. In cross sectional analysis at year 3, the top differentially expressed biomarkers in people with IGT/ reduced β-cell glucose sensitivity were adiponectin, alpha1-antitryp Continue reading

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How to make informed decisions from diabetes commercials

How to make informed decisions from diabetes commercials


How to make informed decisions from diabetes commercials
Reviewed by Natalie Olsen, RD, LD, ACSM EP-C
Memorable diabetes television commercials are often shared widely online. Staying informed about the topics they cover, and understanding key things to look out for, may help people make positive choices about how they manage their condition.
Many people have seen the diabetes commercial where Wilford Brimley, an actor with diabetes , pronounces diabetes in an unusual way.
The commercial has been parodied multiple times, which can lead to misinformation about what it is trying to say. However, it may be a useful source of information for people with diabetes.
This article explores what qualities good diabetes commercials should have. It also gives examples of some of the best adverts for people with diabetes.
The discussion that follows highlights things that people with diabetes should look out for in diabetes commercials. This is to help ensure they have the right information to make the best decisions about what they choose to buy.
Diabetes commercials must be emotive and memorable if the viewer is expected to engage with the product or service.
From a business standpoint, a good commercial needs to have an impact on the audience. It needs to inform the audience about the product or service it wants them to engage with.
From the viewer's perspective, a good diabetes commercial will be:
One of the best ways that commercials for diabetes spread awareness is through the use of celebrity endorsements.
Letting a celebrity with diabetes explain a product helps the Continue reading

Diabetes App Designed to Predict Blood Sugar Levels After Each Meal

Diabetes App Designed to Predict Blood Sugar Levels After Each Meal

For individuals with type 2 diabetes, managing glucose levels can be a daily challenge.
However, the introduction of a new algorithm-based app may soon take some of this stress away.
A lot of work still needs to be done on the process, but the idea behind the personalized technology is to predict the impact of each meal on a user’s blood sugar levels.
Type 2 diabetes now affects more than 29 million people in the United States. An additional 86 million adults are thought to have prediabetes, which can develop into type 2 diabetes if lifestyle changes are not implemented.
With type 2 diabetes comes a constant need to monitor food intake to ensure the correct blood glucose levels are maintained.
If levels are too high for prolonged periods of time, serious health complications can arise.
Medication is given to help manage sugar level fluctuations, but exercise and diet also play a substantial role.
Although the impact of specific food types on glucose levels can be estimated, it is not an exact science.
Effects can vary substantially between individuals and they can even vary within an individual dependent on a range of factors.
A report, published in PLOS Computational Biology this week, explains how a group of scientists have integrated an algorithm into an app called Glucoracle, which goes some way toward solving this problem.
David Albers, Ph.D., associate research scientist in biomedical informatics at Columbia University Medical Center (CUMC) in New York and lead author of the study, explains: “Even with expert guidance, it's difficult for people to understand the t Continue reading

Is it Safe to Take Turmeric with Diabetes Medicines?

Is it Safe to Take Turmeric with Diabetes Medicines?


Is it Safe to Take Turmeric with Diabetes Medicines?
YES, turmeric in the diet is perfectly safe to consume along with diabetes medications. However, turmeric supplements should be taken with care and at a gap of about 3-4 hours with diabetes medicines.
Curcumin, an active ingredient of turmeric assists in treatment, management and prevention of diabetes.
Studies have shown that curcumin, when taken with diabetes drugs has no adverse interactions. On the contrary, it gives better results and can inhibit the side effects of these medicines.
Care should be taken when taking turmeric with the medicines, as high dosage could lower blood glucose and result in hypoglycemia.
Let us take a look at what scientists have to say about these effects.
Curcumin found in turmeric can lower blood glucose levels and insulin resistance. It can also enhance the functioning of pancreatic cells which produce insulin. [ 1 ] [ 2 ]
The working mechanism of turmeric and anti-diabetic medicines is quite similar.
Curcuminoids and metformin, both target the AMP-activated protein kinase pathway which results in lowered blood glucose levels. [ 3 ] [ 4 ]
Curcumin improves insulin sensitivity and lipid parameters by inhibiting Tumor Necrosis Factor-alpha (TNF-) and reducing plasma free fatty acids. The drug rosiglitazone works in the same manner [ 5 ]
It assists in regulation of lipid levels, blood pressure and body weight, which decreases the risk of developing diabetes. [ 6 ] [ 7 ] [ 8 ]
Turmeric is also beneficial in the prevention and treatment of several other health complications which o Continue reading

Weight Watchers Jumps Eight Spots To #3 Best Diabetes Diet And Retains Top Spot As Best Fast Weight Loss Diet In 2018 Best Diets Report

Weight Watchers Jumps Eight Spots To #3 Best Diabetes Diet And Retains Top Spot As Best Fast Weight Loss Diet In 2018 Best Diets Report


Weight Watchers Jumps Eight Spots To #3 "Best Diabetes Diet" And Retains Top Spot As "Best Fast Weight Loss Diet" In 2018 Best Diets Report
Annual Rankings Released Today by U.S. News & World Report Indicate Weight Watchers is One of the Best Plans Available
NEW YORK, Jan. 3, 2018 /PRNewswire/ --Weight Watchers International, Inc. (NYSE: WTW ) has been recognized once again by health experts in the 2018 Best Diets rankings released today by U.S. News & World Report, which includes advancing to #3 for "Best Diabetes Diet" (up from #11 in 2017). The "Best Diabetes Diets" ranking evaluates plans based on their ability to both prevent and manage the disease. Recent research has demonstrated the benefits of Weight Watchers programs for both prediabetes and diabetes. Specifically, clinical trial participants showed significant reductions in both weight and blood sugar control1,2,3.
Weight Watchers also received top recognition in six additional categories:
Ranked #1 for "Best Fast Weight-Loss Diet" for the second consecutive year since the category was added in 2016
Ranked #1 for "Best Weight-Loss Diet" for the eighth consecutive year
Ranked #1 for "Best Commercial Diet Plan" for the eighth consecutive year
Ranked #5 for "Best Diet for Healthy Living"
"For nearly 55 years, Weight Watchers has been known for taking the latest science and making it actionable and livable for our members. We are leaders because our science-based, proven program consistently inspires healthy habits for real life," said Gary Foster, PhD, Chief Scientific Officer, Weight Watchers Internationa Continue reading

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