How type 2 diabetes can be reversed with a low-calorie diet
Recently, the idea that type 2 diabetes might be reversible has been gaining traction in the research community. But until now, the mechanisms driving this remission have not been known. A new study sheds light.
Earlier this year, Medical News Today reported on a paper published in the BMJ that urged doctors and patients alike to acknowledge the possibility that type 2 diabetes is reversible through weight loss.
Another study we reported on showed that caloric restriction helped 40 percent of the participants in the study to achieve remission. And now, researchers unravel the mechanism by which caloric restriction leads to the reversal of this chronic condition in rats.
The team was led by senior investigator Dr. Gerald I. Shulman, the George R. Cowgill Professor of Medicine and Cellular and Molecular Physiology at Yale University in New Haven, CT, and the first author of the paper is Dr. Rachel J. Perry, from the Department of Internal Medicine at Yale's School of Medicine.
Dr. Perry and her colleagues investigated how 3 days on a very low-calorie diet (VLCD) reversed type 2 diabetes markers in the rodents, and the findings were published in the journal Cell Metabolism.
Speaking to MNT about the motivation for her research, Dr. Perry said, "We became interested in this work because [type 2 diabetes] is increasingly being considered a surgical disease."
"[B]ariatric surgeons are able to generate a rapid reduction in plasma glucose concentrations within days of weight loss surgery, such that patients are often able to leave the hospital off all their diabetes drugs," she add Continue reading