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How Pancreatic Tumors Could Help To Fight Diabetes

How pancreatic tumors could help to fight diabetes

How pancreatic tumors could help to fight diabetes


How pancreatic tumors could help to fight diabetes
New research may change how we think about treatment options for diabetes.
A new study analyzes rare tumorsin which insulin-producing beta cells are produced in excess in order to find a "genetic recipe" for regenerating these cells. And thefindingsmight change the current therapeutic practices for treating diabetes.
Beta cells play a crucial role in the development of diabetes . These tiny cells found in our pancreas produce insulin , and a loss of beta cells is known to be a cause of type 1 diabetes .
Additionally, recent studies have shown that beta cells also play a crucial role in the development of type 2 diabetes . For instance, a study thatMedical News Today reported on found that the release of pro-inflammatory proteins kills off insulin-producing beta cells in the early stages of type 2 diabetes.
But the "problem" with beta cells, medically speaking, is that they replicate in early childhood but cease to proliferate after that.
New research, however, carried out by scientists at the Icahn School of Medicine at Mount Sinai in New York City, NY, uncovers a "genomic recipe" for regenerating these key cells.
The study was led by Dr. Andrew Stewart, the director of the Diabetes, Obesity, and Metabolism Institute at the Icahn School of Medicine, and the findings were published in the journal Nature Communications.
For the new research, Dr. Stewart and team analyzed a very rare type of benign tumor called insulinomas. These are "pancreatic beta cell adenomas" that secrete too much of the hormone insulin.
The t Continue reading

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Gestational diabetes: 'I was misdiagnosed by my doctor' - Kidspot

Gestational diabetes: 'I was misdiagnosed by my doctor' - Kidspot


On the day I was booked in for my three-hour glucose tolerance test I woke feeling like death. Already two and a half weeks into battling a severe flu you know the pee-yourself-coughing kind juggling a toddler and severe sleep deprivation due to the constant coughing and blocked sinuses, I knew I was about to endure the longest three hours of my life. With the drink down the hatch, and only the first of three blood samples taken, I already had the sense all was not right. I was far more affected physically than the last time and needed to lie down immediately to keep me from fainting.
I managed to keep the drink down and had blood drawn two more times. I left relieved it was over, but instinctively knowing this was not the end of the saga.
The following Monday, I receive a call from my obstetricians office. I am on the set of a photoshoot and busy instructing the photographer where to set up, briefing the hair and makeup artist and getting the looks I will style on the model ready. I answer my phone and its the obstetricians secretary. We exchange hellos and then she says, you have gestational diabetes.
I am completely taken by surprise, and was left speechless as she tells me she is booking me in to see an endocrinologist ASAP and they will be in touch to let me know about the diet I need to start on straight away and the apparatus I will need to buy to test my blood daily at multiple times. We hang up and I stand shell-shocked, tears flow as I ring my husband and tell him the news.
Then I think about it, I was so sick the day I had the test, could that have skewed Continue reading

Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment

Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment


Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment
Peptide Immunotherapy for Type 1 Diabetes: A Promising New Treatment
Peptide immunotherapy offers a more nuanced approach that may reduce the risk for adverse effects in persons with type 1 diabetes.
Type 1 diabetes is characterized by the autoimmune destruction of pancreatic beta cells, leading to progressively decreasing insulin secretion. As beta cells die, hyperglycemia becomes more persistent, and most persons with type 1 diabetes have chronic hyperglycemia and often suffer from complications such as nephropathy and retinopathy. At present, treatment for type 1 diabetes targets hyperglycemia, but does not affect the underlying autoimmune processes.1
Immunomodulatory treatment, or immunotherapy, seeks to influence the immunological pathways that mediate beta cell destruction.1 "In the field of type 1 diabetes, we've been actively searching for ways to induce disease remission so that we can limit beta cell death, preserve endogenous insulin secretion, and limit the need for insulin injections," Carmella Evans-Molina, MD, PhD, from the Center for Diabetes and Metabolic Diseases at Indiana University in Indianapolis, told Endocrinology Advisor.
Although more than 25 years has been spent investigating immunotherapy for type 1 diabetes, no agent has proven to be effective at inducing remission in type 1 diabetes with an acceptable safety profile. Advances in the understanding of autoimmune conditions have led to the development of antigen-specific immunotherapy (ASI) and a subset of ASI known as pep Continue reading

GMOs Have Helped Fight Diabetes and Other Interesting Facts

GMOs Have Helped Fight Diabetes and Other Interesting Facts


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GMOs Have Helped Fight Diabetes and Other Interesting Facts
What are some interesting examples of GMOs (Genetically Modified Organisms)? originally appeared on Quora : the place to gain and share knowledge, empowering people to learn from others and better understand the world.
Answer by Janice Person , worked with & eaten GMO crops since 1996, currently works at Monsanto, on Quora :
With the buzz around genetically modified organisms over the past few years, it seems that not everyone knows about the most interesting GMOs. I have quite a few that I enjoy talking about and I frequently hear people ask why they havent heard of them before. So, Im going to walk through some of my favorites that are the type of genetically engineered products that most people mean when they say GMO.
INSULIN Few folks think about GMOs in the full set that science does, but insulin is considered the first GMO, before that it was sourced from taking the pancreas from animals [1] .Having had a diabetic or two in my extended family, the ability to produce insulin faster and easier, is something really rewarding and I frequently wonder how awesome it would feel to have been on that breakthrough team to develop something that proves to be lifesaving for others.
IN A NUTSHELL My favorite GMO is probably the American chestnut tree that the State University of New York College of Environmental Science and Forrestry has been working on. I grewup in a part Continue reading

New research links outdoor air temperature and risk of developing gestational diabetes

New research links outdoor air temperature and risk of developing gestational diabetes

TORONTO, May 15, 2017 - Women who were exposed to colder temperatures during pregnancy had a lower rate of gestational diabetes than those exposed to hotter temperatures, according to a study published online today in the Canadian Medical Association Journal.
The prevalence of gestational diabetes was 4.6 per cent among women exposed to extremely cold average temperatures (equal to or below -10 C) in the 30-day period prior to being screened for gestational diabetes, and increased to 7.7 per cent among those exposed to hot average temperatures (above 24 C). The study also found that for every 10-degree Celsius rise in temperature, women were six to nine per cent more likely to develop gestational diabetes.
The study examined 555,911 births among 396,828 women over a 12-year period. All the women studied lived in the Greater Toronto Area, but some were pregnant when the average temperature was warmer, and some when it was cooler.
Researchers looked at the relationship between the average 30-day air temperature prior to the time of gestational diabetes screening in the second trimester, and the likelihood of gestational diabetes diagnosis.
Dr. Gillian Booth, a researcher at St. Michael's and the Institute for Clinical Evaluative Sciences (ICES) and lead author of the study, said the finding might seem counterintuitive, but can be explained by emerging science about how humans make different kinds of fat.
"Many would think that in warmer temperatures, women are outside and more active, which would help limit the weight gain in pregnancy that predisposes a woman to gestational Continue reading

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