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Finnish Diabetes Vaccine Trials To Start In 2018

Finnish diabetes vaccine trials to start in 2018

Finnish diabetes vaccine trials to start in 2018

A vaccine for type 1 diabetes developed by Finnish researchers will be tested on mainly Finnish human subjects in late 2018, researchers announced on Tuesday.
The scientists first found that the prototype works effectively and safely on mice, and now say
that the vaccine could be in mainstream use within eight years if the coming rounds of tests prove successful.
The vaccine will first be given to a group of 30 healthy men during the first phase of the clinical trials, followed by a group of some 150 children if all goes well. After two successful rounds the vaccine can be considered safe and effective against viruses. The final round of vaccinations, intended for a group of some 4,000 children, should tell researchers whether the vaccine specifically prevents type 1 diabetes.
Virus likely culprit
A virus may be behind a significant proportion of type 1 diabetes cases, which are especially common among children. Professor Heikki Hyöty from the University of Tampere and Professor Mikael Knip of the University of Helsinki have worked on the pathology of diabetes from more than 20 years, and say they are confident that an enterovirus that attacks the pancreas to destroy insulin-producing cells is the root cause of type 1 diabetes.
If the vaccine proves effective in humans, it could do much to minimise suffering as well as expenses.
"It is estimated that the additional cost of care for one child with diabetes over their lifetime is about a million euros," Knip says. "This vaccine could prevent at least half of new cases, which amounts to some 250 million euros in annual saving Continue reading

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Charity says diabetes patients in NI denied equipment

Charity says diabetes patients in NI denied equipment

Diabetes patients in Northern Ireland are being denied access to essential equipment which would help control their condition.
Three years ago, the department of health bought more than 1,000 insulin pumps costing over £2m.
However, according to the local director for Diabetes UK, more than half of the pumps remain in "hospital cupboards".
Iain Foster said it was a "public scandal" and a waste of money.
"This has happened because individual health trusts have not created modern diabetes services which would ensure these pumps are issued to the people who would benefit from them," he said.
"This is evidence of how disjointed our health service is."
A diabetes specialist nurse said providing the automatic pumps was in line with national health care guidance.
At a recent seminar in Belfast, Sally Friffina said there was a need for the NHS to make more of this therapy option for adults in Northern Ireland.
"Proper care and modern treatment and technology can and does make a real difference to adults with Type 1 diabetes. The NHS and the government need to work towards making the treatment and technology available to all those Type 1 patients in line with the health care guidance. "
More than 80,000 people in Northern Ireland live with the illness.
In a statement to the BBC, the Department of Health spokesperson said : "NICE Technology Appraisal No 151 about the provision of insulin pumps, endorsed by DHSSPS in June 2009, applies to all HSC Trusts and significant progress has been made to implement it.
"Trusts now provide insulin pumps to about 611 adults and children, but due Continue reading

Type 1 Diabetes in Children: Signs, Symptoms, Causes and Treatment

Type 1 Diabetes in Children: Signs, Symptoms, Causes and Treatment

Type 1 diabetes (T1D) in children is a serious medical condition, where a child’s body fails to produce the hormone insulin. Insulin is a naturally occurring hormone that is produced in the pancreas, which helps the body process glucose and sugar. Glucose is a form of sugar, which is one of the biggest sources of fuel for the body. Without insulin, glucose cannot enter the cells for energy, which then leads to a build up of glucose in the blood. Too much glucose in the bloodstream is dangerous and could lead to life threatening conditions. Kids with T1D need to take insulin injections so that they can survive. When your child is first diagnosed with T1D, it can be frightening. Unlike other medical conditions, T1D has no cure as of yet. However, the good news is that there is treatment for T1D. Your child does not have to suffer throughout their life. If they adopt a healthy lifestyle, monitor their blood sugar regularly and take insulin injections as recommended by their doctor, they will live a healthy and happy life.
However, depending on their age, you will have to work out these changes together. The main change will be to learn how to regularly check and adjust your child’s blood glucose levels. You may need to check your child’s blood glucose levels at least 10 to 12 times every day. It will require a bit of practice before you can learn how to effectively keep their blood glucose levels within a healthy range. However, as you work with your diabetes team and learn more about managing diabetes, you will become confident. Talk to your child about which food they Continue reading

Diabetes services in San Diego at Scripps Health

Diabetes services in San Diego at Scripps Health

Scripps Whittier Diabetes Institute is Southern California’s leading diabetes center of excellence, committed to providing the best evidence-based diabetes screening, education and patient care in San Diego.
Founded in 1981, our mission is to improve the quality of life for individuals with pre-diabetes, gestational diabetes, Type 1 and Type 2 diabetes through innovative programs.
We offer programs in patient self-management education, clinical research, community-based diabetes care, diabetes prevention, pragmatic retinal screenings, and professional training and education.
Our dedication to diabetes care has earned Scripps Memorial Hospital La Jolla and Scripps Green Hospital recognition as San Diego’s best hospitals for diabetes and endocrinology medicine by U.S. News and World Report.
Read more about our exceptional diabetes care and offerings in the Scripps Diabetes Annual Report 2017 (PDF, 1.2 MB).
Currently, more than 29.1 million people in the United States have diabetes, and up to one-third of them do not know it. Learn more about diabetes, including the three types of diabetes: gestational diabetes, Type 1 and Type 2 diabetes.
Definition
Type 2 diabetes is a lifelong (chronic) disease in which there is a high level of sugar (glucose) in the blood. Type 2 diabetes is the most common form of diabetes.
Causes
Insulin is a hormone produced in the pancreas by special cells, called beta cells. The pancreas is below and behind the stomach. Insulin is needed to move blood sugar (glucose) into cells. Inside the cells, glucose is stored and later used for energy.
When y Continue reading

Researchers identify gene variants linked to both type 2 diabetes and CHD risk

Researchers identify gene variants linked to both type 2 diabetes and CHD risk

Type 2 diabetes (T2D) has become a global epidemic affecting more than 380 million people worldwide; yet there are knowledge gaps in understanding the etiology of type-2 diabetes. T2D is also a significant risk factor for coronary heart disease (CHD), but the biological pathways that explain the connection have remained somewhat murky. Now, in a large analysis of genetic data, published on August 28, 2017 in Nature Genetics, a team, led by researchers in the Perelman School of Medicine at the University of Pennsylvania, has first looked into what causes T2D and second clarified how T2D and CHD – the two diseases that are the leading cause of global morbidity and mortality, are linked.
Examining genome sequence information for more than 250,000 people, the researchers first uncovered 16 new diabetes genetic risk factors, and one new CHD genetic risk factor; hence providing novel insights about the mechanisms of the two diseases. They then showed that most of the sites on the genome known to be associated with higher diabetes risk are also associated with higher CHD risk. For eight of these sites, the researchers were able to identify a specific gene variant that influences risk for both diseases. The shared genetic risk factors affect biological pathways including immunity, cell proliferation, and heart development.
The findings add to the basic scientific understanding of both these major diseases and point to potential targets for future drugs.
"Identifying these gene variants linked to both type 2 diabetes and CHD risk in principle opens up opportunities to lower the ri Continue reading

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