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Early-onset And Classical Forms Of Type 2 Diabetes Show Impaired Expression Of Genes Involved In Muscle Branched-chain Amino Acids Metabolism

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism

Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism


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Early-onset and classical forms of type 2 diabetes show impaired expression of genes involved in muscle branched-chain amino acids metabolism
Scientific Reportsvolume7, Articlenumber:13850 (2017)
The molecular mechanisms responsible for the pathophysiological traits of type 2 diabetes are incompletely understood. Here we have performed transcriptomic analysis in skeletal muscle, and plasma metabolomics from subjects with classical and early-onset forms of type 2 diabetes (T2D). Focused studies were also performed in tissues from ob/ob and db/db mice. We document that T2D, both early and late onset, are characterized by reduced muscle expression of genes involved in branched-chain amino acids (BCAA) metabolism. Weighted Co-expression Networks Analysis provided support to idea that the BCAA genes are relevant in the pathophysiology of type 2 diabetes, and that mitochondrial BCAA management is impaired in skeletal muscle from T2D patients. In diabetic mice model we detected alterations in skeletal muscle proteins involved in BCAA metabolism but not in obese mice. Metabolomic analysis revealed increased levels of branched-chain keto acids (BCKA), and BCAA in plasma of T2D patients, which may result from the disruption of muscle BCAA management. Our data support the view that inhibition of genes involved in BCAA handling in skeletal muscle takes place as part of the pathophysiology of type 2 diabetes, and this occurs both in early-onset and in classical type 2 diabetes.
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You CAN beat diabetes! Strict diet, exercise and drugs helps reverse type 2 diabetes

You CAN beat diabetes! Strict diet, exercise and drugs helps reverse type 2 diabetes


You CAN beat diabetes! Strict diet, exercise and drugs helps reverse type 2 diabetes
Patientswere put on a strict diet, exercise regime and given a combination of drugs and insulin jabs in study on diabetes care
INTENSIVE therapy can reverse Type 2 diabetes in just four months, a study found.
Patients were put on a strict diet, exercise regime and combination of drugs and insulin jabs.
They received regular check-ups with a nurse and dietician.
Participants were put on a strict diet, exercise regime and combination of drugs and insulin jabs
Some 41 per cent remained symptom-free three months after stopping medication.
That compares with 21 per cent who followed the plan for two months, and 14 per cent among those who received their usual treatment.
Researchers from McMaster University, in Ontario, Canada, said patients would find the results very appealing.
Diabetics are encourages to follow a healthy diet that is low in sugar, saturated fats and salt
Diabetes occurs when the body is unable to regulate its use of glucose, causing blood sugar levels raise .
It affects more than 4million people in the UK and produces a range of symptoms that can be disabling and life-shortening.
The vast majority of patients have the Type 2 form of the disease, which involves poor sensitivity to the hormone insulin, produced in the pancreas.
It is linked to unhealthy lifestyle and obesity and generally seen as a progressive chronic condition that can be managed but not cured.
It keeps your skin younger, its healthier for your privates and 4 other reasons you should sleep nake Continue reading

Carmel Valley resident joins more than 180 diabetes advocates for the American Diabetes Associations 2017 Call to Congress Advocacy Day

Carmel Valley resident joins more than 180 diabetes advocates for the American Diabetes Associations 2017 Call to Congress Advocacy Day


Carmel Valley resident joins more than 180 diabetes advocates for the American Diabetes Associations 2017 Call to Congress Advocacy Day
(L-R) Dr Alan Saltiel, Hillary Liber, Honorable Susan Davis, Basma Abdellaoui, Rachida Abdellaoui, and Chief of Staff Matt Weiner
(L-R) Dr Alan Saltiel, Hillary Liber, Honorable Susan Davis, Basma Abdellaoui, Rachida Abdellaoui, and Chief of Staff Matt Weiner (Courtesy)
. More than 180 advocates from 33 states convened at the U.S. Capitol in Washington, D.C., for the American Diabetes Associations 2017 Call to Congress advocacy day.
The advocates, including adults and children living with type 1 and type 2 diabetes, family members of people with diabetes, researchers, physicians and diabetes care providers, participated in 188 meetings with their members of Congress and urged them to address the diabetes epidemic. In addition to people with diabetes and health care providers, advocates included more than 30 members of Team Tackle an initiative to engage professional football players to raise awareness of diabetes and prediabetes.
During the March 30 press conference, the Association outlined the state of the diabetes epidemic and called on Congress to protect access to adequate health insurance for people living with diabetes, to increase federal funding to support and drive diabetes research and programs, and to ensure that lifesaving insulin is accessible for all who need it. The Association remains dedicated to protecting the
Patient Protection and Affordable Care Act
(ACA) from repeal without an immediate replacement that prov Continue reading

Can a dual-hormone closed loop delivery systems become a “technical cure” of diabetes?

Can a dual-hormone closed loop delivery systems become a “technical cure” of diabetes?

The dual hormone (insulin and glucagon) ‘‘artificial pancreas’’: Promises and challenges
Achieving tight glycaemic control without severe hypoglycaemia still is a major challenge in insulin-treated diabetes. While curative cell based and immunological therapies could theoretically provide the ideal solution for patients with diabetes, there are still many issues to be solved. Closed-loop technologies may provide a more promising alternative for the near future, although various challenges will still need to be overcome to safely avoid hypoglycaemia and still achieve good blood glucose levels in a closed-loop setting.
From a controlling perspective, a major challenge is the use of exogenous subcutaneously (s.c.) applied insulin with a rather slow onset and long duration of action, which is unable to react fast enough to the wide and highly variable range in insulin requirements under different physiological conditions. To put a physiological break on the insulin action when blood glucose tends to go low, bihormonal artificial pancreas (AP) systems are being developed which, in addition to insulin, use human pancreas hormone glucagon to counteract the effect of insulin. Glucagon leads to a rapid conversion of hepatic glycogen (the stored form of glucose) into glucose which is then released into the bloodstream. A number of academic working groups have demonstrated short-term efficacy and safety of automated insulin and glucagon delivery among people with type 1 diabetes mellitus [[i]] [[ii]] [[iii]] [[iv]]. Glucagon’s effects on reducing caloric intake and increasin Continue reading

Dietary Supplements: Hype or Helpful?

Dietary Supplements: Hype or Helpful?


More than half of Americans take dietary supplements . You probably have a bottle of vitamins or an herbal supplement in your cupboard or medicine cabinet (I know I do!). The dietary supplement industry is big business the projection is that by 2024, the supplement market will reach $278 billion . Supplements are touted everywhere in drugstores, grocery stores, health-food stores, and, of course, on the Internet. Plus, entire stores (GNC, Vitamin Shoppe) are devoted to selling pills and potions to enhance health and performance. And lets not forget the celebrities and sports stars pushing supplements on us, as well. But are dietary supplements all theyre cracked up to be? Does swallowing a fistful of pills every morning really make you healthier?
Dietary supplements encompass a whole host of items , including vitamins and minerals, herbs and other botanicals, enzymes, and amino acids. Supplements come in a variety of forms tablets, capsules, softgels, gelcaps, liquids, and powders. Some common supplements include:
Are dietary supplements approved by the FDA?
According to the FDA , a dietary supplement is a product intended for ingestion that contains a dietary ingredient intended to add further nutritional value to (supplement) the diet. From that definition, taking a supplement sounds like a pretty good idea. Taking a multivitamin every day, for example, seems pretty benign, and for the most part, it is. However, the FDA does not approve dietary supplements. This means that supplement manufacturers are not required to obtain FDA approval to market their products. Continue reading

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