Drug to Reverse Type 2 Diabetes Passes Critical Test in Mice
In a groundbreaking study, researchers found that they were able to effectively reverse type 2 diabetes symptoms in mice by administering a daily oral drug with no adverse side effects.
Millions of people worldwide suffer from diabetes, particularly type 2 diabetes—which accounts for nearly 90% of all documented cases. If the medication is successful in humans, it would revolutionize how diabetes is treated.
Type 2 diabetes is common in older individuals whose bodies’ do not respond as they should to insulin, the key hormone that regulates blood sugar. Most diabetics opt for insulin injections to control their blood sugar levels, while others rely on restrictive diets to avoid sugar altogether. Though both of these techniques help manage the disease, they cannot cure it. They come with a number of potential of side effects including weight gain and diarrhea.
What’s more, dependence on insulin injections may lead to insulin resistance. And if untreated, type 2 diabetes can lead to health problems like kidney disease, nerve damage, and vision problems.
The proposed daily pill would restore the body’s sensitivity to insulin and increase the activity of the insulin receptor in the liver. Researchers believe this could introduce a new therapeutic strategy to treating type 2 diabetes and hopefully result in a lessened reliance on insulin injections by people with adult-onset diabetes.
Here’s Andy Coghlan, reporting for New Scientist:
The drug works by inhibiting an enzyme called low molecular weight protein tyrosine phosphatase (LMPTP), which seems to contribute to cell Continue reading