DNA Methylation Links Genetics, Fetal Environment, And An Unhealthy Lifestyle To The Development Of Type 2 Diabetes

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes

DNA methylation links genetics, fetal environment, and an unhealthy lifestyle to the development of type 2 diabetes
Type 2 diabetes is a complex trait with both environmental and hereditary factors contributing to the overall pathogenesis. One link between genes, environment, and disease is epigenetics influencing gene transcription and, consequently, organ function. Genome-wide studies have shown altered DNA methylation in tissues important for glucose homeostasis including pancreas, liver, skeletal muscle, and adipose tissue from subjects with type 2 diabetes compared with nondiabetic controls. Factors predisposing for type 2 diabetes including an adverse intrauterine environment, increasing age, overweight, physical inactivity, a family history of the disease, and an unhealthy diet have all shown to affect the DNA methylation pattern in target tissues for insulin resistance in humans. Epigenetics including DNA methylation may therefore improve our understanding of the type 2 diabetes pathogenesis, contribute to development of novel treatments, and be a useful tool to identify individuals at risk for developing the disease.
EpigeneticsDNA methylationType 2 diabetesInsulin resistanceAgingObesityIntrauterine environmentGenetics
Type 2 diabetes is one of the most common chronic metabolic diseases in developed countries [ 1 ]. This form of diabetes is a consequence of the target tissues becoming resistant to the effects of insulin and the failure of pancreatic -cells to produce enough insulin. It is shown that type 2 diabetes develops with age, physical inactivity, and o Continue reading

Rate this article
Total 1 ratings
Ramadan Fasting and Type 2 Diabetes

Ramadan Fasting and Type 2 Diabetes

Home / Conditions / Type 2 Diabetes / Ramadan Fasting and Type 2 Diabetes
Fasting found to lead to deterioration of glycemic control in people with type 2 diabetes.
Ramadan is the ninth month of the Islamic calendar and takes place once a year. Muslims all over the world observe this month as a month of fasting to commemorate the first revelation of the Quran to the prophet Muhammad. Fasting requires abstinence from any food, drink, and smoking from sunrise to sunset. Although patients with type 2 diabetes are exempt from fasting during Ramadan, most individuals still fast. People with type 2 diabetes who do fast increase their risk of developing hypo- and hyperglycemic episodes. This raises concerns as to whether fasting during Ramadan is safe for individuals with diabetes. This article observes studies determining whether fasting during Ramadan affects glycemic control in people with type 2.
During the holy month of Ramadan, individuals consume traditional foods that are high in carbohydrates, fats, and protein. Past studies have shown that foods consumed during Ramadan pose a risk of hyperglycemia among people with diabetes. Moreover, reports of low energy levels during Ramadan were observed among those fasting who have diabetes. In addition, repetitive dietary and sleep changes during Ramadan may induce changes in hormones, which regulate energy metabolism. In healthy adults, intermittent fasting caused an increase in insulin-mediated glucose uptake. Furthermore, studies have suggested that although Ramadan fasting does not affect glycemic control in people with di Continue reading

Eggs & Diabetes: Are Eggs Good For Diabetics? Know the Facts!

Eggs & Diabetes: Are Eggs Good For Diabetics? Know the Facts!

Eggs & Diabetes: Can Diabetics Eat Eggs? Know the Facts
Eggs & Diabetes: Can Diabetics Eat Eggs? Know the Facts
In Diabetes, one has to be really particular with the type of lifestyle one has, including the food habits and the amount of physical exercise .It is often very important to take extreme care of your body when you are suffering from diabetes as the disease brings in a lot of other related complications. As such, there are numerous questions on the inclusion of certain foods in the diet. One such food is an egg. Eggs are, without a doubt, a great source of protein , vitamins , and several other nutrients which can be considered really healthy. However, the doubt and the concern arises due to the eggs being very rich in cholesterol
In this article, we try to find out the answer to the question: Should Eggs be Included in the diet of a person suffering from diabetes? We shall delve deep and analyze whether it is safe to consume eggs for a diabetes patient.
How to Include Eggs in Your Daily Diet in Order to Stay Healthy?
Before we delve deep and try to analyze whether the consumption of eggs is healthy for a person suffering from diabetes, we need to understand a few facts related to eggs. Following are a few facts which might help us to understand the relation between diabetes and eggs:
Eggs contain a very high level of cholesterol . It is because of this reason that most of the studies suggest that eggs should not be consumed if a person is suffering from diabetes. This can lead to higher risks of contracting several heart- related issues.
Besides, the egg Continue reading

Common Health Risks and Associated Symptoms of Diabetes

Common Health Risks and Associated Symptoms of Diabetes

Common Health Risks and Associated Symptoms of Diabetes
Sponsored Content by EKF Diagnostics Aug 2 2017
Diabetes is a chronic metabolic disorder that affects blood glucose control, and has become a growing problem across the world. From 1980 to 2014, the prevalence of diabetes grew from 4.7% to 8.5% worldwide, with the number of individuals affected by this disease increasing from 108 million to 422 million, respectively.1
Credit: Syda Productions/Shutterstock.com
It is estimated that the number of people worldwide with diabetes will increase to 642 million by 2040, according to the IDF diabetes atlas, indicating a serious healthcare crisis for both providers and patients in the future.2
In line with this, healthcare costs are also projected to greatly expand, in the same way that it has in recent years. In just a period of 5 years, from 2007 to 2012, the overall healthcare spending associated with diabetes increased by 41%, from $174 billion to $245 billion.3
Diabetes prevalence is mostly seen in developing countries, reflecting a high proportion of the economic burden of this disease. Particularly in Asian countries, there is a high prevalence of diabetes cases and these are likely to grow further.4
In fact, Asian countries have the highest prevalence rates, representing 60% of the global population of people with diabetes, largely due to factors associated with rapid development. The three most common factors related to this increase are industrialization, socio-economic growth and urbanization. 4
In India, diabetes cases are increasing in epidemic proportions, Continue reading

Massage, Diabetes Type 1 , &Hypoglycemia

Massage, Diabetes Type 1 , &Hypoglycemia

The gateway to quality education & improved client care
PART 1 OF 2: Diabetes mellitus (DM) is a group of diseases characterized by chronic elevated blood glucose levels. It is caused by insufficient amounts of insulin, resistance to insulin by the cells, or both. Several types of DM have been identified such as type 1 & type 2. Gestational diabetes discussed HERE .
In type 1 DM, pancreatic beta cells are damaged or destroyed, creating a lack of insulin. Without insulin, glucose cannot enter cells. Hence the individual develops a dependence on insulin. Another term used to describe type 1 DM is insulin-dependent diabetes mellitus (IDDM). Type 1 accounts for approximately 5-10% of all diabetes cases (1) & affects approximately 1.25 million people in the United States (2).
Glucose is the bodys main source of fuel & energy. Glucose can only enter cells with the help of the hormone, insulin. Insulin is produced by beta cells located in the pancreas. When glucose enters body cells, blood glucose levels are lowered. Without insulin, glucose does not enter the
cells & blood glucose levels remain high called hyperglycemia.
Signs and symptoms of DM are excessive urination, excessive thirst, & excessive hunger. Others include fatigue, blurred vision, unexplained weight loss, & increased frequency of infections. Persistent hyperglycemia damages cells & leads to complications such as vision problems or diabetic retinopathy, reduced sensations or diabetic neuropathy, & kidney, cardiovascular, & neurologic diseases.
Treatment consists of a lifelong commitment of monitoring blood Continue reading

No more pages to load

Popular Articles

  • Yes! A Low-Carb Lifestyle Can be Healthy for Type 2 Diabetes

    Your body requires many things in order to be healthy: sleep, water, micronutrients such as vitamins and minerals, as well as the macronutrients protein and fat. What it doesn’t NEED, from a scientific perspective, is carbohydrates. While a plate of pasta may well be comfort food, it’s not a power food. Your body will turn that simple carbohydrate into glucose (a sugar), which will be burned b ...

  • Lifestyle & Healthy Eating Tips For Diabetes Type 2

    Sometimes, we all need a little nudge of motivation towards making healthy changes to our lifestyle and our diet. The motivation can be as simple and straight forward as losing weight, or just being healthy to live a long and prosperous life. The motivation and the desire may come easy for those who do not have the burden of keeping their blood sugar levels in constant check. But when you have typ ...

  • Type 2 Diabetes – Reversal with Lifestyle Change

    MEET DAMIEN – (2004 – 2013) Doing no exercise, 19 stone in weight, a smoker, on medication for gout and blood pressure, diagnosed with Type 2 Diabetes and taking Diabetes medication to reduce the damage caused by high blood glucose to his eyes, heart, kidneys, limbs in fact, the entire body. Damien’s diabetes consultant was not a happy man. Damien needed to change and admits not being happy ...

  • The lifestyle changes that can cut type 2 diabetes risk

    The lifestyle changes that can cut type 2 diabetes risk By Dr Rangan Chatterjee Doctor in the House These are external links and will open in a new window Type 2 diabetes affects approximately 3.5 million people in this country and is thought to cost the UK around 20bn per year in both direct and indirect costs. This is a staggering amount of money spent on a condition largely caused by our ...

  • Ken's Engineered Type 1 Diabetes Whole Food Plant Based Low Fat Lifestyle

    Previous experiences with my doctors were extremely difficult because they wanted to control my Type 1 diabetes by prescribing specific medication doses and defining what I should eat. But, none of that was working. I felt extremely diseased and disabled. I was kind of terrified from all that and so decided to apply the techniques of my profession: fault analysis and electronic design. In addition ...

  • Regular, early lifestyle changes key to reducing type 2 diabetes & cardiovascular disease

    Regular and early lifestyle changes key to reducing type 2 diabetes and cardiovascular disease in young South Asians, study suggests Regular and early one-to-one educational sessions on healthy diet and lifestyle could reduce the risk of developing type 2 diabetes and cardiovascular disease (CVD) in young South Asians, a new research published today in BMC Medicine suggests. Unlike previous studie ...

  • Diabetes, space-saving DNA, and a very important gene

    Last week, you might recall that we looked at a gene called PDX1, a critical DNA sequence that plays a role in the development of a certain type of diabetes—and the actual development of the pancreas in human embryos. Now, as Diabetes Awareness Month continues, let’s take a look at another gene with major implications for sugar regulation. This week we’re focusing on KLF11, an important play ...

  • Is going gluten-free giving you diabetes? New study links diet with the disease

    Gluten-free diets adopted by growing numbers of health-conscious consumers enhance the risk of developing Type 2 diabetes, scientists have warned. A major study by Harvard University suggests that ingesting only small amounts of the protein, or avoiding it altogether, increases the danger of diabetes by as much as 13 per cent. The findings are likely to horrify the rising number of people who are ...

  • Study Links Vaccine Induced Immune Overload to Autism, Diabetes, Obesity

    A new vaccine study published in Molecular and Genetic Medicine is bringing to the forefront the disturbing connection between the dramatic expansion in the quantity of routine childhood vaccines administered and a corresponding increase in inflammation-associated disorders. Titled, "Review of Vaccine Induced Immune Overload and the Resulting Epidemics of Type 1 Diabetes and Metabolic Syndrome, Em ...

Related Articles