Diabetes Of The Brain Is Connected To Alzheimer's, New Study Shows

Diabetes of the brain is connected to Alzheimer's, new study shows

There’s growing evidence that Alzheimer’s disease resembles a new form of diabetes known as type 3.
A National Institute of Aging study now shows how high glucose concentrations in brain tissue may result from abnormal glucose metabolism, eventually leading to the dangerous plaques and tangles characteristic of Alzheimer’s disease — the neurodegenerative disease that represents the major cause of dementia.
“To the best of our knowledge,” the study says, “this report is the first to measure brain-tissue glucose concentrations and ... demonstrate their relationships with both severity of Alzheimer’s disease pathology and the expression of Alzheimer’s disease symptoms,” said the study published Monday in Alzheimer’s & Dementia, a journal of the Alzheimer’s Association.
The study also sets “the stage for future studies that may uncover therapeutic interventions targeting brain glucose dysregulation,” says the study led by Madhav Thambisetty of NIA’s Laboratory for Behavioral Neuroscience. He’s also associated with Johns Hopkins Medicine.
Study results, he said, give him no reason to change the advice he gives patients with memory problems: “What is good for the heart is good for the brain,” including a healthy diet, exercise, adequate sleep and brain-stimulating activities.
In Alzheimer’s disease, accumulation of senile plaques (deposits of amyloid beta in the gray matter of the brain) and neurofibrillary tangles (aggregations of tau protein), adversely affect brain function, leading to the loss of neurons and memory.
The study describes ho Continue reading

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He’s Lived with Type 1 Diabetes for 71 Year

The life expectancy of type 1 diabetes has always been one of the worries, that myself as a parent to two kids with Type 1 always has in the back of their mind.
You read many articles and an overwhelming amount of statistics that say, that type 1 diabetes takes 5-10 years off of someone’s life. How can you swallow those words when you read them right in front of you, as a parent, or as someone who lives with type 1 diabetes?
It’s difficult to say the least, but even difficult doesn’t cover it.
And then you read stories like those of Mr. Richard Vaughn, who has lived with Type 1 diabetes for 71 years, at the age of 6 years old, the same age, coincidentally as my son was diagnosed. That glimmer of “HOPE” reignites back into your heart. Possibility replaces the worry and fear that once took over you.
Understanding exactly what Richard has gone through in terms of diabetes treatment and management over the past 71 years is what really makes his story so amazing.
Think about the advancement in medicine throughout this time. Consider the treatment options for Richard and his parents when he was first diagnosed and compare them to the ones available today. Things have changed, and his story is nothing short of remarkable.
My two Type 1 kids and I had the honor of meeting him and his wife in the summer of 2015 at the Friends for Life Conference.
My son and I actually went to one of the sessions where Richard was speaking because I thought it was very important for my son, who at the time was 11 years old, having lived with Type 1 for 5 years up until that point, to hear t Continue reading

Mastery in Diabetes Management: New Diabetes Diagnosis Criteria Req'd for Asian Patients?

Nina Suda, MD
Nina Suda, MD, of Albert Einstein College of Medicine and Montefiore Medical Center in New York, spoke with MedPage Today at AACE 2017, the annual meeting of the American Association of Clinical Endocrinologists, about a case study involving a young Southeast Asian woman presenting with newly diagnosed type 2 diabetes and advanced diabetic nephropathy. Suda's full poster may be downloaded by clicking here.
Following is a transcript of her remarks:
The title of my poster is 'Newly diagnosed insulin-dependent diabetic nephropathy: Do we need different criteria for screening and diagnosis of diabetes in South-East Asians?'
This was a 27-year-old female, she was Sri Lankan, and she came to us with a neck abscess that she had been complaining of for two weeks. She initially presented to an urgent care center and they had said, "Here's some amoxicillin, Advil -- it should get better over time." Unfortunately, it didn't and then she came to Montefiore Medical Center where she presented in the ED, and with which she complained of an abscess that was growing.
What we do know about her is that she was diagnosed with hypertension two years ago. This was on a routine physical. She had seen her primary care doctor, she told us, and they started her on Enalapril. She's been completely compliant with it. So, the only meds that she was taking was the amoxicillin and the Advil, which was for the abscess that she had for about a week. She said that she was on no other medications.
Her family, they didn't have any medical conditions other than diabetes that were diagnosed, and a Continue reading

Study confirms link between high blood pressure and diabetes

A new study has confirmed people with high blood pressure have a much greater chance of developing diabetes.
The study looked at the health records of four million adults in the United Kingdom and clarified earlier research which had been inconclusive.
But the jury is still out on whether diabetes is actually caused by high blood pressure.
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Professor Anoushka Patel, chief scientist at the George Institute for Global Health, said the new data was quite definitive.
She said those with high blood pressure had an almost 60 per cent greater chance of developing diabetes.
"The study used data from routine GP visits, so the data was very reliable and ... a very large ... number of patients were involved," she said.
"We can't say that it's definitely caused by high blood pressure, the study design doesn't allow us to make that conclusion. It's highly suggested."
Professor Patel said the study showed high blood pressure often preceded diabetes and not the other way around.
"The study ... excluded people at the beginning who already had diabetes, so it only included people without diabetes, without heart disease," she said.
"[It] looked at the heart pressure levels then looked at people over a period of time and looked at whether ... they developed diabetes.
"It does actually present that relationship over time. Blood pressure's respective to diabetes rather than the reverse."
However, Professor Patel said researchers would need to do more to prove there was a causal link and investigate whether lowering high bloo Continue reading

Type 1 diabetes | IDDM

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If the body’s insulin production is insufficient or stopped, is called as type-1 diabetes. It is caused by the autoimmune disorder and needs to treat with insulin shots.
Type-1 diabetes is also known as Insulin-Dependent Diabetes Mellitus (IDDM) and juvenile diabetes. It is spelled as type-i diabetes, diabetes one and diabetes 1.
Formerly, it was known as "juvenile diabetes," because it represents a majority of the cases in children, teenagers, or young adults, but now we came to know that it can also affect adults.
Among youth ages younger than ten years, the rate of new cases of type 1 diabetes was 19.7 per 100,000 each year for type 1 diabetes. Among youth aged ten years or older, the rate of new cases was 18.6 per 100,000 each year for type 1 diabetes.
What is Type-1 diabetes?
Only about 10% of the people with diabetes are type 1, remaining 90% are type 2.
What is type 1 diabetes? Type 1 diabetes develops due to the autoimmune destruction of the beta cells in the islet cells of Langerhans in the pancreas. It usually ends up with more or less absolute deficiency of insulin. This destruction process starts a long time before the illness diagnosed. Thus, there exists an opportunity for prevention of diabetes in the future.
To halt or delay pancreas destruction, you should know your type 1 diabetes risk factors and type 1 diabetes symptoms for early type 1 diabetes diagnosis to stop or slow down beta cells destruction.
Type-1 diabetes needs insulin treatment and healthy diabetes lifestyle change for proper blood-glucose level maintenance and to avoid diabete Continue reading