Diabetes Drug Might Also Help Treat Heart Disease
Researchers say the drug trodusquemine has the potential to reduce arterial fat and perhaps reverse atherosclerosis.
Can an experimental diabetes drug change how we treat heart disease?
In a new study, researchers tout the drug trodusquemine’s ability to “melt away” arterial fat in preclinical trials involving mice.
The research, conducted at the University of Aberdeen in Scotland, is the first of its kind to demonstrate the drug’s ability to reverse atherosclerosis — in some cases with as little as one dose.
“We could show that using the drug chronically, once a week for five weeks or just once toward the end of the study, both resulted in significantly lower atherosclerotic plaque area. It also lowered serum lipids (triglycerides and cholesterol),” Mirela Delibegovic, a study author and a professor in diabetic medicine at the University of Aberdeen, told Healthline.
Mice in the study were treated with either saline (for the control group), a single trodusquemine dose, or multiple doses.
For mice receiving single or multiple doses, there was a decrease in the measured plaque formation while the control group remained unchanged.
The study at Aberdeen is exciting because, in Delibegovic's words, “[The drug] seemed to completely reverse the effects of” atherosclerosis.
Tackling a major killer
Heart disease is the leading cause of death for both men and women in the United States, according to the Centers for Disease Control and Prevention (CDC).
An estimated 610,000 people die per year from heart disease in the United States, accounting for roughly 25 percen Continue reading