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Curcumin Extract For Prevention Of Type 2 Diabetes

Curcumin Extract for Prevention of Type 2 Diabetes

Curcumin Extract for Prevention of Type 2 Diabetes

Abstract
OBJECTIVE To assess the efficacy of curcumin in delaying development of type 2 diabetes mellitus (T2DM) in the prediabetic population.
RESEARCH DESIGN AND METHODS This randomized, double-blinded, placebo- controlled trial included subjects (n = 240) with criteria of prediabetes. All subjects were randomly assigned to receive either curcumin or placebo capsules for 9 months. To assess the T2DM progression after curcumin treatments and to determine the number of subjects progressing to T2DM, changes in β-cell functions (homeostasis model assessment [HOMA]-β, C-peptide, and proinsulin/insulin), insulin resistance (HOMA-IR), anti-inflammatory cytokine (adiponectin), and other parameters were monitored at the baseline and at 3-, 6-, and 9-month visits during the course of intervention.
RESULTS After 9 months of treatment, 16.4% of subjects in the placebo group were diagnosed with T2DM, whereas none were diagnosed with T2DM in the curcumin-treated group. In addition, the curcumin-treated group showed a better overall function of β-cells, with higher HOMA-β (61.58 vs. 48.72; P < 0.01) and lower C-peptide (1.7 vs. 2.17; P < 0.05). The curcumin-treated group showed a lower level of HOMA-IR (3.22 vs. 4.04; P < 0.001) and higher adiponectin (22.46 vs. 18.45; P < 0.05) when compared with the placebo group.
CONCLUSIONS A 9-month curcumin intervention in a prediabetic population significantly lowered the number of prediabetic individuals who eventually developed T2DM. In addition, the curcumin treatment appeared to improve overall function of β-cells, with very minor advers Continue reading

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Prepping With Type 1 Diabetes

Prepping With Type 1 Diabetes

Type 1 diabetes — also called Juvenile Diabetes — shook our prepping plans to their foundations. While I was stockpiling food, learning to make cheese, and writing the occasional post for the Survival Mom, my 9 year-old daughter’s body was attacking itself and she was diagnosed with Type 1 Diabetes.
Just a short time later I found myself trying to find answers for prepping with Type 1 Diabetes.
A T1D diagnosis is a life sentence of finger pokes and insulin administration. And because it’s genetic, we now know our other children are at risk.
What’s a survival mom to do? I didn’t even wait for the shock to wear off before I took to the internet seeking advice from the preparedness community…and was extremely disappointed with the meager information available. (I’ve included the links to those I found even a little bit helpful to save you time.) Even expert Mormon preppers who have so much information and resources had little to offer.
NOTE: This post is specific to Type 1 Diabetes, NOT Type 2. Please keep the differences in mind when you post comments and suggestions. Finding ways to prepare for a serious disease like this is scary. Suggestions that simple adjustments, like changing the food we have stored, as if we wouldn’t have already done that if it would resolve the issue, are more hurtful than helpful.
*Disclaimer: I am not a doctor, attorney, engineer, moralist, spiritual adviser, survivalist, or millionaire. Use the attached links and their information at your own risk. I’ve simply put together what’s on the net and what I’ve personally experie Continue reading

Are Microbiome Changes a Cause or Symptom of Type 1 Diabetes?

Are Microbiome Changes a Cause or Symptom of Type 1 Diabetes?

Two years ago, I interviewed Alex Kostic, who was then a postdoctoral fellow at the Broad Institute of MIT and Harvard exploring the microbiome’s connection to type 1 diabetes. His work studying children in Finland and parts of neighboring Russia showed that the microbiomes of children with type 1 diabetes were drastically different from the microbiomes of those without the disease. Now Kostic is running his own lab at the Joslin Diabetes Center in Boston, and investigating questions such as whether or not the changes in the microbiome are causing disease or are merely a symptom of it. He is also looking at the microbiota of the Joslin medalists—those who have lived with type 1 diabetes for more than fifty years. About 20-30 percent of those medalists still produce a trace amount of insulin, and Kostic is trying to understand whether that insulin production can be explained by differences in those medalists’ microbiomes.
Jessica Dunne, director of discovery research at JDRF, which is funding Kostic’s study of the medalists commented on the new lens that Kostic is bringing to the study of T1D. “We’re often thinking about how the microbiome is affecting the immune system. He took a different tack that we haven’t seen anyone take: what’s the role of the microbiome on beta cells? To me, it’s a completely novel approach; it’s very out of the box thinking in terms of how the microbiome can affect residual insulin production in type 1.” The question is, she continued, “can we reawaken those sleeping beta cells by modifying the microbiome?” Dr. George King Continue reading

Low Thyroid Hormone Raises Risk for Type 2 Diabetes

Low Thyroid Hormone Raises Risk for Type 2 Diabetes

People with prediabetes and low thyroid function were more than twice as likely to progress to full-blown type 2 diabetes compared to those with normal thyroid-hormone levels in a new study1 published September 30 in the journal BMC Medicine.
For the study, researchers from the Erasmus Medical Center in the Netherlands followed 8,492 adults, ages 54 to 74, for nearly eight years. At the start, 1,338 had prediabetes and 7,114 had normal blood sugar levels. After 7.9 years, 798 had developed type 2 diabetes. Overall, low thyroid function—even in the low-normal range—increased risk for diabetes by 13%. But among those with prediabetes, the risk for progressing to type 2 diabetes ranged from 15% for those with normal thyroid function to 35% for those with signs of low function. Even “low normal” thyroid functioning increased risk.
It’s the first large study to track low and low-normal thyroid function and diabetes risk. “There are no other studies addressing the relation between diabetes and thyroid function in the euthyroid range or in individuals with prediabetes,” the researchers note. Lead study author Layal Chaker, MD2 a Research and Curriculum Fellow at the Harvard T.H. Chan School of Public Health and a research fellow in the Department of Endocrinology and Epidemiology at the Erasmus Medical Center told EndocrineWeb that its too soon to recommend thyroid screening tests for people with prediabetes. And while treating low thyroid can help people with type 2 control their blood sugar, it’s not known whether treatment could prevent or delay it. “Our findi Continue reading

My Insulin Pump is How Old?

My Insulin Pump is How Old?

Wait, my insulin pump is how old? Has it been five years already? I thought I had another year before it was time to obtain a new pump. I was wrong. In January I made an inquiry to Medtronic about my warranty and sure enough my warranty was due to expire on January 23, 2017. Wow five years went by fast.
It is a big deal to change insulin pumps and this time I intended to change brands so it was important to get moving. Last year following the Medtronic / United Health Care agreement; I intended to use the Accu-Chek pump provided when I made the change as it included a built in Dexcom feature. I thought I had a year before that needed to happen. I went to the Accu-Chek website and I discovered that effective January 1, 2017. According to Diabetes Mine, Roche was not taking new orders for insulin pumps and it was their intent to exit the business as the warranties for their products expired. Gulp!
I realized when I made my intention known last year that Accu-Chek was the weak sister in the insulin pump business but I also knew that they were a strong company, I liked the Accu-Chek meter and everyone I talked to liked their pump. Also, I like that Roche is a local employer in Indianapolis and I know and like people who work at there so that was a double bonus. For me, the local employer is a big deal and with the other things I thought well if they can integrate the Dexcom (most pump manufacturers seem to be doing that) then this looks like a winning combination. Alas it was not to be.
So my next check in was with Animas who does have Dexcom integration in their pumps, they ar Continue reading

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