
Clinical features and treatment of maturity onset diabetes of the young (MODY)
Clinical features and treatment of maturity onset diabetes of the young (MODY)
1Department of Endocrinology, Singapore General Hospital, Singapore
2Department of Endocrinology, National University Hospital, Singapore
Correspondence: Daphne SL Gardner, Department of Endocrinology, Singapore General Hospital, Block 6, Level 6, Outram Road, Singapore 169608, Tel +65 6321 4523, Email [email protected]
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Copyright 2012 Gardner and Tai, publisher and licensee Dove Medical Press Ltd.
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Maturity onset diabetes of the young (MODY) is a heterogeneous group of disorders that result in -cell dysfunction. It is rare, accounting for just 1%2% of all diabetes. It is often misdiagnosed as type 1 or type 2 diabetes, as it is often difficult to distinguish MODY from these two forms. However, diagnosis allows appropriate individualized care, depending on the genetic etiology, and allows prognostication in family members. In this review, we discuss features of the common causes of MODY, as well as the treatment and diagnosis of MODY.
Keywords: type 1 diabetes, type 2 diabetes, HNF1A, HNF4A, HNF1B, GCK
Maturity onset diabetes of the young (MODY) was a term first used in the 1970s 1 , 2 to describe inheritable diabetes distinct from type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes. In these initial reports, MODY patient
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