Clinical Features And Treatment Of Maturity Onset Diabetes Of The Young (MODY)

Clinical features and treatment of maturity onset diabetes of the young (MODY)

Clinical features and treatment of maturity onset diabetes of the young (MODY)
1Department of Endocrinology, Singapore General Hospital, Singapore
2Department of Endocrinology, National University Hospital, Singapore
Correspondence: Daphne SL Gardner, Department of Endocrinology, Singapore General Hospital, Block 6, Level 6, Outram Road, Singapore 169608, Tel +65 6321 4523, Email [email protected]
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Copyright 2012 Gardner and Tai, publisher and licensee Dove Medical Press Ltd.
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Maturity onset diabetes of the young (MODY) is a heterogeneous group of disorders that result in -cell dysfunction. It is rare, accounting for just 1%2% of all diabetes. It is often misdiagnosed as type 1 or type 2 diabetes, as it is often difficult to distinguish MODY from these two forms. However, diagnosis allows appropriate individualized care, depending on the genetic etiology, and allows prognostication in family members. In this review, we discuss features of the common causes of MODY, as well as the treatment and diagnosis of MODY.
Keywords: type 1 diabetes, type 2 diabetes, HNF1A, HNF4A, HNF1B, GCK
Maturity onset diabetes of the young (MODY) was a term first used in the 1970s 1 , 2 to describe inheritable diabetes distinct from type 1 (insulin-dependent) and type 2 (noninsulin-dependent) diabetes. In these initial reports, MODY patient Continue reading

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Postmenopausal Night Sweats Tied to Diabetes Risk

Postmenopausal Night Sweats Tied to Diabetes Risk
Women who have postmenopausal vasomotor symptoms (VMS), especially night sweats, have a higher risk for type 2 diabetes, according to a study published December 6 in Menopause. Further, the excess risk increased with the severity and duration of women's symptoms, the researchers found.
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Age At Menopause and Type 2 Diabetes Risk

Home / Conditions / Type 2 Diabetes / Age At Menopause and Type 2 Diabetes Risk
Age At Menopause and Type 2 Diabetes Risk
Early onset menopause linked to increased risk of type 2 diabetes in a cohort study.
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Type 2 diabetes is a major risk factor for cardiovascular disease, however, it is unclear if menopause is associated with the risk of developing type 2 diabetes. Animal studies have shown that estradiol decreases the amount of adipose tissues and has a protective role in the metabolism of glucose. Other trials have also shown that postmenopausal women on oral estrogen therapy have a decreased risk of developing type 2 diabetes. Therefore, the aim of this study was to investigate the association betwe Continue reading

Bart Roep, Ph.D., Has Type 1 Diabetes Cure in His Sights

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One of the new insights is that diabetes is very diverse, he said. Based on Continue reading