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Can A High Fat Paleo Diet Cause Obesity And Diabetes? Maybe, Unless

Can a high fat Paleo Diet cause obesity and diabetes? Maybe, unless

Can a high fat Paleo Diet cause obesity and diabetes? Maybe, unless

Current evidence indicates obesity and other metabolic disorders such as type 2 diabetes and insulin resistance are influenced by host genetics and lifestyle. This cascade of ever growing diseases is also associated with low-grade inflammation, as indicated by an overabundance of biomarkers in serum. What initiates or triggers the inflammation associated with these metabolic disorders?
Multiple studies in humans and mice have demonstrated that a high fat diet can trigger inflammation (see references below). But a high fat diet alone is not the whole story. If it were, a lot of Paleo dieters would be in trouble. It seems what might be missing from that high fat diet and the gut bugs deep in the gut hold the answer to what triggers the inflammation.
Every person on earth has two genomes. Our human genome, which is a mash up and shuffled deck of DNA from mom and dad, is the one we are familiar with and, for better or worse, stuck with. Our second genome is more dynamic and made up of trillions of bacteria we initially receive during birth from mom and continuously throughout life from the people we hang with, to the foods we eat, and the places we live. Numbering in the thousands of species, our microbial friends (and foe) outnumber our human cells 10 to 1. In other words, humans are 90% microbe and only 10% human. Humbling.
Spawned by the success and technical achievements of the Human Genome Project, an explosion in our understanding of the role of the microbiome (all the genes of our gut microbiota) in human health has literally flipped modern medicine and the understanding Continue reading

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Essential Oils for Diabetes: 6 Ways for Better Management

Essential Oils for Diabetes: 6 Ways for Better Management

Although there isn't a defined cure, diabetes can be managed with diet and lifestyle and, often, medication. One way to boost its management is with essential oils for diabetes, used in various ways to improve insulin sensitivity, manage body composition, and improve overall digestive wellness.
Diabetes is one of the more widespread metabolic, chronic illnesses of our time. It's estimated that around 10% of the population is diagnosed with diabetes, while another 8 million people likely have it without being diagnosed. (1)
In this article, you'll learn about:
Essential Oils for Diabetes and the Body
Aromatherapy and Essential Oils for Diabetes
6 Ways to Use Essential Oils for Diabetes Management
Essential Oils for Diabetes and the Body
For a refresher on what diabetes is and how it works in the body, we can look to the American Diabetes Association for their summary of the more common variation of diabetes, type 2:
If you have type 2 diabetes your body does not use insulin properly. This is called insulin resistance. At first, your pancreas makes extra insulin to make up for it. But, over time it isn't able to keep up and can't make enough insulin to keep your blood glucose at normal levels. (2)
On the other hand, type 1 diabetes is genetic and behaves differently:
In type 1 diabetes, the body does not produce insulin. The body breaks down the sugars and starches you eat into a simple sugar called glucose, which it uses for energy. Insulin is a hormone that the body needs to get glucose from the bloodstream into the cells of the body. (3)
It's important to have an understan Continue reading

11-year-old boy walking across US to raise diabetes awareness

11-year-old boy walking across US to raise diabetes awareness

Editors Note: Noah and his family are moving a little slower than planned, they will be in Ogden later next week. A previous version of the story said Noah is walking to the northeastern tip of the United States, he is walking to the northwestern.
This week Noah Barnes and his father Robert Barnes will walk through Ogden on their journey from from Key West, Florida to Blaine, Washington.
Although walking across the United States is already an uncommon feat, the route this father and son team are taking is an especially unique one — tip to tip rather than straight across the country. Noah and his dad aren’t walking just to be unique, however.
Noah was diagnosed with type one diabetes at 16 months old. Now at age 11, he is working to raise awareness for the disease and money to help cure it with his cross country journey entitled “Noah’s March.”
When Noah was 10, he told his parents he didn’t want to be a diabetic anymore, so the three of them began looking up how close researchers were to finding a cure.
“That was kind of how it started, (with Noah’s question) ‘How do I quit being a diabetic?’” Joanne Barnes, Noah’s mom, said.
Noah was excited to learn a cure could happen in his lifetime, Joanne said. However, for that to be possible, there had to be sufficient funding for research.
Noah wanted to help researchers have this necessary money. After discovering his dad didn’t earn enough to foot the bill, Noah began learning how fundraisers for research money were conducted as part of his home school curriculum.
Story continues after image.
The idea to Continue reading

Pre-treated blood stem cells reverse type 1 diabetes in mice

Pre-treated blood stem cells reverse type 1 diabetes in mice

Type 1 diabetes is caused by an immune attack on the pancreatic beta cells that produce insulin. To curb the attack, some researchers have tried rebooting patients’ immune systems with an autologous bone-marrow transplant, infusing them with their own blood stem cells. But this method has had only partial success.
New research in today’s Science Translational Medicine suggests a reason why.
“We found that in diabetes, blood stem cells are defective, promoting inflammation and possibly leading to the onset of disease,” says Paolo Fiorina, MD, PhD, of Boston Children’s Hospital, senior investigator on the study.
But they also found that the defect can be fixed — by pre-treating the blood stem cells with small molecules or with gene therapy, to get them to make more of a protein called PD-L1.
In experiments, the treated stem cells homed to the pancreas and reversed hyperglycemia in diabetic mice, curing almost all of them of diabetes in the short term. One third maintained normal blood sugar levels for the duration of their lives.
In a dish, the modified blood stem cells curbed the autoimmune reaction in cells from both mice and humans.
“There’s really a reshaping of the immune system when you inject these cells,” says Fiorina, a researcher in the Division of Nephrology at Boston Children’s.
The powers of PD-L1
Fiorina, Moufida Ben Nasr, PhD, and colleagues began by using gene expression profiling to find out what proteins blood stem cells make. They discovered that blood stem cells from diabetic mice and humans have alterations in the network of genetic re Continue reading

Finnish Researchers Set to Start Type 1 Diabetes Vaccine Trials?

Finnish Researchers Set to Start Type 1 Diabetes Vaccine Trials?

In July 2017, it was announced that Finnish researchers would begin human trials of a Type 1 diabetes vaccine in 2018.
On 19 July 2017, the Finnish news web site Yle reported that a group of Finnish researchers had developed a vaccine for Type 1 diabetes, and that human trials were set to begin in 2018:
A vaccine for type 1 diabetes developed by Finnish researchers will be tested on mainly Finnish human subjects in late 2018, researchers announced on Tuesday. The scientists first found that the prototype works effectively and safely on mice, and now say that the vaccine could be in mainstream use within eight years if the coming rounds of tests prove successful.
One skeptical reader asked us to check out the story.
Yle is Finland’s public broadcasting corporation (akin to NPR or the BBC). T he names of the lead researchers and their universities are real, the announcement of vaccine trials is real, and the story is true.
On 18 July 2017, the University of Tampere in Finland announced that Professor of Virology Heikki Hyöty and his team of researchers had identified a particular strand of enteroviruses (viruses transmitted through the intestines) linked to Type 1 diabetes, and developed a vaccine against them.
“Already now it is known that the vaccine is effective and safe on mice,” Hyöty said. “The developing process has now taken a significant leap forward as the next phase is to study the vaccine in humans.”
The university’s statement continued:
In the first clinical phase, the vaccine will be studied in a small group of adults to ensure the safety of the va Continue reading

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