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Bart Roep, Ph.D., Has Type 1 Diabetes Cure In His Sights

Bart Roep, Ph.D., Has Type 1 Diabetes Cure in His Sights

Bart Roep, Ph.D., Has Type 1 Diabetes Cure in His Sights


Bart Roep, Ph.D., Has Type 1 Diabetes Cure in His Sights
Bart O. Roep, Ph.D., has dedicated his life to the search for a cure for type 1 diabetes. And he thinks he is on the brink.
Roep, an internationally renowned immunologist who joined City of Hope last year from the Netherlands Leiden University Medical Center, was recently named the Chan Soon-Shiong Shapiro Distinguished Chair in Diabetes. He believes that this endowment and a $50 million funding project led by the Wanek family will be key in stopping the disease.
We need to do something in addition to treating the symptoms, Roep said. Diabetes has surpassed cancer as a cause of death. One of the goals of the diabetes program at City of Hope is to accelerate the progress against the disease. And the new $50-million grant is a catalyst to get there faster.
Instead of dealing with the effects of the disease, Roep is committed to treating the disease itself.
For 100 years, weve known how to deal with the symptoms, he said. Now, for the first time, we can tackle the cause. This is really one of the most exciting times since the discovery of insulin. We have the opportunity to offer a completely new generation of therapy to these patients.
After studying the mechanism of type 1 diabetes for the last two decades, Roep, the founding chair of the DepartmentofDiabetesImmunology within the Diabetes&MetabolismResearchInstituteatCityofHope , recently had his Eureka! moment when he realized that the disorder varies greatly from patient to patient.
One of the new insights is that diabetes is very diverse, he said. Based on Continue reading

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Kidney Cancer and Diabetes

Kidney Cancer and Diabetes


Is There a Link Between Kidney Cancer and Diabetes?
Evidence linking diabetes and kidney cancer has grown stronger over the past decade, leading researchers to investigate the reasons behind these links.
Kidney cancer is a disease in which kidney cells become cancerous and grow into a tumor.
Most kidney cancers are found before they spread to distant organs. Caught early , they can usually be treated successfully. Tumors can grow large if not detected.
This year, the American Cancer Society reports there will be at least 64,000 new cases of kidney cancer, affecting mostly men. Up to 15,000 people could die this year from this type of cancer.
Diabetes is a group of diseases resulting in high blood glucose (too much sugar in the blood). As of 2014, the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) reports 29.1 million people, or 9.3 percent of the U.S. population, have diabetes both diagnosed and undiagnosed.
Type 1 and type 2 diabetes are the two most common forms of diabetes, but there are other kinds, including one which occurs during pregnancy. Up to 95 percent of diabetics have type 2, according to NIDDK.
You are more likely to have type 2 if you are 45 or older, have a family history of diabetes, or are overweight and inactive. Other health problems, such as high blood pressure, also contribute to the development of type 2 diabetes.
Diabetes is just one of the many risk factors for kidney cancer. Obesity, smoking, high blood pressure, and family history are also potential risk factors, among others.
How diabetes is linked to kidney Continue reading

Deborah Greenwood discusses technology enabled diabetes self-management solutions

Deborah Greenwood discusses technology enabled diabetes self-management solutions


Deborah Greenwood discusses technology enabled diabetes self-management solutions
Posted on Jul 13, 2017 by Barbara Eichorst
Technologyis now part of a newscience within diabetes care. As diabetes educators, we are partnering with people with diabetes (PWD) to support their efforts in using the digital interventions. I am very excited about the first systematicreview of systemic reviews evaluating the existing evidence and best practicewhile using technology in diabetes care and education.Deborah Greenwood,PhD, RN, BC-ADM, CDE, FAADE Chief Digital Research Officer-Diabetes Mytonomy,is one of the authors of "A Systematic Review of Reviews Evaluating Technology-Enabled Diabetes Self-Management Education and Support" that was published recently. This month, I am happy to share my conversation with Deborah about diabetes and technology.
Deborah, how and why doyouhave an interestin technology as a CDE?
In my doctoral program, I focused all my elective courses in informatics and my independent study/internship opportunities in telehealth and diabetes. For my dissertation study, I conducted a randomized clinical trial using paired glucose checking in people with type 2 diabetes not on insulin supported by a technology-enabled remote monitoring system. The intervention group lowered A1C significantly more than the control group at 6 months. The study incorporated a complete feedback loop where PWD followed structured monitoring principles, shared their data with CDEs, were provided with feedback through the electronic health record and made behavior and medication changes. I Continue reading

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Type 2 diabetes and obesity induce similar transcriptional reprogramming in human myocytes

Abstract
Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity.
We generated and analyzed RNA-seq data from primary differentiated myotubes from 24 human subjects, using a factorial design (healthy/T2D and non-obese/obese), to determine the influence of each specific factor on genome-wide transcription. This setup enabled us to identify intrinsic properties, originating from muscle precursor cells and retained in the corresponding myocytes. Bioinformatic and statistical methods, including differential expression analysis, gene-set analysis, and metabolic network analysis, were used to characterize the different myocytes.
We found that the transcriptional program associated with obesity alone was strikingly similar to that induced specifically by T2D. We identified a candidate epigenetic mechanism, H3K27me3 histone methylation, mediating these transcriptional signatures. T2D and obesity were independently associated with dysregulated myogenesis, down-regulated muscle function, and up-regulation of inflammation and extracellular matrix components. Metabolic network analysis identified that in T2D but not obesity a specific metabolite subnetwork involved in sphingolipid metabolism was transcriptionally regulated.
Our findings identify inherent characteristics in myocytes, as Continue reading

How To Increase Insulin Sensitivity

How To Increase Insulin Sensitivity

Other than the fact that needing less insulin will save you tons of money, it also helps your overall health. The better your body is at using and processing insulin, the less you’ll need, and the more optimally your body will perform as a whole. Personally I saw the biggest improvements when I made the trifecta change: I went paleo, started eating low carb, and changed around my exercise routine. But all five of the tips below have helped increase insulin sensitivity and allowed me cut my insulin needs in half! Yes, half!
1. Go Paleo
The biggest reason for me to go paleo, even before I was diagnosed with Celiac disease, was because of the the Celiac + T1D connection. Type 1 diabetes and celiac disease share similar genes (DQ2 and DQ8) and are both immune-regulated. Typically type 1 diabetes is diagnosed first, even if you developed Celiac before developing T1D. Reason being because T1D symptoms are more obvious than Celiac symptoms especially because only 30% of people with Celiac have symptoms and on top of that celiac disease tends to be asymptomatic in type 1 diabetics (which it was for me).
Once I eliminated grain from my diet I figured I was already halfway to paleo so why not just take the plunge?! This switch, going from processed foods to real whole foods, was jaw dropping in regards to my insulin resistance. Now, even though I haven’t been able to find a solid study proving this, my own personal experience was all the proof I needed to turn me into a full blown Paleo enthusiast. My insulin responded better and my BG was more predictable which gave me more cont Continue reading

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