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A1 Beta-casein Milk Protein And Other Environmental Pre-disposing Factors For Type 1 Diabetes

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

A1 beta-casein milk protein and other environmental pre-disposing factors for type 1 diabetes

Globally type 1 diabetes incidence is increasing. It is widely accepted that the pathophysiology of type 1 diabetes is influenced by environmental factors in people with specific human leukocyte antigen haplotypes. We propose that a complex interplay between dietary triggers, permissive gut factors and potentially other influencing factors underpins disease progression. We present evidence that A1 β-casein cows’ milk protein is a primary causal trigger of type 1 diabetes in individuals with genetic risk factors. Permissive gut factors (for example, aberrant mucosal immunity), intervene by impacting the gut’s environment and the mucosal barrier. Various influencing factors (for example, breastfeeding duration, exposure to other dietary triggers and vitamin D) modify the impact of triggers and permissive gut factors on disease. The power of the dominant trigger and permissive gut factors on disease is influenced by timing, magnitude and/or duration of exposure. Within this framework, removal of a dominant dietary trigger may profoundly affect type 1 diabetes incidence. We present epidemiological, animal-based, in vitro and theoretical evidence for A1 β-casein and its β-casomorphin-7 derivative as dominant causal triggers of type 1 diabetes. The effects of ordinary milk containing A1 and A2 β-casein and milk containing only the A2 β-casein warrant comparison in prospective trials.
Type 1 diabetes, one of the most common chronic diseases among children,1 is characterised by the selective loss of insulin-producing pancreatic β-cells in genetically susceptible individua Continue reading

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'She's feeling terrible': Pregnant Danielle Lloyd 'has been forced to clear her schedule after being left bed-ridden with gestational diabetes'

'She's feeling terrible': Pregnant Danielle Lloyd 'has been forced to clear her schedule after being left bed-ridden with gestational diabetes'

She's been forced to scrap her work schedule for this week.
And it has now been revealed that Danielle Lloyd has reportedly been left bed-ridden with gestational diabetes and is feeling 'terrible'.
The 33-year-old star - who is expecting her fourth child, her first with her fiancé Michael O'Neill - is said to have been told to rest by her doctor.
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A source told The Sun Online: 'She’s been told by her doctor that she’s got to rest.
'Last night she wanted to make sure she could do her work commitments but her condition has left her feeling terrible and she’s laid up in bed.
'She’s feeling really bad. She doesn’t want to miss this but she has to.'
MailOnline has contacted Danielle's spokesperson for comment.
This comes after Danielle revealed she had been struck down with a mystery illness and was worrying about her health.
She shared in her OK! magazine column: 'I haven’t been very good at all this week. I’ve been feeling really poorly and I’ve had to go to the doctors twice because I don’t know what’s wrong with me.
'I know doctors tell you not to Google stuff but I did and I read about diabetes and how it can make you go into early labour and I was like, "Oh my God" it just makes you panic, I was quite frightened.'
Danielle looked radiant when she showed off her blossoming baby bump in a striking scarlet onsie in a cosy bedroom Instagram post on Monday.
The former glamour model was quite the stunning lady in red as she struck a pose caressing her tummy.
The crimson garment's plunging neckline teased her ample assets.
But she put the Continue reading

All About Dog Diabetes

All About Dog Diabetes

Diabetes is a chronic disease that impacts lots of mammals including humans and dogs. It occurs when the body’s ability to produce or respond to the hormone insulin is impaired.
Canine diabetes is incurable, but it’s a manageable disorder. With proper treatment, diabetic dogs can lead long, healthy, happy lives.
How does canine diabetes work?
The most common form of diabetes in dogs is diabetes mellitus, or “sugar diabetes.” As its name implies, sugar diabetes is a condition that affects your dog’s blood sugar level. A small organ near the stomach, the pancreas, is responsible for regulating blood sugar by producing insulin.
Here’s how it works: when your dog eats, her food is broken down into tiny components including carbohydrates. Carbs are then converted into simple sugars, including glucose. The pancreas releases insulin go help turn glucose to fuel inside your dog’s cells.
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If there’s not enough insulin available, glucose can’t get into cells. This can lead to a dangerously high glucose concentration in your dog’s bloodstream.
Two forms of dog diabetes
In a healthy dog, the pancreas produces insulin to moderate the sugar in their system. In a diabetic dog, the pancreas either can’t produce enough insulin, or the dog’s body can’t effectively use the insulin it does produce. These are the two forms of diabetes:
Insulin-deficiency diabetes: the most common type of canine diabetes. Occurs when the dog’s body doesn’t produce enough insulin. Dogs with insulin-deficiency diabetes need daily insulin shots to replace what their body c Continue reading

Confirmed Anew: Cow Milk May Trigger Type 1 Diabetes

Confirmed Anew: Cow Milk May Trigger Type 1 Diabetes

For quite some time the link between juvenile onset diabetes (type 1) and cow’s milk consumption has been noted in the scientific literature. You can view 12 such references on our page on Cow Milk. In genetically susceptible individuals the consumption of cow’s milk may trigger an autoimmune destruction of the beta cells in the pancreas which produce insulin. A new study, published in the journal Archives of Pediatric and Adolescent Medicine, has shed light on a possible new mechanism behind this connection.
Finish researchers looked at 1113 infants with a genetic susceptibility to type 1 diabetes and who were randomly assigned to receive one of three infant formulas during the first 6 months of life whenever breast milk was not available:
Cow’s milk formula (CMF)
Whey-based hydrolyzed formula (WHF)
Whey-based formula free of bovine insulin (insulin-free CMF)
Beta cell autoimmunity was monitored at ages 3,6, and 12 months and then annually until 3 years of age. The results were reported as follows:
In comparison with ordinary CMF, weaning to an insulin-free CMF reduced the cumulative incidence of autoantibodies by age 3 years in children at genetic risk of type 1 diabetes mellitus.
The likelihood of finding autoantibodies associated with beta cell autoimmunity was 25% lower in the whey-based hydrolyzed formula group, and 61% lower in the insulin-free whey-based formula when compared with the cow’s milk formula group.
Discussion
This study brings to the fore a serious problem associated with drinking the milk of another species. The protein composition within cow’ Continue reading

Celebrities With Diabetes Slideshow

Celebrities With Diabetes Slideshow

The Oscar-winning actor announced he has type 2 diabetes when late-night host David Letterman commented on his newly slim figure in October 2013. "I went to the doctor and he said, ‘You know those high blood sugar numbers you’ve been dealing with since you were 36? Well, you’ve graduated. You’ve got type 2 diabetes, young man.'" Hanks added that the condition is controllable, but he joked that he couldn't get back down to his high-school weight of 96 pounds. "I was a very skinny boy!"
The talk show host has type 2 diabetes. "It's definitely controllable," King has said on his show. Diabetes makes heart disease, stroke, kidney disease, and other serious health problems more likely. King has had bypass heart surgery. Diabetes wasn't the only thing that raised his risk for ticker trouble: King had been a heavy smoker, and smoking hurts the heart. But by taking care of his diabetes (and quitting smoking), King helps his ticker and the rest of his body.
Salma Hayek
The Oscar-nominee had gestational diabetes, which happens during pregnancy, while expecting her daughter, Valentina. Hayek has a family history of diabetes. Experts say all women should get checked for gestational diabetes when they are 24-28 weeks pregnant. Those at risk for type 2 diabetes are checked at their first prenatal visit. Gestational diabetes usually goes away after delivery, but it could return with a later pregnancy. It can also make you more likely to get type 2 diabetes later on.
This singer went public with his type 1 diabetes in 2007. He has said that his symptoms included weight loss and thi Continue reading

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