A Vaccine For Type 1 Diabetes Begins Human Trials In 2018

A Vaccine For Type 1 Diabetes Begins Human Trials in 2018

A prototype vaccine, decades in the making, that could prevent type 1 diabetes in children is ready to start clinical trials in 2018.
It's not a cure, and it won't eliminate the disease altogether, but the vaccine is expected to provide immunity against a virus that has been found to trigger the body's defences into attacking itself, potentially reducing the number of new diabetes cases each year.
Over two decades of research led by the University of Tampere in Finland has already provided solid evidence linking a type of virus called coxsackievirus B1 with an autoimmune reaction that causes the body to destroy cells in its own pancreas.
The type 1 form of diabetes – not to be confused with the more prevalent type 2 variety that tends to affect individuals later in life – is a decreased ability to produce the insulin used by the body's cells to absorb glucose out of the blood.
This loss of insulin is the result of pancreatic tissue called beta cells being destroyed by the body's own immune system, often within the first few years of life.
It's something of a mystery as to why the body identifies beta cells as foreign, though there could be a genetic link producing variations of human leukocyte markers, which act as the cell's 'ID tags'.
No doubt it's complex, and there are numerous ways this process can be triggered. One example established by virologist Heikki Hyöty from the University of Tampere is an infection by a type of enterovirus.
Enteroviruses are nasty pieces of work; you might be most familiar with polio, but they can also cause hand, foot and mouth disease, Continue reading

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CMAJ article links hunger in residential schools to Type 2 diabetes, obesity

Widespread, prolonged hunger that existed in residential schools is a contributing factor in the disproportionate health issues facing many Indigenous people, such as diabetes and obesity, according to an article published Monday in the Canadian Medical Association Journal.
"Hunger is really central to the experiences of residential school survivors," says Ian Mosby who co-authored the article with Tracy Galloway, both with the University of Toronto.
They say childhood malnutrition experienced in many government-funded schools is contributing to the higher risk for obesity, diabetes and heart disease among Indigenous people in adulthood.
"While this wasn't every single residential school," says Mosby, "it's common enough through survivor testimony that we need to start looking at hunger in residential schools as a real predictor of long-term health problems."
Residential schools across Canada faced significant underfunding, along with inadequate cooking facilities and untrained staff. Historians and former students have described children getting "one or two pieces of stale bread for lunch. Rarely getting meat, rarely getting milk and butter, and few fruits and vegetables," says Mosby.
He estimates many students received 1,000 to 1,400 calories a day. A normal range for a child's healthy development is 1,400 to 3,200.
Famine studies in China, Russia and the Netherlands show height-stunted youth developed greater insulin sensitivity and lower insulin levels, making them prone to developing Type 2 diabetes, the article notes.
That, paired with hormone changes from lack of foo Continue reading

A Vaccine For Type 1 Diabetes Begins Human Trials in 2018

A prototype vaccine, decades in the making, that could prevent type 1 diabetes in children is ready to start clinical trials in 2018.
It's not a cure, and it won't eliminate the disease altogether, but the vaccine is expected to provide immunity against a virus that has been found to trigger the body's defences into attacking itself, potentially reducing the number of new diabetes cases each year.
Over two decades of research led by the University of Tampere in Finland has already provided solid evidence linking a type of virus called coxsackievirus B1 with an autoimmune reaction that causes the body to destroy cells in its own pancreas.
The type 1 form of diabetes – not to be confused with the more prevalent type 2 variety that tends to affect individuals later in life – is a decreased ability to produce the insulin used by the body's cells to absorb glucose out of the blood.
This loss of insulin is the result of pancreatic tissue called beta cells being destroyed by the body's own immune system, often within the first few years of life.
It's something of a mystery as to why the body identifies beta cells as foreign, though there could be a genetic link producing variations of human leukocyte markers, which act as the cell's 'ID tags'.
No doubt it's complex, and there are numerous ways this process can be triggered. One example established by virologist Heikki Hyöty from the University of Tampere is an infection by a type of enterovirus.
Enteroviruses are nasty pieces of work; you might be most familiar with polio, but they can also cause hand, foot and mouth disease, Continue reading

Keeping Up With the Diabetes News

With the new year came a variety of diabetes-related news. First, reality show star Rob Kardashian was reportedly diagnosed with diabetes and hospitalized for diabetic ketoacidosis (DKA). We can’t confirm or deny the specifics of these reports or what type of diabetes Kardashian may have, but we did notice many medical inaccuracies in the news, which is unfortunately all too common in content written about diabetes. As always, our thoughts are with the Kardashians and the thousands of families who face a diabetes diagnosis every day.
And as of Jan. 1, American Girl dolls can be outfitted with their own diabetes care kits, complete with an insulin pump, glucose tablets, a log book and more—all items used by people to take care of their diabetes, especially when they must take insulin. We celebrate any efforts to embrace diabetes awareness and inclusion, especially if it helps young people with diabetes feel more understood and less alone.
Diabetes ought to be front-page news year-round; we need a robust national conversation to fuel the fight against America’s most urgent chronic health crisis. Diabetes, in all its forms, is a very serious disease. But while every headline shines a much-needed spotlight, it can also leave room for confusion about type 1 and type 2 diabetes.
The complexity of diabetes makes it ripe for myths and misinformation—so let’s get back to the basics. While there are certainly distinct differences between type 1 and type 2 diabetes, you may be surprised to learn how much they also have in common.
It starts with understanding the hormone insu Continue reading

An Apple Watch app is coming for people with diabetes

Medical device maker Dexcom has been showing off iPhone and Apple Watch integration for its implantable diabetes glucose monitors for the past few weeks. The app will display glucose readings on iOS devices and should be ready when Apple Watch is launched in April, according to the Wall Street Journal.
The Dexcom Apple Watch app, medical device experts say, is made possible by recent Food and Drug Administration policy changes that suggest the federal agency will only regulate medical hardware, and not the apps that connect it to consumer platforms like iOS and Android. The exact scenario of glucose monitoring for people with diabetes was discussed when Apple quietly met with FDA officials to discuss the possibility of Apple Watch triggering federal regulation.
People with diabetes and their loved ones want the kind of features that Dexcom’s iOS app promises. In fact, Dexcom’s app was preceded by NightScout, a open-source, not-for-profit, and unregulated set of tools created as a labor of love by software engineers around the world. NightScout takes readings from Dexcom glucose monitors, uploads them to the internet, and can display them on devices like the Pebble smartwatch.
Dexcom’s demos have only shown its Apple Watch app displaying glucose readings. There might be other features included, including alarms and calibration, but those haven’t been revealed yet.
The opportunity for Apple and device makers like Dexcom in mobile health is huge. Credit Suisse estimates there are 400 million people worldwide with Type II diabetes, with associated costs totaling up to $ Continue reading