A Type 1 Diabetes Pill? Newest Sotagliflozin Trial Results
Research reveals improved A1c and weight loss benefits for people with type 1 diabetes on sotagliflozin, but a slightly increased risk of DKA
The American Diabetes Association’s (ADA) 77th Scientific Session in June convened key leaders in diabetes research to share findings on the latest drug developments. At the conference, Lexicon Pharmaceuticals presented full results from three major trials looking at the safety and effectiveness of sotagliflozin, a new kind of type 1 diabetes therapy (a pill!) currently undergoing clinical trials that is taken in addition to insulin.
Two studies Lexicon presented at ADA (called inTandem1 and inTandem2) investigated how different doses of sotagliflozin affect measures such as A1c and weight. Trial participants either got 400 mg of sotagliflozin, 200 mg of sotagliflozin, or placebo (a “nothing” pill). A third study not presented at ADA (called inTandem3) compared 400 mg of sotagliflozin to placebo.
Results from inTandem1 found a significantly greater proportion of people taking sotagliflozin benefitted from the new therapy – defined as reducing A1c to less than 7% with no instances of severe hypoglycemia (low blood sugar) or diabetic ketoacidosis (known as DKA – read more about it here). Specifically:
44% of people taking 400 mg sotagliflozin benefitted, compared to 34% of those taking 200 mg of sotagliflozin and only 22% in the placebo group.
People taking 400 mg of sotagliflozin (the highest dose) lost an average of 6 pounds over 6 months, versus 3.5 pounds lost in those taking 200 mg of sotagliflozin and 1.8 pounds gained i Continue reading