A National Effort To Prevent Type 2 Diabetes: Participant-Level Evaluation Of CDC’s National Diabetes Prevention Program

A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDC’s National Diabetes Prevention Program

A National Effort to Prevent Type 2 Diabetes: Participant-Level Evaluation of CDC’s National Diabetes Prevention Program

OBJECTIVE To assess participant-level results from the first 4 years of implementation of the National Diabetes Prevention Program (National DPP), a national effort to prevent type 2 diabetes in those at risk through structured lifestyle change programs.
RESEARCH DESIGN AND METHODS Descriptive analysis was performed on data from 14,747 adults enrolled in year-long type 2 diabetes prevention programs during the period February 2012 through January 2016. Data on attendance, weight, and physical activity minutes were summarized and predictors of weight loss were examined using a mixed linear model. All analyses were performed using SAS 9.3.
RESULTS Participants attended a median of 14 sessions over an average of 172 days in the program (median 134 days). Overall, 35.5% achieved the 5% weight loss goal (average weight loss 4.2%, median 3.1%). Participants reported a weekly average of 152 min of physical activity (median 128 min), with 41.8% meeting the physical activity goal of 150 min per week. For every additional session attended and every 30 min of activity reported, participants lost 0.3% of body weight (P < 0.0001).
CONCLUSIONS During the first 4 years, the National DPP has achieved widespread implementation of the lifestyle change program to prevent type 2 diabetes, with promising early results. Greater duration and intensity of session attendance resulted in a higher percent of body weight loss overall and for subgroups. Focusing on retention may reduce disparities and improve overall program results. Further program expansion and investigation is needed to continue low Continue reading

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New medicine in UAE for diabetes

New medicine in UAE for diabetes

The UAE Ministry of Health and Prevention will introduce a new medicine for Type 2 diabetes which will be administered through a small titanium device the size of a matchstick that will be placed under the skin to dispense a daily dose for the diabetes patient for up to six months. The device will be available within the next 3 months.
Current data explains how similar class of medicines approved by the Food and Drug Administration in the US work: Type II diabetics tend to eat a little more than normal due to an impairment in the production of Glucagon Like Peptide I (GLP 1), a hormone produced in the small intestine which sends the signal of fullness to the brain and also sends a signal for the pancreas to release insulin after a meal. However, in diabetics, the small intestine does not produce enough GLP I and there is a delayed signal of satiety resulting in obesity which in turn leads to diabetes.
These class of medicines release GLP I for six months as per the patient’s requirement so that he eats less and thereby has better blood sugar control. But the patient will require to take his regular medication or insulin injection along with it.
Over the last decade, pharmaceutical firms have come out with earlier versions of GLP I. The first came out 10-15 years ago under the brand name Byetta and contained a version of GLP I called Exenatide which was required to be taken twice daily. Five years ago, another version was produced under the brand name Victoza containing Liraglutide was introduced that was required to be taken once daily. In 2014. The GLP I Dulagluti Continue reading

Potato Consumption and Risk of Type 2 Diabetes: Results From Three Prospective Cohort Studies

Potato Consumption and Risk of Type 2 Diabetes: Results From Three Prospective Cohort Studies

OBJECTIVE We aimed to elucidate whether potato consumption is associated with a higher risk of type 2 diabetes (T2D).
RESEARCH DESIGN AND METHODS We analyzed data in three cohorts consisting of U.S. male and female health professionals without diabetes, cardiovascular disease, and cancer at baseline: 70,773 women from the Nurses’ Health Study (1984–2010), 87,739 women from Nurses’ Health Study II (1991–2011), and 40,669 men from the Health Professionals Follow-up Study (1986–2010). Potato consumption was assessed quadrennially using validated food frequency questionnaires (FFQs), and we calculated 4-year change in potato consumption from consecutive FFQs. Self-reported T2D diagnosis was confirmed using a validated supplementary questionnaire.
RESULTS During 3,988,007 person-years of follow-up, 15,362 new cases of T2D were identified. Higher consumption of total potatoes (including baked, boiled, or mashed potatoes and french fries) was significantly associated with an elevated risk for T2D: the pooled hazard ratio (HR) of T2D compared with <1 serving/week was 1.07 (95% CI 0.97–1.18) for 2–4 servings/week and 1.33 (95% CI 1.17–1.52) for ≥7 servings/week after adjustment for demographic, lifestyle, and dietary factors. In addition, the pooled HRs of T2D for every 3 servings/week were 1.04 (95% CI 1.01–1.08) for baked, boiled, or mashed potatoes, and 1.19 (95% CI 1.13–1.25) for french fries. We further estimated that the HR of T2D was 0.88 (95% CI 0.84–0.91) for replacing 3 servings/week of total potatoes with the same amount of whole grains. Last, in c Continue reading

Vitamin D and Its Role in Diabetes

Vitamin D and Its Role in Diabetes

Vitamin D, otherwise known as the “sunshine vitamin,” is vital for bone health but may soon be regarded as an important marker of health similar to cholesterol and blood pressure. Over the last few decades, scientists have looked past the skeletal support this micronutrient offers and are discovering that vitamin D may play a vital role in insulin, glucose, and inflammation regulation as well as potentially being a warning sign for different cardiovascular and endocrine diseases — including type 2 diabetes.
So What Exactly Is Vitamin D?
Vitamins are chemicals the body needs to function properly and are required to maintain good health. There are two main categories of vitamins: water soluble and fat soluble vitamins.
Fat Soluble Vitamins
Water Soluble Vitamins
Vitamin A (retinol)
B1 Thiamine
B7 Biotin
Vitamin D
B2 Riboflavin
B9 Folate
Vitamin E
B3 Naicin
B12 Cobalamin
B5 Pantothenic acid
C Ascorbic acid
B6 Pyridoxine
As seen in the table above, water-soluble vitamins like vitamin B and vitamin C are generally excreted and can be replenished daily with little to no worry about toxicity for most people. Fat-soluble vitamins like vitamin D are stored in the liver and fatty tissue and are not always required daily by everyone (depending on your nutritional status).
Excessive amounts of vitamin D and other fat-soluble vitamins can be toxic, but being deficient in one of these vitamins can cause numerous other health problems as well.
Vitamin D is unlike any other micronutrient in that the body can produce its own from sunlight whereas most other vitamins are acquired by Continue reading

Entrepreneurs are wearing implants made for diabetes in the pursuit of 'human enhancement'

Entrepreneurs are wearing implants made for diabetes in the pursuit of 'human enhancement'

In a photo posted to Instagram earlier this year, Dave Asprey, founder and CEO of Bulletproof Coffee, smiles big as he flexes his left arm, revealing a small white disk attached to this tricep.
"It's official. I'm a cyborg," the caption reads.
In Silicon Valley, a growing number of entrepreneurs and biohackers are using a medical technology called a continuous glucose monitor, or CGM, in order to learn more about how their bodies work. They wear the device under their skin for weeks at a time.
CGMs, which cropped up on the market less than 10 years ago and became popular in the last few years, are typically prescribed by doctors to patients living with diabetes (both types 1 and 2). They test glucose level, or the amount of sugar in a person's blood, and send real-time results to a phone or tablet. Unlike fingerstick tests, CGMs collect data passively, painlessly, and often.
For people taking a DIY approach to biology, CGMs offer a way to quantify the results of at-home experiments around fasting, exercise, stress, and sleep.
A patient checks their blood glucose level using a conventional fingerstick test. Stoyan Nenov/Reuters
Asprey, a self-proclaimed biohacker who's spent over $1 million on "smart drugs," wearable tracking devices, and diagnostics tests in the pursuit of cognitive enhancement, has been wearing a CGM on and off for two months. He does not have diabetes, though he's familiar with fingerstick tests from 20 years ago when he weighed 300 pounds and was told by his doctor to monitor his glucose.
In 2017, Asprey bought the device from a European vendor online. ( Continue reading

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