diabetestalk.net

A Different Kind Of Diabetes

A Different Kind of Diabetes

A Different Kind of Diabetes


*Disclaimer: the following is a post featuring my opinions and research Ive done. Im not a medical professional or any kind of professional. Well, Im really good at blankly staring off in the distance. Does that count?
I recently came across an AP news report on IV bars, and how seemingly healthy people use them for a number of reasons. They interviewed one woman who goes in for an IV every time her Lyme disease symptoms flare up. She said it helps her to function while her symptoms are worse. Another person, a man I guessed to be in his late-twenties, said getting IV hydration cures his hangover within 30 minutes its like he never went out partying the night before.
This story immediately resonated with me because I go out partying pretty much every night and can never kick my hangover the next day. Just joking. But seriously, it resonated with me for a couple reasons: (1.) because MECFS often makes me feel hungover, or much worse, if I dont get IV hydration everyday, or at least twice a week, and the feeling is usually worse if I overexert myself. But also, the story resonated with me because (2.) Ive been getting IV saline (and sometimes vitamins) for a year now and, within that time, Ive gone from aphonic, eating through straws, and unable to elevate my body, to now consistently improving with every infusion.
I dont want to come off as sanctimonious pushing IV treatments on anyone. Everybody has a different body, and some people have different reactions to treatment, so whether you are healthy or have MECFS, Lyme disease, or another condition, IV hydration may no Continue reading

Rate this article
Total 1 ratings
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8

International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8


Home / Resources / Clinical Gems / International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8
International Textbook of Diabetes Mellitus, 4th Ed., Excerpt #59: Mechanisms of insulin signal transduction Part 3 of 8
Following insulin binding and receptor autophosphorylation, the next committed step in signal transduction is tyrosine phosphorylation of intracellular proteins. To accomplish this, autophosphorylation of the subunit mediates noncovalent but stable interactions between the receptor and intracellular substrate proteins, and this positions these molecules for tyrosine phosphorylation by the activated insulin receptor kinase [26 28]. Several proteins are rapidly phosphorylated on tyrosine residues by ligand-bound insulin receptors, including six insulin receptor substrate proteins (IRS-1, IRS-2, IRS-3, IRS-4, IRS-5, IRS-6) [29 33], Src-homology-collagen proteins (SHC) [34] and, growth factor receptor bound-2 (Grb2) associated binder-1 (Gab-1) [35], signal-regulatory protein (SIRP) family members [36,37], the CAP/c-Cbl complex [38,39], an adapter protein with a PH and SH2 domain (APS) [40], signal transducer and activator of transcription 5B (STAT5B) [41], and proteins referred to as downstream of kinase (DOK 1-6) [33,42].
There is no known enzymatic activity associated with insulin receptor substrate molecules; however, their primary structure is noteworthy for multiple sites capable of interaction with other proteins. The receptor substrates are characterized by a representative architecture, par Continue reading

Sexual Health - Women - Diabetes Can't Stop Me!

Sexual Health - Women - Diabetes Can't Stop Me!


Diabetes affects many aspects of your physical and mental health. Sexual health is something that can be difficult to talk about and often people suffer in silence. However itis very important that you do talk to someone about any sexual health problems or difficulties, as there are things that can help prevent and manage any issues. Most importantly these problems can affect relationships, and as your partner is vital to your overall wellbeing, any issues need to be discussed and sorted out so you can feel united in your relationship and your lives.
Diabetes can affect both men and womens sexual health. This page will give some information about womens sexual health. You can find out more about mens sexual health here.
Many women with diabetes experience sexual problems although this is not often talked about. Research about sexual problems in women with diabetes is limited one study found 27 percent of women with type 1 diabetes experienced sexual dysfunction. Another study found 18 percent of women with type 1 diabetes and 42 percent of women with type 2 diabetes experienced sexual health problems.
Sexual problems for women with diabetes may include:
decreased vaginal lubrication, resulting in vaginal dryness
uncomfortable or painful sexual intercourse
decreased or no desire for sexual activity
Causes of sexual problems in women with diabetes include nerve damage, reduced blood flow to genital and vaginal tissues, and hormonal changes. Other possible causes include some medications, alcohol abuse, smoking, psychological problems such as anxiety or depression, Continue reading

Making Diabetes Self-Management Education Patient-Centered: Results From a North Carolina Program

Making Diabetes Self-Management Education Patient-Centered: Results From a North Carolina Program


Evidence-Based Diabetes Management > March 2017 Published on: March 05, 2017
Making Diabetes Self-Management Education Patient-Centered: Results From a North Carolina Program
How tailoring a diabetes self-management program to patients' cultural and individual needs brought success.
At present in the United States, 29 million individuals have diabetes1 and 86 million have prediabetes, and the CDC estimates that 9 of every 10 persons with prediabetes are unaware of the condition.2 The annual financial toll of the disease is $245 billion in healthcare and lost productivity costs, according to the American Diabetes Association (ADA).3
How can we change these statistics? Based on my experiences as a nurse and diabetes educator, we will not be effective in fighting the nations diabetes epidemic without more foot soldiers in the trenches alongside our patients. Its during this day-to-day work that we, as diabetes educators, spend time with our patientsevaluating them and encouraging them. Once we understand the daily barriers to success, we can make adjustments for when life happens.
In October 2014, Northwest Medical Partners of Mount Airy, North Carolina, created a Diabetic Center of Excellence. (The practice has since joined Northern Family Medicine of Surry County.4) From inception, this center was designed to produce measurable and reportable patient outcomes and, when possible, to reduce the amount of medication patients needed while improving glycated hemoglobin (A1C) levels.5 The overall goal of this program is to equip each patient with the resources, tools, and Continue reading

Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes

Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes


Untargeted metabolomic analysis in naturally occurring canine diabetes mellitus identifies similarities to human Type 1 Diabetes
Scientific Reports volume7, Articlenumber:9467 (2017) Cite this article
While predominant as a disease entity, knowledge voids exist regarding the pathogenesis of canine diabetes. To test the hypothesis that diabetic dogs have similar metabolomic perturbations to humans with type 1 diabetes (T1D), we analyzed serum metabolomic profiles of breed- and body weight-matched, diabetic (n = 6) and healthy (n = 6) dogs by liquid chromatography-mass spectrometry (LC-MS) profiling. We report distinct clustering of diabetic and control groups based on heat map analysis of known and unknown metabolites. Random forest classification identified 5/6 dogs per group correctly with overall out of bag error rate = 16.7%. Diabetic dogs demonstrated significant upregulation of glycolysis/gluconeogenesis intermediates (e.g., glucose/fructose, C6H12O6, keto-hexose, deoxy-hexose, (P < 0.01)), with significant downregulation of tryptophan metabolism metabolites (e.g., picolinic acid, indoxyl sulfate, anthranilate, (P < 0.01)). Multiple amino acids (AA), AA metabolites, and bile acids were also significantly lower in diabetic versus healthy dogs (P < 0.05) with the exception of the branched chain AA valine, which was elevated in diabetic animals (P < 0.05). Metabolomic profiles in diabetic versus healthy dogs shared similarities with those reported in human T1D (e.g., alterations in glycolysis/gluconeogensis metabolites, bile acids, and elevated branched chain AA). Fur Continue reading

No more pages to load

Popular Articles

  • Diabetes Awareness Month: Why is it so important to take your diabetes medication?

    As we mark Diabetes Awareness Month in November, it is perhaps good to start with a reality check. The fact is that too many Canadians are already very aware of diabetes, either because they are living with it, or know at least one friend or family member who is. The latest Statistics Canada data (from 2016) show that about 2.1 million Canadians have been diagnosed with diabetes (7% of the populat ...

  • Glaucoma And Diabetes: Can Diabetes Affect Your Eyes?

    People with diabetes are twice as likely to be at risk of having glaucoma compared to people without diabetes. We will first look at how the eye works, what glaucoma is, followed by the relationship between glaucoma and diabetes. Clara’s story Clara’s eyes were feeling tired all of the time. She was attributing the tiredness to her Type 2 diabetes, but she wasn’t too sure about it. That’s ...

  • Diabetes Complications in Dogs and Cats: Diabetes Ketoacidosis (DKA)

    Unfortunately, we veterinarians are seeing an increased prevalence of diabetes mellitus in dogs and cats. This is likely due to the growing prevalence of obesity (secondary to inactive lifestyle, a high carbohydrate diet, lack of exercise, etc.). So, if you just had a dog or cat diagnosed with diabetes mellitus, what do you do? First, we encourage you to take a look at these articles for an explan ...

  • Half Of Adults In The U.S. Have Diabetes Or Pre-Diabetes, Study Finds

    A national wake up call to intensify efforts to control the obesity crisis with added focus on diet, exercise and monitoring blood sugar According to a study published online in JAMA today, nearly 50% of adults living in the U.S. have diabetes or pre-diabetes, a condition where a person already has elevated blood sugar and is at risk to develop diabetes. Diabetes, a condition where blood sugar is ...

  • Diabetes in Dogs (Diabetes Mellitus)

    Diabetes in dogs is a common disorder and is similar to juvenile diabetes in people in which the pancreas cannot produce sufficient amount of insulin. This page looks at the symptoms, health risks, and treatment of this disease. It also discusses how to use some natural remedies such as herbs and supplements to help dogs with diabetes. Diabetes mellitus (sugar diabetes) is a common autoimmune diso ...

  • American Diabetes Month – Is Type 2 Diabetes Reversible?

    Diabetes has become one of the largest medical issues of our time. According to CDC statistics given in January 2014, an estimated 29.1 million adults and adolescence living in the United States have diabetes. Of that number, 7.2 million are not even aware they have it. Roughly 5% of all diabetic cases fall into the category of Type 1 with the remaining majority being Type 2. The primary differenc ...

  • World Diabetes Day: 5 Top Food Myths Around Diabetes Revealed

    Its the World Diabetes Day today! The day which was initiated by International Diabetes Federation to spread awareness and promote better diabetes management amongst people who have been suffering from the condition. Diabetes is a group of metabolic diseases characterized by high blood sugar either because of the inability of the body to produce enough insulin or the inability to respond to the in ...

  • Say Goodbye To Diabetes With These Amazing Home Remedies For Diabetes

    Many common herbs and spices are claimed to have blood sugar lowering effects, it is often argued that use of natural therapies could reduce blood sugars. Read on to know about the home remedies for diabetes. 35 Shares Diabetes is a widespread and persistent problem and India, which is why India is called the world capital of diabetes. In general, there are two main types of diabetes - type 1 diab ...

  • Symptoms of EARLY diabetes: Five risk factors putting YOU on course for type 2 diabetes

    Prediabetes is also referred to by medics as borderline diabetes, is a metabolic condition. If undiagnosed or untreated, prediabetes can develop into type 2 diabetes; which is treatable but not easily reversed. Experts said it is a ‘critical stage’ in the development of diabetes because lifestyle choices - such as changing diet and exercising - can return blood sugar levels to normal. It is th ...

Related Articles