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Why Ketone Bodies Are Produced In The Body?

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In this video, Team Sugardaddies demonstrates what the SD glucometer circuit reads for a glucose solution in comparison to the generated controlled reading of 116mg/dL by the biochem analyzer.

Wvsom -- Biochem

Ketone Bodies are produced in the ________ Flashcards Matching Hangman Crossword Type In Quiz Test StudyStack Study Table Bug Match Hungry Bug Unscramble Chopped Targets Oxidation of Ketone Bodies Question Answer Ketone Bodies are produced in the ________ Liver Is ketone body production a fed state or a fasted state event? Fasted State Are ketones toxic? Not as long as they can be used. Why is ketone body production and use in a fasted state? Liver Beta oxidizes esxcess fatty acids mobilized from adipocytes in teh fasted state. Acetyl-CoA produced by B oxidation is the "excess" carbon for hepatic ketone body synthesis What produces Acetyl CoA for ketone production? B-Oxidation and ketogenic amino acid catabolism Why can't the liver use all the acetyl CoA it produces in the fasted state? B-oxidation produces more Aceytl CoA than can be used Why can't the liver use all of the acetyl CoA it produces in the Fasted Stated The liver must devote significant oxaloacetate to gluconeogenesis so this limites the TCA cycle activity. What does teh liver obtain from its B-oxidation of excess fatty acids? FADH2 AND NADH are used by the liver without involvement of teh TCA cycle. Can go straight t Continue reading >>

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Popular Questions

  1. yjj8817

    Why is it that liver goes through all the trouble of making ketone bodies from acetyl coa when the ketone bodies are converted back to acetyl coa in the other tissues?

  2. desertrat12

    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation

  3. yjj8817

    desertrat12 said: ↑
    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation
    But by converting acetyl coa that was provided by fatty acid to ketone bodies and shipping them out to other tissues, aren't you depleting coa?
    Am I missing something?

  4. -> Continue reading
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Fatty acid oxidation lecture - This biochemistry lecture explains the process of beta oxidation of fatty acids. This lectures explains the beta oxidation process of fatty acids step by step. beta-oxidationis the catabolic process by whichfatty acidmolecules are broken down in the cytosol in prokaryotes and in the mitochondria in eukaryotes to generate acetyl-CoA, which enters the citricacidcycle, and NADH and FADH2, which are co-enzymes used in the electron transport to generate ATP molecules. Beta oxidationof fatty acids takes place in the mitochondrial matrix for the most part. However, fatty acids have to be activated for degradation by coenzyme A by forming a fatty acyl-CoA thioester. For short and medium length fatty acids, they undergo this reaction in the mitochondria. When pancreatic lipase acts on the small lipid droplets, it breaks them down into freefatty acidsand monoglycerides, which are the two digestive products of lipids. These small units are able to pass through the intestinal mucosa and enter the epithelial cells of the small intestine. Where are fatty acids stored in the body? Fatty acidsare released, between meals, from the fat depots in adipose tissue, where t

Fatty Acid Oxidation, Ketone Body Production

Sort Draw a simple diagram linking glycolysis, the TCA cycle, triglyceride breakdown and triglyceride synthesis as seen in the liver. Include some of the major substrates, intermediates, and products such as glycerol, DHAP, fatty acyl CoA, malonyl CoA and acetyl CoA. (be able to do this...) Outline the 4 steps involved in the synthesis of triglycerides from glycerol-3-phosphate and activated fatty acids. 1 fatty acid, linked to Acetyl-CoA, is added to glycerol-3-phosphate via an acyltransferase enzyme. The product here is a glycerol backbone with one R group attached (lysophosphatidic acid). Another fatty acid is added to lysophophatidic acid via a different acyltransferase enzyme, creating a molecule with a glycerol backbone and two fatty acids (phosphatidic acid). The phosphate group remaining on the final carbon of the glycerol backbone is removed by a phosphatase enzyme (making diacylglycerol), in order for... The third and final fatty acid to be added by a third acyltransferase enzyme, creating the end triacylglycerol product. Describe how fatty acids are mobilized from adipose tissue. Triacylglycerols are stored in adipocytes (fat storage cells). When fatty acids are needed b Continue reading >>

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Popular Questions

  1. yjj8817

    Why is it that liver goes through all the trouble of making ketone bodies from acetyl coa when the ketone bodies are converted back to acetyl coa in the other tissues?

  2. desertrat12

    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation

  3. yjj8817

    desertrat12 said: ↑
    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation
    But by converting acetyl coa that was provided by fatty acid to ketone bodies and shipping them out to other tissues, aren't you depleting coa?
    Am I missing something?

  4. -> Continue reading
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Moof's Medical Biochemistry Video Course: http://moof-university.thinkific.com/... In this video, I describe how Ketone Bodies are oxidized for energy. The liver makes ketone bodies that travel through the blood to extrahepatic tissues, where they are oxidized in the mitochondrial matrix to give energy. The pathway begins with D--Hydroxybutyrate, as it is oxidized to Acetoacetate by the same D--Hydroxybutyrate Dehydrogenase reaction (except in reverse). The Acetoacetate is then activated to Acetoacetyl-CoA by -Ketoacyl-CoA Transferase (also known as Thiophorase); this second step takes a Coenzyme A from Succinyl-CoA (an intermediate of the Krebs Cycle). The Acetoacetyl-CoA is then cleaved into two Acetyl-CoA molecules that can go through the Krebs Cycle to be oxidized, resulting in energy that cell can use. Ultimately, the liver is basically sending Acetyl-CoA that it isnt metabolizing to other tissues (by way of Ketone Bodies in the blood) so that those other tissues can utilize the Acetyl-CoA. However, sometimes, the extrahepatic tissues do not oxidize the ketone bodies rapidly enough to keep up with the pace at which they are arriving from the blood. This is a problem described

Ketone Bodies As Signaling Metabolites

Outline of ketone body metabolism and regulation. The key irreversible step in ketogenesis is synthesis of 3-hydroxy-3-methylglutaryl-CoA by HMGCS2. Conversely, the rate limiting step in ketolysis is conversion of acetoacetate to acetoacetyl-CoA by OXCT1. HMGCS2 transcription is heavily regulated by FOXA2, mTOR, PPARα, and FGF21. HMGCS2 activity is post-translationally regulated by succinylation and acetylation/SIRT3 deacetylation. Other enzymes are regulated by cofactor availability (e.g., NAD/NADH2 ratio for BDH1). All enzymes involved in ketogenesis are acetylated and contain SIRT3 deacetylation targets, but the functional significance of this is unclear other than for HMGCS2. Although ketone bodies are thought to diffuse across most plasma membranes, the transporter SLC16A6 may be required for liver export, whereas several monocarboxylic acid transporters assist with transport across the blood–brain barrier. Abbreviations: BDH1, β-hydroxybutyrate dehydrogenase; FGF21, fibroblast growth factor 21; FOXA2, forkhead box A2; HMGCS2, 3-hydroxy-3-methylglutaryl (HMG)-CoA synthase 2; HMGCL, HMG-CoA lyase; MCT1/2, monocarboxylic acid transporters 1/2; mTOR, mechanistic target of rap Continue reading >>

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Popular Questions

  1. yjj8817

    Why is it that liver goes through all the trouble of making ketone bodies from acetyl coa when the ketone bodies are converted back to acetyl coa in the other tissues?

  2. desertrat12

    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation

  3. yjj8817

    desertrat12 said: ↑
    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation
    But by converting acetyl coa that was provided by fatty acid to ketone bodies and shipping them out to other tissues, aren't you depleting coa?
    Am I missing something?

  4. -> Continue reading
read more

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