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Why Ketone Bodies Are Produced In The Body?

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Ketogenesis

What is Ketogenesis? Ketogenesis (1, 2) is a biochemical process that produces ketone bodies by breaking down fatty acids and ketogenic amino acids. The process supplies the needed energy of certain organs, especially the brain. Not having enough ketogenesis could result to hypoglycaemia and over production of ketone bodies leading to a condition called ketoacidosis. It releases ketones when fat is broken down for energy. There are many ways to release ketones such as through urination and exhaling acetone. Ketones have sweet smell on the breath. (3) Ketogenesis and ketoacidosis are entirely different thing. Ketoacidosis is associated with diabetes and alcoholism, which could lead to even serious condition like kidney failure and even death. Picture 1 : Ketogenic pathway Photo Source : medchrome.com Image 2 : A pyramid of ketogenic diet Photo Source : www.healthline.com What are Ketone bodies? Ketone bodies are water soluble molecules produced by the liver from fatty acids during low food intake or fasting. They are also formed when the body experienced starvation, carbohydrate restrictive diet, and prolonged intense exercises. It is also possible in people with diabetes mellitus t Continue reading >>

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Popular Questions

  1. yjj8817

    Why is it that liver goes through all the trouble of making ketone bodies from acetyl coa when the ketone bodies are converted back to acetyl coa in the other tissues?

  2. desertrat12

    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation

  3. yjj8817

    desertrat12 said: ↑
    Ketones are made when glucose stores are low, then, like you said, ketone bodies can be used by some non liver tissues to make acetyl coA and thus go on to make some atp. However, if glucose stores are low then the liver will turn to beta oxidation to make energy. Fatty acids go through beta oxidation and one of the products is acetyl coA. In order to go through beta oxidation, there needs to be coA avaliable. If the liver made acetyl coA and kept shipping it out the supply of coA would deplete, and the whole point to produce energy without glucose would be harmed due to a lack of coA for beta oxidation
    But by converting acetyl coa that was provided by fatty acid to ketone bodies and shipping them out to other tissues, aren't you depleting coa?
    Am I missing something?

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