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Why Is Dka Metabolic Acidosis

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Acid–base Problems In Diabetic Ketoacidosis

Disclosure forms provided by the authors are available with the full text of this article at NEJM.org. Dr. Halperin reports holding a patent on the use of sodium-linked glucose transporter 2 inhibitors to increase the excretion of water in patients with hyponatremia (US 8,518,895,B2) and a pending patent application on the use of sodium-linked glucose transporter 2 inhibitors to increase urine volume and lower solute concentration in the urine (08578 11286 PSP). No other potential conflict of interest relevant to this article was reported. We thank Drs. Arlan Rosenbloom, Brian Robinson, and Robert Jungas for their critique and helpful suggestions in the preparation of an earlier version of the manuscript, and S.Y. Lee for secretarial assistance. From the Renal Division, St. Michael’s Hospital and University of Toronto, and Keenan Research Center, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, University of Toronto, Toronto. Address reprint requests to Dr. Halperin at the Department of Medicine, University of Toronto Keenan Research Center, Li Ka Shing Knowledge Institute of St. Michael’s Hospital, 30 Bond St., Rm. 408, Toronto, ON M5B 1W8, Canada, or at mitchell.h Continue reading >>

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  1. Paraish Misra

    This side effect was very common with phenformin (metformin’s “parent drug”), and in fact led to its withdrawal from many markets. However, lactic acidosis appears to be very uncommon with metformin. In fact, whether or not lactic acidosis occurs at all with metformin is a matter of intense debate among some physicians. Nonetheless, out of safety, physicians will not prescribe metformin to patients at high risk of lactic acidosis (such as patients with advanced kidney disease).

  2. George Johnson

    This answer is not a substitute for professional medical advic...

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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Haemofiltration As A Treatment Option In Refractory Life-threatening Diabetic Ketoacidosis

Background: Treating life-threatening diabetic ketoacidosis (DKA) with a pH of <6.9 is extremely challenging and often refractory to treatment using standard fixed dose insulin DKA management protocols which may not work effectively at this low pH because of increased insulin resistance. I.v. bicarbonate (HCO3) use in this situation can be considered but remains controversial due to the risk of significant side effects as well as limited evidence in literature. Here we attempt to describe a case of fulminant DKA without renal failure, where treatment with haemofiltration (HF) for severe metabolic acidosis was successful. Case history: A 23-year-old female with history of recurrent episodes of DKA and poor diabetes control secondary to non-compliance, presented to the emergency department via ambulance after being found collapsed and had successful cardiopulmonary resuscitation for pulseless electrical activity and was subsequently treated with standard DKA protocol. Investigations on admission: pH 6.752, HCO3 1.3, lactate 3.1, base excess −30, blood glucose 45 mmol/l, blood ketones 6 mmol/l, creatinine 133 mmol, urea 10.8 mmol, and eGFR 43. Treatment: Despite maximal DKA treatmen Continue reading >>

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  1. Nathaniel Teng

    Metabolic Acidosis

    Hyperkalemia

    Medicine and Healthcare



    What are hyperkalemia and metabolic acidosis?




    1 Answer







    Hyperkalemia = high potassium levels in the blood. Commonly due to renal failure- kidneys not able to get rid of potassium so it builds up in your body. Hyperkalemia can be fatal because it causes heart arrhythmias including ventricular fibrillation.

    Metabolic acidosis is also a result of renal failure and is due to the kidneys not being able to excrete enough acid. Normally the pH of your blood is 7.35–7.45, so anything below 7.35 is considered ‘acidosis'. Metabolic in this case simply means caused by the kidneys, as opposed to ‘respiratory' acidosis which is due to airway obstruction and not being able to breathe out enough CO2

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Mechanism Of Normochloremic And Hyperchloremic Acidosis In Diabetic Ketoacidosis

Oh M.S. · Carroll H.J. · Uribarri J. Man S. Oh, MD, Department of Medicine, State University of New York, Health Science Center at Brooklyn, Brooklyn, NY 11203 (USA) Continue reading >>

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  1. Paraish Misra

    This side effect was very common with phenformin (metformin’s “parent drug”), and in fact led to its withdrawal from many markets. However, lactic acidosis appears to be very uncommon with metformin. In fact, whether or not lactic acidosis occurs at all with metformin is a matter of intense debate among some physicians. Nonetheless, out of safety, physicians will not prescribe metformin to patients at high risk of lactic acidosis (such as patients with advanced kidney disease).

  2. George Johnson

    This answer is not a substitute for professional medical advic...

  3. -> Continue reading
read more

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  • Why Is Dka Metabolic Acidosis

    Background: Treating life-threatening diabetic ketoacidosis (DKA) with a pH of <6.9 is extremely challenging and often refractory to treatment using standard fixed dose insulin DKA management protocols which may not work effectively at this low pH because of increased insulin resistance. I.v. bicarbonate (HCO3) use in this situation can be considered but remains controversial due to the risk of significant side effects as well as limited evidence ...

    ketosis Mar 31, 2018
  • Is Dka Metabolic Or Respiratory Acidosis?

    Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus.[1] Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness.[1] A person's breath may develop a specific smell.[1] Onset of symptoms is usually rapid.[1] In some cases people may not realize they previously had diabetes.[1] DKA happens most often i ...

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    Diabetic ketoacidosis is an acute metabolic complication of diabetes characterized by hyperglycemia, hyperketonemia, and metabolic acidosis. Hyperglycemia causes an osmotic diuresis with significant fluid and electrolyte loss. DKA occurs mostly in type 1 diabetes mellitus (DM). It causes nausea, vomiting, and abdominal pain and can progress to cerebral edema, coma, and death. DKA is diagnosed by detection of hyperketonemia and anion gap metabolic ...

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