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Why Is Bicarb Low In Dka

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Diabetic Ketoacidosis

© 1996–2017 themedicalbiochemistrypage.org, LLC | info @ themedicalbiochemistrypage.org Definition of Diabetic Ketoacidosis The most severe and life threatening complication of poorly controlled type 1 diabetes is diabetic ketoacidosis (DKA). DKA is characterized by metabolic acidosis, hyperglycemia and hyperketonemia. Diagnosis of DKA is accomplished by detection of hyperketonemia and metabolic acidosis (as measured by the anion gap) in the presence of hyperglycemia. The anion gap refers to the difference between the concentration of cations other than sodium and the concentration of anions other than chloride and bicarbonate. The anion gap therefore, represents an artificial assessment of the unmeasured ions in plasma. Calculation of the anion gap involves sodium (Na+), chloride (Cl–) and bicarbonate (HCO3–) measurements and it is defined as [Na+ – (Cl– + HCO3–)] where the sodium and chloride concentrations are measured as mEq/L and the bicarbonate concentration is mmol/L. The anion gap will increase when the concentration of plasma K+, Ca2+, or Mg2+ is decreased, when organic ions such as lactate are increased (or foreign anions accumulate), or when the concentratio Continue reading >>

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Popular Questions

  1. flowerlady

    Since in DKA we have acidosis why there is decrease in HCO3 bicarbonate
    and why there is hyperkalemia if there is osmotic diuresis?

  2. step_enhancer

    usually when there is acidosis H+ goes into the cell and K+ comes out of the cell resulting in the hyperkalemia but intracellular hypokalemia.
    H+/K+ pump is present on the surface of the cells.
    pts with diabetic ketoacidosis have intracellular hypokalemia ,so they r given glucose,insulin and K+ to normalize their intracellular K+ to prevent arrhythmias.

  3. tiger73jo

    In DKA there is gain of fixed acids (ketone bodies ) causes excess (H+) ,
    and since there should be an equilibrium in the reaction (CO2) <--> (H+)+(HCO3-) then the reaction should shift to the left forming more CO2 (which result in hyperventilation ) and less HCO3
    for the hyperkalemia part i totally agree with step enhancer.

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