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Why Does Ketoacidosis Cause Vomiting

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Physiology Of Vomiting

"At least after death you're not nauseous." Woody Allen in Sleeper Vomiting is the forceful expulsion of contents of the stomach and often, the proximal small intestine. It is a manifestation of a large number of conditions, many of which are not primary disorders of the gastrointestinal tract. Regardless of cause, vomiting can have serious consequences, including acid-base derangments, volume and electrolyte depletion, malnutrition and aspiration pneumonia. The Act of Vomiting Vomiting is usually experienced as the finale in a series of three events, which everyone reading this has experienced: Nausea is an unpleasant and difficult to describe psychic experience in humans and probably animals. Physiologically, nausea is typically associated with decreased gastric motility and increased tone in the small intestine. Additionally, there is often reverse peristalsis in the proximal small intestine. Retching ("dry heaves") refers to spasmodic respiratory movements conducted with a closed glottis. While this is occurring, the antrum of the stomach contracts and the fundus and cardia relax. Studies with cats have shown that during retching there is repeated herniation of the abdominal es Continue reading >>

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  1. AMZMD

    The human body is in a constant process of maintaining equilibrium. The byproducts of burning fat for energy (ketones) are deposited in the blood for excretion. As the ketones build up in your system, the pH of your blood drops and you become acidotic. As stated above, your body is trying to maintain equilibrium, so it will do certain things to eliminate as much acid from your system as possible, as quickly as possible. One way is to vomit, which dumps huge amounts of H+ instantly. Other reactions are increased respirations to eliminate CO2, as well as dumping the ketones and H+ out through your urine.
    As a side note, the dumping of H+ through urine causes the retention of potassium and you become hyperkalemic (aka "too-much-potassium-emia"). This inhibits myocardial function and can put you into cardiac arrest. This is why extreme no-carb diets are a very bad thing!
    Hope that helps!

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Question: From Cleveland, Ohio, USA: My son's pump malfunctioned last night in the middle of the night and we don't know exactly how long he was not receiving his insulin. He woke up with a "high" glucose and an episode of vomiting. Being on vacation, we did not have ketostix, but the smell of his breath gave evidence to his high ketones. We immediately bolused him via injection and changed his site. We continued frequent blood sugar checks and started pushing fluids. The vomiting continued for two more episodes and his blood sugar finally started coming down so he stopped vomiting and was able to keep fluids down. We were with extended family, who, of course, had questions. One of the questions was,"Why do high blood sugars and ketones cause vomiting?" I realized that even after dealing with my son's illness for eight years and working as an ICU nurse and treating DKA in patients, I don't know the pathophysiology of this process! My guess is it has something to do with the metabolic changes and the changeover to an acid state in the blood. I really don't know and I can't find the answer anywhere on the net. I appreciate any information and please be as technical as you'd like. Ans Continue reading >>

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  1. AMZMD

    The human body is in a constant process of maintaining equilibrium. The byproducts of burning fat for energy (ketones) are deposited in the blood for excretion. As the ketones build up in your system, the pH of your blood drops and you become acidotic. As stated above, your body is trying to maintain equilibrium, so it will do certain things to eliminate as much acid from your system as possible, as quickly as possible. One way is to vomit, which dumps huge amounts of H+ instantly. Other reactions are increased respirations to eliminate CO2, as well as dumping the ketones and H+ out through your urine.
    As a side note, the dumping of H+ through urine causes the retention of potassium and you become hyperkalemic (aka "too-much-potassium-emia"). This inhibits myocardial function and can put you into cardiac arrest. This is why extreme no-carb diets are a very bad thing!
    Hope that helps!

  2. -> Continue reading
read more
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What is DIABETIC KETOACIDOSIS? What does DIABETIC KETOACIDOSIS mean? DIABETIC KETOACIDOSIS meaning - DIABETIC KETOACIDOSIS definition - DIABETIC KETOACIDOSIS explanation. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. SUBSCRIBE to our Google Earth flights channel - https://www.youtube.com/channel/UC6Uu... Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of diabetes mellitus. Signs and symptoms may include vomiting, abdominal pain, deep gasping breathing, increased urination, weakness, confusion, and occasionally loss of consciousness. A person's breath may develop a specific smell. Onset of symptoms is usually rapid. In some cases people may not realize they previously had diabetes. DKA happens most often in those with type 1 diabetes, but can also occur in those with other types of diabetes under certain circumstances. Triggers may include infection, not taking insulin correctly, stroke, and certain medications such as steroids. DKA results from a shortage of insulin; in response the body switches to burning fatty acids which produces acidic ketone bodies. DKA is typically diagnosed when testing finds high b

Understanding The Presentation Of Diabetic Ketoacidosis

Hypoglycemia, diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar nonketotic syndrome (HHNS) must be considered while forming a differential diagnosis when assessing and managing a patient with an altered mental status. This is especially true if the patient has a history of diabetes mellitus (DM). However, be aware that the onset of DKA or HHNS may be the first sign of DM in a patient with no known history. Thus, it is imperative to obtain a blood glucose reading on any patient with an altered mental status, especially if the patient appears to be dehydrated, regardless of a positive or negative history of DM. In addition to the blood glucose reading, the history — particularly onset — and physical assessment findings will contribute to the formulation of a differential diagnosis and the appropriate emergency management of the patient. Pathophysiology of DKA The patient experiencing DKA presents significantly different from one who is hypoglycemic. This is due to the variation in the pathology of the condition. Like hypoglycemia, by understanding the basic pathophysiology of DKA, there is no need to memorize signs and symptoms in order to recognize and differentiate bet Continue reading >>

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Popular Questions

  1. AMZMD

    The human body is in a constant process of maintaining equilibrium. The byproducts of burning fat for energy (ketones) are deposited in the blood for excretion. As the ketones build up in your system, the pH of your blood drops and you become acidotic. As stated above, your body is trying to maintain equilibrium, so it will do certain things to eliminate as much acid from your system as possible, as quickly as possible. One way is to vomit, which dumps huge amounts of H+ instantly. Other reactions are increased respirations to eliminate CO2, as well as dumping the ketones and H+ out through your urine.
    As a side note, the dumping of H+ through urine causes the retention of potassium and you become hyperkalemic (aka "too-much-potassium-emia"). This inhibits myocardial function and can put you into cardiac arrest. This is why extreme no-carb diets are a very bad thing!
    Hope that helps!

  2. -> Continue reading
read more

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