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Why Does Hyperkalemia Cause Metabolic Acidosis?

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What is MEDICINAL CHEMISTRY? What does MEDICINAL CHEMISTRY mean? MEDICINAL CHEMISTRY meaning. Source: Wikipedia.org article, adapted under https://creativecommons.org/licenses/... license. Medicinal chemistry and pharmaceutical chemistry are disciplines at the intersection of chemistry, especially synthetic organic chemistry, and pharmacology and various other biological specialties, where they are involved with design, chemical synthesis and development for market of pharmaceutical agents, or bio-active molecules (drugs). Compounds used as medicines are most often organic compounds, which are often divided into the broad classes of small organic molecules (e.g., atorvastatin, fluticasone, clopidogrel) and "biologics" (infliximab, erythropoietin, insulin glargine), the latter of which are most often medicinal preparations of proteins (natural and recombinant antibodies, hormones, etc.). Inorganic and organometallic compounds are also useful as drugs (e.g., lithium and platinum-based agents such as lithium carbonate and cis-platin as well as gallium). In particular, medicinal chemistry in its most common practice focusing on small organic moleculesencompasses synthetic organic chemi

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35 years old male presented with dyspnea (history of arthritis), ABGs showed pH 7.2, CO2 23, HCO3 12, Na 140, Cl 103, K 4.1. The acid base imbalance is: Q2012 B. Metabolic acidosis and respiratory alkalosis C. Metabolic alkalosis and respiratory acidosis D. Metabolic acidosis and respiratory acidosis B* Metabolic acidosis and respiratory alkalosis ABGs showed pH 7.2, PCO2 23, HCO3 16, PO2 85. The acid base imbalance is: Q2012 A. Metabolic alkalosis and respiratory acidosis B. Metabolic acidosis and respiratory alkalosis C. Metabolic alkalosis and respiratory alkalosis E. Metabolic acidosis and respiratory acidosis B* Metabolic acidosis and respiratory alkalosis In a patient with metabolic acidosis, Serum bicarbonate 10, Sodium 130, Calcium 110, Blood glucose 79, Urea 20, the anion gap in this patient is: One of the following causes metabolic alkalosis: A 45 years old patient with severe nephritic syndrome is admitted with nausea, fever and vomiting. BP is 90/50 mmHg, HR 110/m, RR 20/m, pH 7.05, PaCO2 32mmHg, Na 132mmol/L, K 4.0mmol/L, Cl 103mmol/L, HCO3 17mmol/L, albumin 1.5g/dl, BUN 20mg/dl, Creatinine 1.4mg/dl. One of the following acid base disorders is present: C. Non anion ga Continue reading >>

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  1. Nathaniel Teng

    Metabolic Acidosis

    Hyperkalemia

    Medicine and Healthcare



    What are hyperkalemia and metabolic acidosis?




    1 Answer







    Hyperkalemia = high potassium levels in the blood. Commonly due to renal failure- kidneys not able to get rid of potassium so it builds up in your body. Hyperkalemia can be fatal because it causes heart arrhythmias including ventricular fibrillation.

    Metabolic acidosis is also a result of renal failure and is due to the kidneys not being able to excrete enough acid. Normally the pH of your blood is 7.35–7.45, so anything below 7.35 is considered ‘acidosis'. Metabolic in this case simply means caused by the kidneys, as opposed to ‘respiratory' acidosis which is due to airway obstruction and not being able to breathe out enough CO2

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    Why does hyperkalemia cause muscle paralysis?
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Mannitol | Student Doctor Network

SDN members see fewer ads and full resolution images. Join our non-profit community! Why does mannitol induce metabolic acidosis and hyperkalaemia? Potassium follows water around, so a hyperosmotic state tends to become hyperkalemic as well. I'm not sure about the acidosis. - Mannitol draws water from cell --> increased potassium concentration in the cell --> potassium diffuses out of the cell - Water drags potassium along with it while moving out of the cell (solvent drag) [as thehundredthone mentioned] - Mannitol inhibits reabsorption of water and electrolytes in the renal tubules (particularly effective in the PCT as it is the site for maximum reabsorption) --> decreased bicarbonate reabsorption --> bicarbonate leaking --> metabolic acidosis (There may be some better explanations...) The Stewart model of acid-base physiology is not commonly taught in medical school, but came up often in my residency training. It is very useful for predicting and explaining changes in acid-base status in this sort of scenario which is difficult to conceptualize by other approaches. Explaining the entire model is beyond this post, but there's a lot to read online. In this situation, mannitol-indu Continue reading >>

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  1. Nathaniel Teng

    Metabolic Acidosis

    Hyperkalemia

    Medicine and Healthcare



    What are hyperkalemia and metabolic acidosis?




    1 Answer







    Hyperkalemia = high potassium levels in the blood. Commonly due to renal failure- kidneys not able to get rid of potassium so it builds up in your body. Hyperkalemia can be fatal because it causes heart arrhythmias including ventricular fibrillation.

    Metabolic acidosis is also a result of renal failure and is due to the kidneys not being able to excrete enough acid. Normally the pH of your blood is 7.35–7.45, so anything below 7.35 is considered ‘acidosis'. Metabolic in this case simply means caused by the kidneys, as opposed to ‘respiratory' acidosis which is due to airway obstruction and not being able to breathe out enough CO2

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    Related Questions




    How can diarrhea cause metabolic acidosis?


    How does iron poisoning cause metabolic acidosis? How is it treated?


    What are some symptoms of acidosis and hyperkalemia?


    Does metabolic alkalosis help with respiratory acidosis?


    Does hypokalemia cause acidosis or alkalosis? Why?


    How is hyperkalemia related to bradycardia?


    What is uraemic acidosis?


    What causes respiratory acidosis and alkalosis?


    How metabolic acidosis leads to CNS toxicity?


    Why does hyperkalemia cause muscle paralysis?


    How do people develop acidosis and hyperkalemia?


    How are acidosis and hyperkalemia treated?


    Why does metabolic acidosis occur?


    Does Metformin cause metabolic alkalosis or metabolic acidosis?


    How does metabolic acidosis cause abdominal pain?
    Ask New Question






    Related Questions



    How can diarrhea cause metabolic acidosis?


    How does iron poisoning cause metabolic acidosis? How is it treated?


    What are some symptoms of acidosis and hyperkalemia?


    Does metabolic alkalosis help with respiratory acidosis?


    Does hypokalemia cause acidosis or alkalosis? Why?


    How is hyperkalemia related to bradycardia?


    What is uraemic acidosis?


    What causes respiratory acidosis and alkalosis?


    How metabolic acidosis leads to CNS toxicity?


    Why does hyperkalemia cause muscle paralysis?
    Ask New Question

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PHYSIOLOGY Normal potassium level is anywhere between 3.5 to 5.0meq per liter. Any amount above this is considered hyperkalemia and any amount below this is considired hypokalemia. Potassium levels are maintained by the sodium-potassium ATPase pump that maintains more potassium inside the cell rather than outside. The resting membrane potential of excitatory cells is most important such as the muscle and neurons. When you eat a banana the food goes into the intestine and eventually goes into the blood. Potassium is absorbed with glucose and so insulin helps lower glucose levels, but also maintains low levels of potassium to prevent hyperkalemia. The muscle has beta 2 receptors and during exercise the muscle release potassium. However, the beta 2 receptors also actiave sodium potassium ATPase channels also helping prevent hyperkalemia during periods of exercise. The potassium also makes it way to the adrenal gland and causes release of aldosterone which acts on the principal cells in the distal convulated tubules. On these cells more potassium is released into the urine preventing hyperkalemia by increase sodium channels and increase sodium potassium ATPase channels. ETIOLOGY PF HYP

Acidosis And Hyperkalemia - Usmle Forums

Normally, we associate acidosis and hyperkalemia because when there is an excess of H+ in the blood, K+ leaves the cell in exchange for H+, thus hyperkalemia. In RTA I and II, we have to look at the renal tubules. In RTA I, H+ cannot be secreted properly. This is in part due to dysfunction of the H+/K+ exchanger in the distal tubule. Normally, H+ is secreted and K+ is absorbed. In RTA I, this is defective and thus K+ cannot be reabsorbed by this exchanger and is lost in urine --> Hypokalemia In RTA II, there is defective HCO3- reabsorption. Since there is more HCO3-, more Na+ will follow because of opposite charge. This means that less Na+ is reabsorbed in the PCT and more is delivered to the DCT. In the distal tubule, the increased Na+ leads to increased exchange of Na+ and K+, with Na+ being reabsorbed and K+ being secreted. --> Hypokalemia (this mechanism is not very well established so if it doesn't make too much sense then I would just memorize the association) Aldosterone increases H+ and K+ excretion in exchange for Na+ so increased aldosterone would lead to hypokalemia as well, but this is not really the mechanism in RTA I and II because the RAA system is not really involv Continue reading >>

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Popular Questions

  1. Nathaniel Teng

    Metabolic Acidosis

    Hyperkalemia

    Medicine and Healthcare



    What are hyperkalemia and metabolic acidosis?




    1 Answer







    Hyperkalemia = high potassium levels in the blood. Commonly due to renal failure- kidneys not able to get rid of potassium so it builds up in your body. Hyperkalemia can be fatal because it causes heart arrhythmias including ventricular fibrillation.

    Metabolic acidosis is also a result of renal failure and is due to the kidneys not being able to excrete enough acid. Normally the pH of your blood is 7.35–7.45, so anything below 7.35 is considered ‘acidosis'. Metabolic in this case simply means caused by the kidneys, as opposed to ‘respiratory' acidosis which is due to airway obstruction and not being able to breathe out enough CO2

    117 Views








    Promoted by PlateJoy


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    Learn More at platejoy.com/health








    Related Questions




    How can diarrhea cause metabolic acidosis?


    How does iron poisoning cause metabolic acidosis? How is it treated?


    What are some symptoms of acidosis and hyperkalemia?


    Does metabolic alkalosis help with respiratory acidosis?


    Does hypokalemia cause acidosis or alkalosis? Why?


    How is hyperkalemia related to bradycardia?


    What is uraemic acidosis?


    What causes respiratory acidosis and alkalosis?


    How metabolic acidosis leads to CNS toxicity?


    Why does hyperkalemia cause muscle paralysis?


    How do people develop acidosis and hyperkalemia?


    How are acidosis and hyperkalemia treated?


    Why does metabolic acidosis occur?


    Does Metformin cause metabolic alkalosis or metabolic acidosis?


    How does metabolic acidosis cause abdominal pain?
    Ask New Question






    Related Questions



    How can diarrhea cause metabolic acidosis?


    How does iron poisoning cause metabolic acidosis? How is it treated?


    What are some symptoms of acidosis and hyperkalemia?


    Does metabolic alkalosis help with respiratory acidosis?


    Does hypokalemia cause acidosis or alkalosis? Why?


    How is hyperkalemia related to bradycardia?


    What is uraemic acidosis?


    What causes respiratory acidosis and alkalosis?


    How metabolic acidosis leads to CNS toxicity?


    Why does hyperkalemia cause muscle paralysis?
    Ask New Question

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