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Why Does Dka Cause Weight Loss

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Hyperosmolar Hyperglycemic State

Acute hyperglycemia, or high blood glucose, may be either the initial presentation of diabetes mellitus or a complication during the course of a known disease. Inadequate insulin replacement (e.g., noncompliance with treatment) or increased insulin demand (e.g., during times of acute illness, surgery, or stress) may lead to acute hyperglycemia. There are two distinct forms: diabetic ketoacidosis (DKA), typically seen in type 1 diabetes, and hyperosmolar hyperglycemic state (HHS), occurring primarily in type 2 diabetes. In type 1 diabetes, no insulin is available to suppress fat breakdown, and the ketones resulting from subsequent ketogenesis manifest as DKA. This is in contrast to type 2 diabetes, in which patients can still secrete small amounts of insulin to suppress DKA, instead resulting in a hyperglycemic state predominated simply by glucose. The clinical presentation of both DKA and HHS is one of polyuria, polydipsia, nausea and vomiting, volume depletion (e.g., dry oral mucosa, decreased skin turgor), and eventually mental status changes and coma. In patients with altered mental status, fingerstick glucose should always be checked in order to exclude serum glucose abnormalit Continue reading >>

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Popular Questions

  1. Kellye P

    My little poodle has been diabetic for 4 years. His glucose levels are good. I have had every imaginable test run on him to find out why he can’t gain weight. Everything checks out perfectly except one time his electrolytes were off. I now put an electrolyte powder in his water. He was 10 lbs when diagnosed and is now 6 pounds. Every bone in his body sticks out. I take him to a Traditional Chinese Medicine vet, an acupunture specialist, and his regular vet. He is on Vetsulin and thyroid. I give him Caniotic probiotics, coconut oil and digestive enzymes. I have gone raw, dehydrated, bought recipes at Balance It, bought recipes from a California company that makes food based on their vet’s advice, tried Sojo’s and other “add meat” foods, dry food, canned food, etc. I have tried everything. High fat foods make him throw up. It is breaking my heart that we are heading back into winter and he’s skin and bones. Yes, he stays inside and wears shirts or sweaters all year, but he is way too skinny.

  2. USA

    Hi Kellye P,
    I am so sorry to hear about your little guy.
    When you say his glucose levels are good can you tell me how often he is tested and what his numbers are please? Has he had a Hemoglobin A1c Test or a Fructosamine test, both of which will show your dog’s average blood sugar over a couple of weeks or months? High blood sugars could interfere with glucose metabolism and cause weight loss.
    He is also on thyroid meds and a high thyroid level could also cause weight loss. Does he take thyroid medicine once or twice a day? He should be taking his meds twice a day not once. His thyroxine (T4) levels should be tested about 4 hours after giving him his thyroid medicine and should be high normal to about 25% over normal.
    Does he just stop eating after he eats a certain amount of food? Would it be possible for you to feed him 25% more than you are feeding him now?
    Please let me know these things so we can all try to figure out how to help your little guy gain some weight.

  3. Kellye P

    Thanks for the response. He gets the Fructosamine test every six months. He is always in the proper range. He is due to get tested again in October so I will have new numbers, but nothing has changed. He does not drink a lot of water or have any other symptoms of high glucose.
    Last year I had the complete thyroid panel done – every single test. I thought maybe he was too high. He takes .1 mg of thyroxine twice a day. I was hoping that was the problem but all the tests came back normal. My vet is very particular with the timing so I’m sure she had me in the office 4 hours after he took his pill.
    He is so tiny and cannot eat much at one time. I feed him exactly twelve hours apart but give him a little bit of food around noon and he gets a small snack at night. If he eats more than his usual amount, he throws up. His tiny stomach can’t hold more than half a cup.
    I exercise him 30 minutes a day. He’s blind but can fetch in the house and will trot behind me on our very long driveway. The TCM vet does chiropractic adjustments and says his muscles are in pretty good shape. We walk uphill and he goes up our stairs.
    A specialist in this area also treats him and consults with my vet. He suggested that we stop insulin for three days to reset him and then start up again. During the days he was not getting insulin, his glucose levels were right around 250. However, his urine test showed ketones. The specialist said that did not make sense. My vet said she probably would have taken him off insulin if he stayed at 250 without it. The ketones messed up that plan, though. Nobody has any explanation as to why he had ketones. I think that is the key to the weight problem but I have no idea what it means.
    I have taken him to a vet school and many other specialists. He is a medical mystery. The good news is that he is quite content and if he knew how much time I spent trying to figure out why he won’t gain weight, he’d probably think I was crazy!

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