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Why Does Chloride Cause Acidosis?

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Whether due to bicarbonate loss or volume repletion with normal saline, the primary problems is in hyperchloremic metabolic acidosis hcl ammonium chloride loading, reabsorption proximal tubule reduced, part, because of hyperchloraemic acidosis, anion gap (in most cases). Administration of ns will decrease the plasma sid causing an acidosis this patient also had a normal anion gap hyperchloremic metabolic (hcma). Googleusercontent search. Normal anion gap (hyperchloremic) acidosis semantic scholar. Hyperchloremic metabolic acidosis is it clinically relevant? (pdf hyperchloremic in diabetes mellitus. Hyperchloremic acidosis wikipedia. Treatment of acute non anion gap metabolic acidosis ncbi nih. Aug 4, 2016 a normal ag acidosis is characterized by lowered bicarbonate concentration, which counterbalanced an equivalent increase in plasma chloride concentration. Acid base physiology 8. Hyperchloraemic metabolic acidosisdepartment of medicine. Mechanism of hyperchloremic metabolic acidosis. Hyperchloremic acidosis background, etiology, patient education emedicine. Respiratory acidosis alkalosis as with the hyperchloremic may result from chloride replacing lost bicarbonate. Although it ca

Hyperchloremic Acidosis

Normal human physiological pH is 7.35 to 7.45. A decrease in pH below this range is acidosis, an increase in this range is alkalosis. Hyperchloremic acidosis is a metabolic disease state disease state where acidosis (pH less than 7.35) with an ionic chloride increase develops.Understanding the physiological pH buffering process is important. The primary pH buffer system in the human body is the HCO3 (Bicarbonate)/CO2 (carbon dioxide) chemical equilibrium system. Where: HCO3 functions as an alkalotic substance.CO2 functions as an acidic substance. Therefore, increases in HCO3 or decreases in CO2 will make blood more alkalotic. The opposite is also true where decreases in HCO3 or an increase in CO2 will make blood more acidic. CO2 levels are physiologically regulated by the pulmonary system through respiration, whereas the HCO3 levels are regulated through the renal system with reabsorption rates. Therefore, hyperchloremic metabolic acidosis is a decrease in HCO3 levels in the blood. Anytime a metabolic acidosis is suspected, it is extremely useful to calculate the anion gap. This is defined as: Where Nais plasma sodium concentration, HCO3 is plasma bicarbonate concentration, and Cl Continue reading >>

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  1. silver lady

    As the above asks.
    Replies greatly appreciated XO XO R.

  2. silver lady

    any one???

  3. silver lady

    bump

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Block 2, Week 8, Faculty Objective 6

Physiological Effects Of Hyperchloraemia And Acidosis

Physiological effects of hyperchloraemia and acidosis Chelsea and Westminster NHS Foundation Trust Chelsea and Westminster NHS Foundation Trust BJA: British Journal of Anaesthesia, Volume 101, Issue 2, 1 August 2008, Pages 141150, J. M. Handy, N. Soni; Physiological effects of hyperchloraemia and acidosis, BJA: British Journal of Anaesthesia, Volume 101, Issue 2, 1 August 2008, Pages 141150, The advent of balanced solutions for i.v. fluid resuscitation and replacement is imminent and will affect any specialty involved in fluid management. Part of the background to their introduction has focused on the non-physiological nature of normal saline solution and the developing science about the potential problems of hyperchloraemic acidosis. This review assesses the physiological significance of hyperchloraemic acidosis and of acidosis in general. It aims to differentiate the effects of the causes of acidosis from the physiological consequences of acidosis. It is intended to provide an assessment of the importance of hyperchloraemic acidosis and thereby the likely benefits of balanced solutions. Hyperchloraemic acidosis is increasingly recognized as a clinical entity, a new enemy within, Continue reading >>

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  1. spage_rn

    I have smelled sinus infections like that, but I would definitely keep the appt with the doctor!
    .
    Quote from spage_rn
    Nurses...I am so glad I found this web site (thanks Jeeves!). Anyway, my husband's breath smells like moth balls. Yes, it is disgusting. I am making him an appt at the internist tomorrow. This has been going on since Thursday...poor guy has brushed, flossed, scrubbed and used listerine like crazy. He feels fine.
    I guess I am asking if you all can think of some reason for this!! I have looked and looked on line and in the Merck Manual. All I find is acetone smelling breath for ketosis. And his breath smells like an old man...reminds me of my father in law (66, had prostate cancer 5 years ago). Help!! My husband has no s/sx of diabetes. I have even done finger sticks...always less than 110.
    He had this happen about a year ago but we can't remember what or when it went away.
    thanks for any help or insight.
    :kiss

  2. CDN_NPtobe

    Any problems with urination? Sometimes kidney failure will cause people to be malodorous because its a way for the body to try and rid itself of toxins. He also may have a pharygeal pouch or something that is filling with food that could cause the odor.
    Just ideas--I would agree that he should keep his appointment. Let us know how he makes out...

  3. LydiaGreen

    There are many possibilities so the appointment should definitely be kept. Could be a sinus infection. Does he have any trouble sleeping? Excessive snoring, periods where he stops breathing? My daughter has enlarged adenoids (possible T&A surgery this month) and it doesn't matter how often she brushes, flosses, gargles - she still has bad breath (although, she isn't aware of it - we've never told her. She's seven and the poor kid has more than enough to worry about with the lack of sleep.)

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The varied secretagogues such as vasoactive intestinal peptide (vip), which is associated with neoplasms of the pancreas or sympathetic chain (chapter 201), cause large losses hco 3 in stool, a resulting hypokalemic, hyperchloremic metabolic acidosis. We report two cases of hyperchloremic metabolic acidosis in children posted for colorectal surgery following tgi with summary'these words have been the doctrine medicine since its inception. Also known as non anion gap metabolic acidosis normal albumin corrected strong ion related conditions 'dilutional' or 'infusion related' post diabetic ketoacidosis renal tubular (rta) 29 jun 2006 two thirds of patients in the isotonic saline group but none balanced fluid developed hyperchloremic [3]. Respiratory acidosis alkalosis as with the henderson hasselbalch equation. Treatment of these disorders requires reversing the underlying disease process, with bicarbonate offering little if any benefit. Hyperchloraemic metabolic acidosis. Treatment of acute non anion gap metabolic acidosis. The colloid crystalloid debate continues to evolve this method of evaluating acid base disorders was developed help determine the mechanism disorder rather than s

Hyperchloremic Acidosis

Normal albumin-corrected anion gap acidosis Hyperchloremic acidosis is a common acid-base disturbance in critical illness, often mild (standard base excess >-10 mEq/L). Definitions of hyperchloremic acidosis vary. The best are not based on chloride concentrations, but on the presence of metabolic acidosis plus the absence of significant concentrations of lactate or other unmeasured anions. 2. standard base excess less than -3 mEq/L or bicarbonate less than 22 mmol/L, 3. Albumin corrected anion gap normal (5-15 mEq/L). A normal strong ion gap is an alternative indicator of the absence of unmeasured anions, although rarely used clinically and offering little advantage over the albumin corrected anion gap. The degree of respiratory compensation is relevant. It is appropriate if PaCO2 approximates the two numbers after arterial pH decimal point (e.g. pH=7.25, PaCO2=25 mm Hg; this rule applies to any primary metabolic acidosis down to a pH of 7.1). Acidosis is severe if standard base excess is less than -10 mEq/L, or pH is less than 7.3, or bicarbonate is less than 15 mmol/L. Common causes in critical illness are large volume saline administration, large volume colloid infusions (e.g. Continue reading >>

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  1. Bobhes

    What is the best time of the day to check blood ketone levels? I've heard that upon rising is a bad time because the body produces glucose overnight while you sleep. I've heard others say mid afternoon and still others at night at the end of the day.

    Please unconfuse this confused keto novice. Thanks in advance!

  2. Shortstuff

    I've been testing three times a day, just out of curiosity.
    Can't keep doing it as the test strips are so expensive, but interesting to gauge things properly.

  3. MaryAnn

    Bobhes:


    I've heard that upon rising is a bad time because the body produces glucose overnight while you sleep.
    I've heard this too. But I'm doing an N=1 experiment and my blood ketone readings are higher in the AM (generally).

    Not fasting *approx 5 hrs after eating Ketones: 3.9

    Not fasting (mid afternoon) Ketones: 1.4

    Not Fasting (approx 5 hrs after eating) Ketones 2.0

    Not Fasting (approx 3.5 hrs after eating) Ketones 1.6

    Fasting Ketones 3.3

    Fasting Ketones 2.9

    Fasting but a few hours (3) after ACV Ketones 2.8

    Fasting Ketones 3.6

    Not Fasting 2.2

    Not fasting means in the afternoon and at least after 1 meal. My first reading was the highest and it was in the afternoon. These are all separate day measurements. I haven't done the test in the AM and the PM (only because of cost). Will try that next.

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