Trade Names: generic, Diamox, Diamox Sequels Drug Class: diuretic (carbonic anhydrase inhibitor) The diuretic effect of acetazolamide is due to its action in the kidney on the reversible reaction involving hydration of carbon dioxide and dehydration of carbonic acid. The result is renal loss of bicarbonate (HCO3 ion), which carries out sodium, water, and potassium. Alkalinization of the urine and promotion of diuresis are the end result. Alteration in ammonia metabolism occurs due to increased reabsorption of ammonia by the renal tubules as a result of urinary alkalinization. Carbonic anhydrase inhibitors were the forerunners of modern diuretics. Legend. Mechanism of action of carbonic anhydrase inhibitor diuretics. Bicarbonate absorption by the proximal tubule is dependent on the activity of carbonic anhydrase (CA) which converts bicarbonate (HCO3-) to CO2 and H2O. CO2 rapidly diffuses across the cell membrane of proximal tubule cells where it is rehydrated back to H2CO3 by carbonic anhydrase. H2CO3 dissociates to HCO3- and H+ which are transported out of the cell on the basolateral side by different transporters. Bicarbonate absorption is therefore dependent on the activity of c
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Acetazolamide - Pharmapedia
Acetazolamide, sold under the trade name Diamox, is a carbonic anhydrase inhibitor that is used to treat glaucoma, epileptic seizures, benign intracranial hypertension (pseudotumor cerebri), altitude sickness, cystinuria, and dural ectasia. Acetazolamide is available as a generic drug and is also used as a diuretic. This section may be confusing or unclear to readers. Please help clarify the article; suggestions may be found on the talk page. (June 2009) This drug is a carbonic anhydrase inhibitor. Carbonic anhydrase (CA) catalyzes the forward motion of molecules in the following equation: where CA converts carbon dioxide (CO2) and water (H2O) to carbonic acid (H2CO3), which then dissociates to a hydrogen ion (H+, an acidic proton), and a bicarbonate ion (HCO3-, a basic anion). In some tissues (particularly plants), the equilibrium is such that CA can catalyze the reverse direction of the reaction. Carbonic acid inhibitors, such as acetazolamide, inhibit CA in tissue and fluid, causing less movement of carbonic acid toward CO2 production. In the kidneys, blocking CA leads to bicarbonate wasting in the tubules (alkalizes urine), loss of bicarbonate subsequently leads to a metabolic
Symptoms of hyperchloremia and associated nursing actions. Produced at Broome Community College by Prof. J. Houghtalen and Tera Doty-Blance, Instructional Designer.
How Does Acetazolamide Cause Hyperchloremia?
SDN members see fewer ads and full resolution images. Join our non-profit community! how does acetazolamide cause hyperchloremia? I'm trying to figure out why (mechanism). Acidosis makes sense, and so does hypokalemia. Thanks. I think it's because carbonic anhydrase inhibitors prevent HCO3 reabsorption, so more sodium is being excreted as NaHCO3 instead of NaCl. every non-anion gap acidosis has hyperchloremia. it's inevitable, and unimportant It causes a non-anion gap metabolic acidosis. As the negative bicarb is ridded by the kidney, another anion needs to fill its place in the serum, and this is done by Cl. What makes sense to me, but I could be totally wrong is: Acidosis stimulates the release of aldosterone -> increase in activity of NaCl Cotransporter in early DCT-> Hyperchloremia Pretty sure Aldo isn't involved in the NCC. What the others have said is correct. What makes sense to me, but I could be totally wrong is: Acidosis stimulates the release of aldosterone -> increase in activity of NaCl Cotransporter in early DCT-> Hyperchloremia Lol, sorry to pick on you, but you couldn't be more wrong. I don't think there's one correct statement in there.
Go to: Introduction Metabolic acidosis is defined as an excessive accumulation of non-volatile acid manifested as a primary reduction in serum bicarbonate concentration in the body associated with low plasma pH. Certain conditions may exist with other acid-base disorders such as metabolic alkalosis and respiratory acidosis/alkalosis 1. Humans possess homeostatic mechanisms that maintain acid-base balance ( Figure 1). One utilizes both bicarbonate ...
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What are the 3 major classes of high altitude disease? 1)Acute mountain sickness (10% at 3500m, 75% at 4500) What are the multitude of systemic effects that make acteozolamide effective besides inducing metabolic acidosis (inducing chemoreceptors to respond more to hypoxic stimuli at high altitude? -Improvements in ventilation through, tissue respiratory acidosis -improvements in sleep quality from carotid body CA inhibition What are the two hyp ...
Type 2 Renal Tubular Acidosis and Acetazolamide This form of renal tubular acidosis decreases the strong ion difference by interfering with bicarbonate resorption in the proximal tubule; the mechanism is analogous to the action of acetazolamide. Bicarbonate handling in the proximal tubule Behold, the familiar activity of carbonic anhydrase in the proximal tubule. Carbonic anhydrase converts the filtered bicarbonate into easily resorbed CO2, and ...
INTRODUCTION Metabolic alkalosis is characterized by a primary rise in the plasma bicarbonate concentration, which leads to an increase in arterial pH. Two factors are required for the genesis and then maintenance of metabolic alkalosis: a process that raises the plasma bicarbonate concentration and a process that prevents excretion of the excess bicarbonate in the urine [1,2]. Treatment of metabolic alkalosis should be aimed at reversing these t ...