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Why Do Diabetics Produce High Levels Of Ketone Bodies?

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http://armandoh.org/ Ketone body production from acetyl Coa and its use.

Ketone Body Production And Disposal In Diabetic Ketosis. A Comparison With Fasting Ketosis.

Abstract This work compares the metabolism of total ketone bodies in 13 insulin-deprived, type I diabetic subjects and 26 control subjects fasted for 15 h to 23 days, with the two groups showing a similar range of ketone body levels (1-12 mM). Ketone turnover rate was measured using a primed, constant infusion of either 14C-acetoacetate or 14C-beta-hydroxybutyrate, both tracers yielding comparable results. The major conclusions of this study are the following: the kinetics of ketone bodies are comparable in the two groups within the range of concentrations tested. The hyperketonemia of fasting and diabetes is primarily caused by an increased production of ketone bodies, but the phenomenon is amplified by a progressive limitation in the ability of tissues to remove ketones from blood as the concentration rises. The inverse relationship between the metabolic clearance and the plasma levels of ketones, which underlies this process, represents a general characteristic of ketone body metabolism that applies to both types of ketosis. A maximal metabolic disposal rate of about 2.3 mmol/min/1.73 m2 is attained in both groups at concentrations of 10-12 mM, which correspond to the highest ke Continue reading >>

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Popular Questions

  1. Bellyman

    I am just wondering if there are any signs of ketosis that one can watch for that a person can see without any sort of testing? Are there things that happen physically that give clues?
    I don’t have any means of testing anything. I have a simple bathroom scale. That’s pretty much my only tool.
    I’ve been eating what I think is a pretty strict keto diet for about 4 days shy of one month. I’ve had a day or two when I didn’t exactly feel the greatest but never anything resembling the flu. I’ve had a couple of small oopsies but quite small ones, not within the last week or so, and less than I would have fingers for counting on one hand. I’ve been pretty good. I haven’t done anything extraordinary exercise wise, just a little walking. I’ve lost 19 pounds and feel pretty good. Brain seems pretty clear. No real issues that I can point towards except maybe a few restless nights, but even that isn’t dramatic, and getting used to new bowel habits.
    One thing I have noticed several times in the last week, when I take a shower in the mornings, I kinda notice what I think might be my breath. It’s not quite the same acetone smell I’ve noticed after a hard workout (when I had my elliptical machine). But it’s still a peculiar smell. I’ve wondered if that might be a hint that I may be in ketosis.
    So that got me to wondering whether that or maybe some other subtle things might be little clues of being in ketosis.
    I hope I haven’t plowed right into the content of a previous thread. I didn’t see it if it’s here, though, I’ll be the first to admit, I haven’t read them all.
    Glad to hear what you think if you’d care to share!

    And thanks for being here to talk about something that so many people haven’t a clue about. To most, it’s total deer-in-the-headlights talking about keto.

  2. Just_Todd

    Bellyman:
    And thanks for being here to talk about something that so many people haven’t a clue about. To most, it’s total deer-in-the-headlights talking about keto.

    The people here are the salt of the earth. (See what I did there?) I’m curious to hear responses to your question.

  3. Daisy

    Unless you have a really broken metabolism and need super super low carbs you are in ketosis and have been for a while. It does take a bit longer to really start running on fat as routine - what people call being fat adapted.

    It drove me mad not knowing though and I had to get gadgets!

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This video will show you about some special medical investigations for measure blood glucose level in body. Good knowledge about these tests will definitely help you in prevent further complications. Cholesterol cholesterol sinhala High blood cholesterol sinhala Blood cholesterol sinhala ayurvedic treatments low cholesterol foods sinhala high cholesterol foods sinhala cholesterol test sinhala medical channel diabetes sinhala hypertention high blood pressure sinhala diet obesity sinhala weight loss sinhala sinhala health tips Slnotes Sl Notes FB page - https://web.facebook.com/SLnotes/ Diabetes sinhala blood glucose sinhala Fasting Blood glucose test - FBS Random Blood Glucose test - RBS HbA1c Post prandial glucose test OGTT - oral glucose tolerance test HealthTips Sinhala Medicine Sinhala Educational Videos Sinhala Sl notes Slnotes

Urine Tests For Diabetes: Glucose Levels And Ketones

The human body primarily runs on glucose. When your body is low on glucose, or if you have diabetes and don’t have enough insulin to help your cells absorb the glucose, your body starts breaking down fats for energy. Ketones (chemically known as ketone bodies) are byproducts of the breakdown of fatty acids. The breakdown of fat for fuel and the creation of ketones is a normal process for everyone. In a person without diabetes, insulin, glucagon, and other hormones prevent ketone levels in the blood from getting too high. However, people with diabetes are at risk for ketone buildup in their blood. If left untreated, people with type 1 diabetes are at risk for developing a condition called diabetic ketoacidosis (DKA). While rare, it’s possible for people with type 2 diabetes to experience DKA in certain circumstances as well. If you have diabetes, you need to be especially aware of the symptoms that having too many ketones in your body can cause. These include: If you don’t get treatment, the symptoms can progress to: a fruity breath odor stomach pain trouble breathing You should always seek immediate medical attention if your ketone levels are high. Testing your blood or urine Continue reading >>

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  1. Klangley

    I am a recently diagnosed T2 and new to all this so please excuse a probably stupid question.
    I started a LCHF diet about 6 weeks ago and have lost 7, actually almost 8kg. I am very disciplined. I don't count my carbs but exclusively eat only very low carb foods. I would estimate less than 25g. I also have taken to walking every day, minimum 5 miles occasionally twice that. My average mmol/mol (i measure pre-breakfast, pre-dinner and 2 hrs after dinner) has fallen to 6.2. That is quite a drop from my last (only) HbA1c which was 79 (so in the 12 mmol/mol range). I am obviously pretty pleased with the way things are going and as you can imagine a born-again LCHF practitioner.
    Last week though my weight loss stopped dead. I was a bit worried that I had plateaued or fallen out of Ketosis. I ordered some Ketostix on line to check. In the meantime I was reading some stuff from Dr Fung and thought I would try a 24hr fast just to kick-start my weight loss. I found that easier than I expected. When I checked by weight today it had started losing weight again. Then the Ketostix arrived in the mail. When I checked my urine the measurement was between two colours and 0.4 - 0.8 g/l (or 4 - 8 mmol/L or 40 - 80 mg/dl). So quite far to the right and definitively in Ketosis.
    Problem is I am not entirely sure how to interpret this. I saw a chart on one of the threads which seemed show this level was beyond green and into an amber zone. I say 'seemed to' because it wasn't clear what the units were, but anyway. It is true though the thread was discussing Type 1 not Type 2. My question is this, should I be worried by this reading? Am I overdoing it?

  2. robert72

    The trouble with ketostix is that they are not all that accurate. It can depend on how much water you are drinking/passing. I sometimes get result like yours but when I check my blood ketones using a meter they are usually less.

  3. Klangley

    robert72 said: ↑
    The trouble with ketostix is that they are not all that accurate. It can depend on how much water you are drinking/passing. I sometimes get result like yours but when I check my blood ketones using a meter they are usually less. Thanks
    @robert72 there certainly isn't much granularity for the results. There are only a range of 6 colours on the side of the container.

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READ MORE HERE: https://goo.gl/RBTAiv Beta hydroxybutyrate (BHB) is the first ketone body produced in a fasting state. It is commonly produced by the body during periods without much food (glucose) in order to provide an alternative energy fuel source. Although it is not technically a ketone (owing to the bonding structure), for the purposes of this post it is. Diets that are low in carbohydrates and high in fatty acids can either prompt the body to produce ketone bodies, such as beta hydroxybutyrate, or allow people to consume them exogenously (outside the body) instead. These exogenous ketone supplements have grown in popularity along with the ketogenic diet and media attention from popular icons such as Tim Ferriss and Dave Asprey. Although supplementation of beta hydroxybutyrate has been described as jet fuel and undesirable, modern iterations of exogenous ketones are making it easier for anyone to utilize these ketone bodies for optimal brain performance. There are a host of benefits of beta hydroxybutyrate, but it is primarily known as a fuel source in the absence of glucose. Within 24 72 hours without food, the body no longer uses glucose as the main fuel support system, which is when ketones like beta hydroxybutyrate kick into production. Fasting as long as 382 days (with medical supervision) is possible purely because of ketone production. Evidence suggests that beta hydroxybutyrate can increase the level of brain-derived neurotrophic factor (BDNF) in the hippocampus, which is the main memory center of the brain. This is some of the only published literature about the performance enhancing effects of beta hydroxybutyrate, though there are several self-experiments. Namely, Dr. Peter Attia (popularized by Tim Ferriss podcast and Attias blog) has concluded there are benefits of reduced oxygen consumption by the brain. These statements have been confirmed to some degree by Dr. Dom DAgostino when describing under-water oxygen utilization and ketones, but neither are well-researched. Most of the evidence regarding beta hydroxybutyrate utilizes this exogenous ketone as a way to recovery from memory damage or impairment or as a neuroprotective agent. In one 2004 study of memory-impaired adults, beta hydroxybutyrate successfully aided in improving memory recall. For Alzheimers patients, using beta hydroxybutyrate is particularly helpful as a neuroprotective agent. Many of the long-term and neuroprotective benefits of beta hydroxybutyrate are closely linked to reduced carbohydrate and glucose consumption as well. For those who are consuming both exogenous ketones and eating glucose, the benefits are known. The benefits of beta hydroxybutyrate are not only for people who are currently experiencing nutritional ketosis. Often it is possible for athletes to utilize ketone bodies as a fuel source to limit glycogen depletion.

Diabetes And Ketones

Tweet The presence of high levels of ketones in the bloodstream is a common complication of diabetes, which if left untreated can lead to ketoacidosis. Ketones build up when there is insufficient insulin to help fuel the body’s cells. High levels of ketones are therefore more common in people with type 1 diabetes or people with advanced type 2 diabetes. If you are suffering from high levels of ketones and seeking medical advice, contact your GP or diabetes healthcare team as soon as possible. What are ketones? Ketones are an acid remaining when the body burns its own fat. When the body has insufficient insulin, it cannot get glucose from the blood into the body's cells to use as energy and will instead begin to burn fat. The liver converts fatty acids into ketones which are then released into the bloodstream for use as energy. It is normal to have a low level of ketones as ketones will be produced whenever body fat is burned. In people that are insulin dependent, such as people with type 1 diabetes, however, high levels of ketones in the blood can result from taking too little insulin and this can lead to a particularly dangerous condition known as ketoacidosis. How do I test for Continue reading >>

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Popular Questions

  1. Beastrik

    I find the web telling me to eat oats and fruit and having a protein shake before and after working out. And for obvious reason I can't fit that in. What should I eat based in the keto diet?
    23 240 6'3 Male I don't lift

  2. abdada

    Just eat your macros within a 24 hour period and don't worry about the 1-2% benefits of meal timing or macro cycling until you're deadlifting 500 pounds.
    Post your current:
    age
    weight
    height
    gender
    Big Three Lift PRs
    for more help

  3. ExiledNihilist

    I back this. My former roommate was all about timing, but he was in seriously good shape and at the point where not much else was making improvements for him. Basically told me the same thing.

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